Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Nahed N. E. El-Sayed"'
Autor:
Nahed N. E. El-Sayed, Norah M. Almaneai, Abir Ben Bacha, Omar Al-Obeed, Rehan Ahmad, Maha Abdulla, Ahmed M. Alafeefy
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 672-683 (2019)
Some new 3H-quinazolin-4-one derivatives were synthesised and screened for anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities. Compound 15d was more potent in reducing the cell viabilities of HT-29 and SW620 cells li
Externí odkaz:
https://doaj.org/article/2f90c54e91714fb098300001cf1f8843
Autor:
Nahed N. E. El-Sayed, Magdi E. A. Zaki, Sami A. Al-Hussain, Abir Ben Bacha, Malika Berredjem, Vijay H. Masand, Zainab M. Almarhoon, Hanaa S. Omar
Publikováno v:
Pharmaceuticals, Vol 15, Iss 7, p 891 (2022)
Colorectal cancer oncogenesis is linked to dysbiosis, oxidative stress and overexpression of CDK2. The 4H-pyran scaffold is considered an antitumoral, antibacterial and antioxidant lead as well as a CDK2 inhibitor. Herein, certain 4H-pyran derivative
Externí odkaz:
https://doaj.org/article/cb163e7b8fd14868a081f7185de58944
Autor:
Nahed N. E. El-Sayed, Taghreed M. Al-Otaibi, Mona Alonazi, Vijay H. Masand, Assem Barakat, Zainab M. Almarhoon, Abir Ben Bacha
Publikováno v:
Molecules, Vol 26, Iss 11, p 3121 (2021)
The pathogenesis of colorectal cancer is a multifactorial process. Dysbiosis and the overexpression of COX-2 and LDHA are important effectors in the initiation and development of the disease through chromosomal instability, PGE2 biosynthesis, and ind
Externí odkaz:
https://doaj.org/article/63e1396088a4493db14f0b5dbea91f70
Autor:
Magdi E. A. Zaki, Sami A. Al-Hussain, Vijay H. Masand, Siddhartha Akasapu, Sumit O. Bajaj, Nahed N. E. El-Sayed, Arabinda Ghosh, Israa Lewaa
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 357 (2021)
Due to the genetic similarity between SARS-CoV-2 and SARS-CoV, the present work endeavored to derive a balanced Quantitative Structure−Activity Relationship (QSAR) model, molecular docking, and molecular dynamics (MD) simulation studies to identify
Externí odkaz:
https://doaj.org/article/397d20ef4e644a36999074121dcf9e4e
Publikováno v:
Molecules, Vol 17, Iss 7, Pp 8449-8463 (2012)
The reaction of cyanoacetylhydrazine with chloroacetyl chloride gave N'-(2-chloroacetyl)-2-cyanoacetohydrazide. The latter underwent cyclization to afford 1-(5 amino-3-hydroxy-1H-pyrazol-1-yl)-2-chloroethanone, which underwent nucleophilic substituti
Externí odkaz:
https://doaj.org/article/9df279ee14e14418b547959c1351d289
Autor:
Nahed N. E. El-Sayed, Ahmed M. Alafeefy, Mohammed A. Bakht, Vijay H. Masand, Ali Aldalbahi, Nan Chen, Chunhai Fan, Abir Ben Bacha
Publikováno v:
Molecules, Vol 21, Iss 12, p 1664 (2016)
Some novel hydrazone derivatives 6a–o were synthesized from the key intermediate 4-Chloro-N-(2-hydrazinocarbonyl-phenyl)-benzamide 5 and characterized using IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis. The inhibitory potential aga
Externí odkaz:
https://doaj.org/article/e41b33f086ce4877983ae3d565b1f773
Autor:
Nahed N. E. El-Sayed, Norah M. Almaneai, Abir Ben Bacha, Mohamed K. El-Ashrey, Maha I. Al-Zaben, Zainab M. Almarhoon
Publikováno v:
ACS Omega. 7:18443-18458
Colorectal carcinogenesis is a complex process, which is linked to dysregulation of human secretory phospholipases A
Autor:
Mohamed K. El-Ashrey, Seham Alterary, Shimaa Kamal, Hamed A. Derbala, Mona Alonazi, Nahed N. E. El-Sayed, Abir Ben Bacha
Publikováno v:
ACS Omega, Vol 6, Iss 43, Pp 28992-29008 (2021)
Initiation of colorectal carcinogenesis may be induced by chromosomal instability caused by oxidative stress or indirectly by bacterial infections. Moreover, proliferating tumor cells are characterized by reprogrammed glucose metabolism, which is ass
Autor:
Mona S. Alwhibi, Nadine M. S. Moubayed, Ikram Jemel, Nahed N. E. El-Sayed, Abir Ben Bacha, Mona Alonazi
Publikováno v:
Environmental Science and Pollution Research. 28:19890-19900
In this study, the chemical compositions of the ethanolic and aqueous extracts of the leaves of Origanum syriacum and Salvia lanigera were identified based on GC-MS spectrometric analyses. The in vitro anti-inflammatory potential of the different ext
Autor:
Mohammad Y. Alfaifi, Abdullatif Bin Muhsinah, Nahed N. E. El-Sayed, Yahya I. Asiri, Fatima Alatibi, Serag Eldin I. Elbehairi, Yahia N. Mabkhot, Abdulrahman Alsayari
Publikováno v:
Journal of Heterocyclic Chemistry. 57:2911-2922