Heme-thiolate sulfenylation of human cytochrome P450 4A11 functions as a redox switch for catalytic inhibition.

Autor: Albertolle ME; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146., Kim D; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146.; the Department of Biological Sciences, Konkuk University, Seoul 05025, Korea., Nagy LD; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146., Yun CH; the School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Korea., Pozzi A; the Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-6602.; the Veterans Affairs Medical Center, Nashville, Tennessee 37232, and., Savas Ü; the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037., Johnson EF; the Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037., Guengerich FP; From the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, f.guengerich@vanderbilt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Jul 07; Vol. 292 (27), pp. 11230-11242. Date of Electronic Publication: 2017 May 22.

Cyp27c1 Red-Shifts the Spectral Sensitivity of Photoreceptors by Converting Vitamin A1 into A2.

Autor: Enright JM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Toomey MB; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Sato SY; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Temple SE; School of Biological Sciences, University of Bristol, Bristol BS8 1TQ, UK., Allen JR; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Fujiwara R; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Kramlinger VM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Nagy LD; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Johnson KM; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Xiao Y; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., How MJ; School of Biological Sciences, University of Bristol, Bristol BS8 1TQ, UK., Johnson SL; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Roberts NW; School of Biological Sciences, University of Bristol, Bristol BS8 1TQ, UK., Kefalov VJ; Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA., Guengerich FP; Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Corbo JC; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: jcorbo@pathology.wustl.edu.

Publikováno v: Current biology : CB [Curr Biol] 2015 Dec 07; Vol. 25 (23), pp. 3048-57. Date of Electronic Publication: 2015 Nov 05.

Carcinogenesis of urethane: simulation versus experiment.

Autor: Lajovic A; †Laboratory for Molecular Modeling, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia., Nagy LD; ‡Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Guengerich FP; ‡Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Bren U; †Laboratory for Molecular Modeling, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana, Slovenia.; §Laboratory for Physical Chemistry and Chemical Thermodynamics, Faculty of Chemistry and Chemical Technology, University of Maribor, Smetanova 17, SI-2000 Maribor, Slovenia.

Publikováno v: Chemical research in toxicology [Chem Res Toxicol] 2015 Apr 20; Vol. 28 (4), pp. 691-701. Date of Electronic Publication: 2015 Feb 16.

Targeting of splice variants of human cytochrome P450 2C8 (CYP2C8) to mitochondria and their role in arachidonic acid metabolism and respiratory dysfunction.

Autor: Bajpai P; From the Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and., Srinivasan S; From the Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and., Ghosh J; From the Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and., Nagy LD; Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232., Wei S; Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232., Guengerich FP; Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232., Avadhani NG; From the Department of Animal Biology and Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and Narayan@vet.upenn.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2014 Oct 24; Vol. 289 (43), pp. 29614-30. Date of Electronic Publication: 2014 Aug 26.

Kinetics, structure, and mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine bypass by human DNA polymerase η.

Autor: Patra A; From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and., Nagy LD; From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and., Zhang Q; From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and., Su Y; From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and., Müller L; the Laboratory of Food and Nutrition Toxicology, Eidgenössische Technische Hochschule-Zentrum, CH-8092 Zürich, Switzerland., Guengerich FP; From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and., Egli M; From the Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 and martin.egli@vanderbilt.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2014 Jun 13; Vol. 289 (24), pp. 16867-82. Date of Electronic Publication: 2014 Apr 23.