Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nagore de León"'
Autor:
Chen-Chun Pai, Anastasiya Kishkevich, Rachel S. Deegan, Andrea Keszthelyi, Lisa Folkes, Stephen E. Kearsey, Nagore De León, Ignacio Soriano, Robertus Antonius Maria de Bruin, Antony M. Carr, Timothy C. Humphrey
Publikováno v:
Cell Reports, Vol 20, Iss 11, Pp 2693-2705 (2017)
Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the tran
Externí odkaz:
https://doaj.org/article/476647b5f2124f98a48b881cec80a1fc
Autor:
Nagore de León, Mohammad Reza Sharifmoghadam, Marta Hoya, M-Ángeles Curto, Cristina Doncel, M-Henar Valdivieso
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71510 (2013)
The regulation of cell wall synthesis by the clathrin light chain has been addressed. Schizosaccharomyces pombe clc1Δ mutant was inviable in the absence of osmotic stabilization; when grown in sorbitol-supplemented medium clc1Δ cells grew slowly, f
Externí odkaz:
https://doaj.org/article/546763bed0b640e9b8a9e0d0afdc6572
Autor:
Mohammad Reza Sharifmoghadam, M.-Ángeles Curto, Marta Hoya, Nagore de León, Rebeca Martin-Garcia, Cristina Doncel, M.-Henar Valdivieso
Publikováno v:
PLoS ONE, Vol 8, Iss 9 (2013)
Externí odkaz:
https://doaj.org/article/79c19e8a4a364afebfe889067c1eb20d
Autor:
Mohammad Reza Sharifmoghadam, M-Ángeles Curto, Marta Hoya, Nagore de León, Rebeca Martin-Garcia, Cristina Doncel, M-Henar Valdivieso
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42726 (2012)
In yeast, cytokinesis requires coordination between nuclear division, acto-myosin ring contraction, and septum synthesis. We studied the role of the Schizosaccharomyces pombe Bgs1p and Cfh3p proteins during cytokinesis under stress conditions. Cfh3p
Externí odkaz:
https://doaj.org/article/4dffc9ac2add46ba87c42cbc59592d67
Autor:
Claire Palles, Sue Cotterill, Sophia Toumazou, Ignacio Soriano, Stephen E. Kearsey, Ian Tomlinson, Sibyl Bertrand, Enrique Vázquez, Zhihan Bo, Nagore De León, Chen-Chun Pai, Ellen Heitzer, Timothy C. Humphrey
Publikováno v:
Soriano, I, Vazquez, E, De Leon, N, Bertrand, S, Heitzer, E, Toumazou, S, Bo, Z, Palles, C, Pai, C, Humphrey, T C, Tomlinson, I, Cotterill, S, Kearsey, S E & Nitiss, J L (ed.) 2021, ' Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication ', PLoS Genetics, vol. 17, no. 7, pp. e1009526 . https://doi.org/10.1371/journal.pgen.1009526
PLoS Genetics, Vol 17, Iss 7, p e1009526 (2021)
PLoS Genetics
PLoS Genetics, Vol 17, Iss 7, p e1009526 (2021)
PLoS Genetics
Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5736292b02ba16dfe494bf8ee2923a22
https://openaccess.sgul.ac.uk/id/eprint/113593/1/journal.pgen.1009526.pdf
https://openaccess.sgul.ac.uk/id/eprint/113593/1/journal.pgen.1009526.pdf
Autor:
Sibyl Bertrand, Ignacio Soriano, Claire Palles, Sophia Toumazou, Nagore De León, Enrique Vázquez, Chen-Chen Pai, Ian Tomlinson, Sue Cotterill, Stephen E. Kearsey, Timothy C. Humphrey, Ellen Heitzer
Somatic mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associated cancers t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2c0a623070aeb2083a60ebd3012bbdf
https://doi.org/10.1101/2021.04.06.438567
https://doi.org/10.1101/2021.04.06.438567
Autor:
Douglas R. Boettner, Nagore de León, Arun Malhotra, Balaji T. Moorthy, Sandra K. Lemmon, John R. Collette, Verónica A. Segarra, John Creagh
Publikováno v:
Traffic. 17:754-768
Clathrin facilitates vesicle formation during endocytosis and sorting in the trans-Golgi network (TGN)/endosomal system. Unlike in mammals, yeast clathrin function requires both the clathrin heavy (CHC) and clathrin light (CLC) chain, since Chc1 does
Autor:
Sandra Moro, Nagore de León, Cristina Doncel, María Ángeles Curto, María Henar Valdivieso, Marta Hoya, Francisco Yanguas
Publikováno v:
Molecular Microbiology. 100:409-424
In metazoans the AP-2 complex has a well-defined role in clathrin-mediated endocytosis. By contrast, its direct role in endocytosis in unicellular eukaryotes has been questioned. Here, we report co- immunoprecipitation between the fission yeast AP-2
Autor:
Chen Chun Pai, Antony M. Carr, Charalampos Rallis, Timothy C. Humphrey, Nagore De León, Jürg Bähler, Samuel C. Durley, Lisa K. Folkes, Andrea Keszthelyi, Kuo-Feng Hsu, Sarah E. Wilkins, Rachel S. Deegan, Sophia X. Pfister, Stephen E. Kearsey, Christopher J. Schofield
Publikováno v:
Journal of Cell Science
Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is synthetic lethal with mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0115607fec4978c6986b56635e11bc5
Autor:
Cristina Doncel, Francisco Yanguas, Sandra Moro, Nagore de León, Marta Hoya, Cristina Prescianotto-Baschong, María Ángeles Curto, María Henar Valdivieso, Anne Spang
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Despite its biological and medical relevance, traffic from the Golgi to the plasma membrane (PM) is one of the least understood steps of secretion. Exomer is a protein complex that mediates the trafficking of certain cargoes from the trans-Golgi netw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b41e55a009d8335bdfb9b05dbee20d
http://hdl.handle.net/10261/157129
http://hdl.handle.net/10261/157129