Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Nagore Sacristán"'
Autor:
Roberto Fuentes, Leire Aguinagalde, Carlo Pifferi, Adrián Plata, Nagore Sacristán, Donatello Castellana, Juan Anguita, Alberto Fernández-Tejada
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Vaccine adjuvants are key for optimal vaccine efficacy, increasing the immunogenicity of the antigen and potentiating the immune response. Saponin adjuvants such as the carbohydrate-based QS-21 natural product are among the most promising candidates
Externí odkaz:
https://doaj.org/article/018e92f40a3a4cb9a97640b50ff5af60
Autor:
Carlo Pifferi, Leire Aguinagalde, Ane Ruiz-de-Angulo, Nagore Sacristán, Priscila Tonon Baschirotto, Ana Poveda, Jesús Jiménez-Barbero, Juan Anguita, Alberto Fernández-Tejada
Publikováno v:
Chemical Science. 14:3501-3513
The overexpression of aberrantly glycosylated tumor-associated mucin-1 (TA-MUC1) in human cancers makes it a major target for the development of anticancer vaccines derived from synthetic MUC1-(glyco) peptide antigens. However, glycopeptide-based sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90e1253a26a9d866cb63c83f9c0ce595
https://doi.org/10.1039/d2sc05639a
https://doi.org/10.1039/d2sc05639a
Autor:
Claire Tiertant, Alberto Fernández-Tejada, Nathalie Berthet, Ane Ruiz-de-Angulo, Diego Barriales, Juan Anguita, David Goyard, Nagore Sacristán, Olivier Renaudet, Carlo Pifferi
Publikováno v:
Chemical Science
Chemical Science, The Royal Society of Chemistry, 2020, 11 (17), pp.4488-4498. ⟨10.1039/d0sc00544d⟩
Chemical Science, The Royal Society of Chemistry, 2020, 11 (17), pp.4488-4498. ⟨10.1039/d0sc00544d⟩
Tumor associated carbohydrate antigens (TACAs), such as the Tn antigen, have emerged as key targets for the development of synthetic anticancer vaccines. However, the induction of potent and functional immune responses has been challenging and, in mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c4b80a8a179b4e13a4ea587063f356
https://pubmed.ncbi.nlm.nih.gov/34122907
https://pubmed.ncbi.nlm.nih.gov/34122907
Autor:
Juan Anguita, Mattia Ghirardello, Jesús Jiménez-Barbero, Ane Ruiz-de-Angulo, Ana Poveda, Francisco Corzana, Alberto Fernández-Tejada, Diego Barriales, Nagore Sacristán
Publikováno v:
RIUR. Repositorio Institucional de la Universidad de La Rioja
instname
Chemical Communications
instname
Chemical Communications
We report the design, synthesis, immunological evaluation, and conformational analysis of new saponin variants as promising vaccine adjuvants. These studies have provided expedient synthetic access to streamlined adjuvant-active saponins and yielded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa5f91c13e00ab56b4344723a63ef23
https://pubmed.ncbi.nlm.nih.gov/31833496
https://pubmed.ncbi.nlm.nih.gov/31833496
Publikováno v:
Chemical Communications (Cambridge, England)
We report the first synthesis and immunological evaluation of a new glycoconjugate design based on streamlined saponin adjuvants and the Tn carbohydrate antigen. While the novel synthetic constructs induced moderate antibody responses in mice, the ve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e6a200df56088c43b1e917e6799adc