Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Naheed R Mirza"'
GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.
Autor:
Christiaan H Vinkers, Ruud van Oorschot, Elsebet Ø Nielsen, James M Cook, Henrik H Hansen, Lucianne Groenink, Berend Olivier, Naheed R Mirza
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43054 (2012)
Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABA(A)-receptor subtypes.We investigated tolerance to acute anxiolytic, hypo
Externí odkaz:
https://doaj.org/article/5ee477737fd54740b0f36ab1931d5e23
Publikováno v:
Advances in Pharmacological Sciences, Vol 2012 (2012)
Externí odkaz:
https://doaj.org/article/8ca1d796c3e14ec6aad8406dcb7bf27c
Autor:
Philip K. Ahring, A. Garcia de Lucas, Gordon Munro, Janus S. Larsen, J.A. Lopez-Garcia, Naheed R. Mirza, Ivan Rivera-Arconada
Publikováno v:
Biochemical Pharmacology. 93:370-379
GABAA receptor positive allosteric modulators (PAMs) mediate robust analgesia in animal models of pathological pain. Restoration of diminished spinal GABAA-α2 and -α3 subunit-containing receptor function is a principal contributor to this analgesia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3da1b3beb539b8761823ea5b42732f
https://doi.org/10.1016/j.bcp.2014.12.010
https://doi.org/10.1016/j.bcp.2014.12.010
Autor:
Rob Zuiker, Pierandrea Muglia, Joop M. A. van Gerven, Ole Østerberg, Naheed R. Mirza, Xia Chen, Erica S. Klaassen, Marieke de Kam
Publikováno v:
Journal of Psychopharmacology, 30(3), 253-262
NS11821 is a partial GABAA agonist with relatively dominant α2,3 and α5 subtype efficacy but negligible α1 agonism. This first-in-human study was performed in healthy male subjects using a single-dose, parallel, double blind, placebo-controlled, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4832679d6bfce557668f6aaff3ac4b
https://hdl.handle.net/1887/112006
https://hdl.handle.net/1887/112006
Publikováno v:
Journal of Thermal Biology. 37:302-308
Rationale Kv7 channels (KCNQ) are potassium ion channels that are important in controlling neuronal excitability, which have been implicated in psychiatric disorders. Specifically, a role for Kv7 channels in anxiety processes has been proposed. Objec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b386dc3fd24cb6c5c537fbb0aad3ab
https://doi.org/10.1016/j.jtherbio.2011.10.006
https://doi.org/10.1016/j.jtherbio.2011.10.006
Autor:
Javier Sastre Toraño, Elsebet Ø. Nielsen, Gerhardus J. de Jong, Christiaan H. Vinkers, Naheed R. Mirza, Philip K. Ahring, Berend Olivier, Gerdien A.H. Korte-Bouws
Publikováno v:
Psychopharmacology
Background In chronic studies, the classical benzodiazepine chlordiazepoxide (CDP) is often the preferred drug because, unlike other benzodiazepines, it is soluble in water. However, rapid CDP hydrolysis in solution has been described. This would dim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5f05c9b24ee808d797aefd57861314
https://doi.org/10.1007/s00213-009-1752-8
https://doi.org/10.1007/s00213-009-1752-8
Autor:
Naheed R. Mirza, Rene Hummel, Jacob P. R. Jacobsen, Pia Weikop, Elsebet Ø. Nielsen, John Paul Redrobe
Publikováno v:
Psychopharmacology. 199:137-150
Exploring differences between mouse strains in drug effects in models of antidepressant-like activity may provide clues to the neurobiology of antidepressant responses. The objective of this study was to explore whether insensitivity to selective ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19725b0959158bad8e3b49311d04ac0c
https://doi.org/10.1007/s00213-008-1142-7
https://doi.org/10.1007/s00213-008-1142-7
Publikováno v:
Neuropharmacology. 53:609-618
Signs and symptoms of persistent pain are associated with neuronal hyperexcitability within nociceptive pathways. This manifests behaviourally as a decrease in the nociceptive threshold to sensory stimulation, and is closely correlated with altered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26d372da553cf7d723085708230e619
https://doi.org/10.1016/j.neuropharm.2007.07.002
https://doi.org/10.1016/j.neuropharm.2007.07.002
Autor:
Jens D. Mikkelsen, Naheed R. Mirza, Henrik H. Hansen, Pia Weikop, Jørgen Scheel-Krüger, Jesper T. Andreasen
Publikováno v:
European Journal of Pharmacology. 570:77-88
Many central stimulating drugs have a pronounced stimulatory effect on striatal and cortical activity which is associated to enhanced function of mesencephalic dopaminergic neurons. Mesencephalic KCNQ (also termed K(v)7) potassium channels suppress t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74484ef6a0599f327b5ae4a2cd39c22c
https://doi.org/10.1016/j.ejphar.2007.05.029
https://doi.org/10.1016/j.ejphar.2007.05.029
Publikováno v:
Behavioural Pharmacology. 18:191-203
Benzodiazepine receptor anxiolytics show no selectivity between gamma-aminobutyric acid-A receptors containing alpha1, alpha2, alpha3 or alpha5 subunits. Pharmacological studies and data emerging from transgenic mouse models, however, predict that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ce81e327cc4bcba3e80e06e15a17afd
https://doi.org/10.1097/fbp.0b013e32814fcdd4
https://doi.org/10.1097/fbp.0b013e32814fcdd4