Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats.

Autor: Nahia Ezkurdia, Imma Raurell, Sarai Rodríguez, Antonio González, Rafael Esteban, Joan Genescà, María Martell

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e84374 (2014)

BACKGROUND AND AIM:A neuronal pathway participates in the development of portal hypertension: blockade of afferent sensory nerves in portal vein ligated (PVL) rats simultaneously prevents brain cardiovascular regularory nuclei activation, neuromodula

Externí odkaz: https://doaj.org/article/a0e292b59b854d4099167fbbf5cf110a

Droxidopa, an oral norepinephrine precursor, improves hemodynamic and renal alterations of portal hypertensive rats

Autor: María Martell, Jaime Guardia, Nahia Ezkurdia, Salvador Augustin, Rafael Esteban, Imma Raurell, Joan Genescà, Mar Coll, Sarai Rodríguez, Astrid Brull

Publikováno v: Hepatology. 56:1849-1860

We aimed to evaluate the effects of droxidopa (an oral synthetic precursor of norepinephrine) on the hemodynamic and renal alterations of portal hypertensive rats. Sham, portal vein-ligated (PVL), and 4-week biliary duct-ligated (BDL) rats received a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c1a38b0cd456ac62a2199c36ebf5b8
https://doi.org/10.1002/hep.25845

A Yeast Model of the Neurogenic Ataxia Retinitis Pigmentosa (NARP) T8993G Mutation in the Mitochondrial ATP Synthase-6 Gene

Autor: Jean-Paul di Rago, Stéphane Duvezin-Caubet, Joanna Rytka, Nahia Ezkurdia, Maïlis Bietenhader, Malgorzata Rak, Emmanuel Tetaud

Publikováno v: Journal of Biological Chemistry. 282:34039-34047

NARP (neuropathy, ataxia, and retinitis pigmentosa) and MILS (maternally inherited Leigh syndrome) are mitochondrial disorders associated with point mutations of the mitochondrial DNA (mtDNA) in the gene encoding the Atp6p subunit of the ATP synthase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb664820a0f9c1f9a0b0e187b8ba3bc
https://doi.org/10.1074/jbc.m703053200

Defining the pathogenesis of human mtDNA mutations using a yeast model: The case of T8851C

Autor: Monika Wysocka-Kapcinska, Nadine Camougrand, Marie-France Giraud, Francis Haraux, Bénédicte Salin, Nahia Ezkurdia, Jean Velours, Jean-Paul di Rago, Roza Kucharczyk, Daniel Brèthes

Publikováno v: International Journal of Biochemistry and Cell Biology
International Journal of Biochemistry and Cell Biology, Elsevier, 2013, 45 (1), pp.130-40. ⟨10.1016/j.biocel.2012.07.001⟩

International audience; More and more mutations are found in the mitochondrial DNA of various patients but ascertaining their pathogenesis is often difficult. Due to the conservation of mitochondrial function from yeast to humans, the unique ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e50989a87ea92c57a03b70caddd3fc
https://hal.archives-ouvertes.fr/hal-00735756

A yeast-based assay identifies drugs active against human mitochondrial disorders

Autor: Jean-Paul di Rago, Lars M. Steinmetz, Raeka S. Aiyar, Marie Le Cann, Nahia Ezkurdia, Roza Kucharczyk, Flavie Soubigou, Robert P. St.Onge, Marc Blondel, Bénédicte Salin, Julien Gagneur, Anna Magdalena Kabala, Elodie Couplan

Due to the lack of relevant animal models, development of effective treatments for human mitochondrial diseases has been limited. Here we establish a rapid, yeast-based assay to screen for drugs active against human inherited mitochondrial diseases a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3039f9a24c46fa1bddf43ffcbad7a9
https://hal.archives-ouvertes.fr/hal-00608540