Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Nagraj, Sambrani"'
Autor:
Patricia Deng, Anzer Khan, Dionna Jacobson, Nagraj Sambrani, Leeanne McGurk, Xianghua Li, Aswathy Jayasree, Jan Hejatko, Galit Shohat-Ophir, Mary A. O’Connell, Jin Billy Li, Liam P. Keegan
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human RNA editing enzymes ADAR1 and ADAR2 are required for innate immune functions and neurological functions, respectively. Here, the authors show that Drosophila Adar has both innate immune and brain functions, despite being the homolog of mammalia
Externí odkaz:
https://doaj.org/article/f2300f5bbdf84bf08236658c6672b294
Autor:
Anzer Khan, Simona Paro, Leeanne McGurk, Nagraj Sambrani, Marion C. Hogg, James Brindle, Giuseppa Pennetta, Liam P. Keegan, Mary A. O’Connell
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background In fly brains, the Drosophila Adar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but incr
Externí odkaz:
https://doaj.org/article/323d1e7d06d14570890fd338280d2cc2
Autor:
Ketty Sinigaglia, Nagraj Sambrani, David Michalik, Dragana Vukić, Mary A. O’Connell, Anzer Khan, Liam Keegan, Dagmara M. Wiatrek, Jiří Sedmík
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms
Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in dsRNA. ADAR editing in pre-mRNAs recodes open reading frames and alters splicing, mRNA structure and interactions with miRNAs. Here, we review ADAR gene expression, splice for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd75dbab0da476139ab435ec2f392d5
https://doi.org/10.1016/j.bbagrm.2018.10.011
https://doi.org/10.1016/j.bbagrm.2018.10.011
Autor:
Nagraj Sambrani, Bruno Hudry, Corinne Maurel-Zaffran, Amel Zouaz, Rakesh Mishra, Samir Merabet, Yacine Graba
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003307 (2013)
The emergence following gene duplication of a large repertoire of Hox paralogue proteins underlies the importance taken by Hox proteins in controlling animal body plans in development and evolution. Sequence divergence of paralogous proteins accounts
Externí odkaz:
https://doaj.org/article/6e2da948d78242caadc7c1634041e9b4
Autor:
María Luisa Rivas, Jose Manuel Espinosa-Vázquez, Nagraj Sambrani, Stephen Greig, Samir Merabet, Yacine Graba, James Castelli-Gair Hombría
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003252 (2013)
Extradenticle (Exd) and Homothorax (Hth) function as positive transcriptional cofactors of Hox proteins, helping them to bind specifically their direct targets. The posterior Hox protein Abdominal-B (Abd-B) does not require Exd/Hth to bind DNA; and,
Externí odkaz:
https://doaj.org/article/781a512d46c14bdcb723e4e51316bd17
Autor:
Giuseppa Pennetta, James Brindle, Leeanne McGurk, Nagraj Sambrani, Simona Paro, Mary A. O’Connell, Liam Keegan, Marion C. Hogg, Anzer Khan
Publikováno v:
Khan, A, Paro, S, McGurk, L, Sambrani, N, Hogg, M C, Brindle, J, Pennetta, G, Keegan, L P & O'Connell, M A 2020, ' Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy ', BMC Biology, vol. 18, no. 1, pp. 15 . https://doi.org/10.1186/s12915-020-0747-0
BMC Biology
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
BMC Biology
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
BackgroundIn fly brains, theDrosophilaAdar (adenosine deaminase acting on RNA) enzyme edits hundreds of transcripts to generate edited isoforms of encoded proteins. Nearly all editing events are absent or less efficient in larvae but increase at meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6755339eefd4472c31a666346d790ae
https://www.pure.ed.ac.uk/ws/files/139106310/Khan_Paro_McGurk_27.01.20.pdf
https://www.pure.ed.ac.uk/ws/files/139106310/Khan_Paro_McGurk_27.01.20.pdf
Autor:
Anzer Khan, Paro, Simona, McGurk, Leeanne, Nagraj Sambrani, Hogg, Marion C., Brindle, James, Pennetta, Giuseppa, Keegan, Liam P., O’Connell, Mary A.
Additional file 2: Figure S2. Adar5G1 neurodegeneration at 30 days. Images of 6 micron thick haematoxylin and eosin stained sections through mushroom body calyces (left panels, (63X)) and retinas (right panels, 40X) of 30-day Adar5G1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de105075105d2745537da1fdfaaa54e
Autor:
Anzer Khan, Paro, Simona, McGurk, Leeanne, Nagraj Sambrani, Hogg, Marion C., Brindle, James, Pennetta, Giuseppa, Keegan, Liam P., O’Connell, Mary A.
Additional file 4: Table S1. List of Adar edited transcripts encoding proteins required for autophagy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453bafc3b28fdc15c9d88dd02c8a20ce
Autor:
Anzer Khan, Paro, Simona, McGurk, Leeanne, Nagraj Sambrani, Hogg, Marion C., Brindle, James, Pennetta, Giuseppa, Keegan, Liam P., O’Connell, Mary A.
Additional file 5: Table S2. Primers used for qPCR.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::538b97c8d93d0ec273cd556d6f9c13b7
Autor:
Anzer Khan, Patricia Deng, Xianghua Li, Leeanne McGurk, Liam Keegan, Galit Shohat-Ophir, Jan Hejátko, Mary A. O’Connell, Nagraj Sambrani, Jin Billy Li, Aswathy Jayasree, Dionna Jacobson
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
ADAR RNA editing enzymes are high-affinity dsRNA-binding proteins that deaminate adenosines to inosines in pre-mRNA hairpins and also exert editing-independent effects. We generated a Drosophila AdarE374A mutant strain encoding a catalytically inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410adc673d91b3f3f9286920984b07db