Zobrazeno 1 - 10
of 240
pro vyhledávání: '"Nagomi Kurebayashi"'
Autor:
Atsushi Hori, Haruka Inaba, Takashi Hato, Kimie Tanaka, Shoichi Sato, Mizuho Okamoto, Yuna Horiuchi, Faith Jessica Paran, Yoko Tabe, Shusuke Mori, Corina Rosales, Wado Akamatsu, Takashi Murayama, Nagomi Kurebayashi, Takashi Sakurai, Tomohiko Ai, Takashi Miida
Publikováno v:
PLoS ONE, Vol 19, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/5ffa42cf27004b63ae7f7f53f178f628
Autor:
Takuya Kobayashi, Akihisa Tsutsumi, Nagomi Kurebayashi, Kei Saito, Masami Kodama, Takashi Sakurai, Masahide Kikkawa, Takashi Murayama, Haruo Ogawa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Ryanodine receptor 2 (RyR2) is a Ca2+ release channel essential for cardiac excitation-contraction coupling. Here, the authors use structural and functional analysis to reveal RyR2 gating mechanism and its alterations by pathogenic mutations.
Externí odkaz:
https://doaj.org/article/6fcd432efb114ceaa2b312afe8315510
Autor:
Toshiko Yamazawa, Takuya Kobayashi, Nagomi Kurebayashi, Masato Konishi, Satoru Noguchi, Takayoshi Inoue, Yukiko U. Inoue, Ichizo Nishino, Shuichi Mori, Hiroto Iinuma, Noriaki Manaka, Hiroyuki Kagechika, Arkady Uryash, Jose Adams, Jose R. Lopez, Xiaochen Liu, Christine Diggle, Paul D. Allen, Sho Kakizawa, Keigo Ikeda, Bangzhong Lin, Yui Ikemi, Kazuto Nunomura, Shinsaku Nakagawa, Takashi Sakurai, Takashi Murayama
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mutations in ryanodine receptor 1 (RyR1), a Ca2+ release channel in skeletal muscle, cause malignant hyperthermia (MH) and are involved in heat stroke. Here, the authors show that an oxolinic acid-derivative RyR1 inhibitor effectively prevents and tr
Externí odkaz:
https://doaj.org/article/afd2999f767e49b494c83b5f5e5c1a4b
Autor:
Yui Kuroda, Miki Nonaka, Yuji Kamikubo, Haruo Ogawa, Takashi Murayama, Nagomi Kurebayashi, Hakushun Sakairi, Kanako Miyano, Akane Komatsu, Tetsushi Dodo, Kyoko Nakano-Ito, Keisuke Yamaguchi, Takashi Sakurai, Masako Iseki, Masakazu Hayashida, Yasuhito Uezono
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 141, Iss , Pp 111800- (2021)
Background: The misuse of opioids has led to an epidemic in recent times. The endothelin A receptor (ETAR) has recently attracted attention as a novel therapeutic target to enhance opioid analgesia. We hypothesized that endothelin A receptors may aff
Externí odkaz:
https://doaj.org/article/9d6ee8e217b147f59416574fb884b2ce
Publikováno v:
Bio-Protocol, Vol 11, Iss 15 (2021)
High quantities of purified ryanodine receptor (RyR), a large (2.26 MDa) intracellular homotetrameric membrane protein, can be obtained from heterologous expression in HEK293 cells and used for structure determination by cryo-EM. The advantage of usi
Externí odkaz:
https://doaj.org/article/709a1a14f2b8468fa92bd9dbb82b2aea
Autor:
Miaki Uzu, Miki Nonaka, Kanako Miyano, Hiromi Sato, Nagomi Kurebayashi, Kazuyoshi Yanagihara, Takashi Sakurai, Akihiro Hisaka, Yasuhito Uezono
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 1, Pp 109-112 (2019)
Cancer cachexia is a systemic wasting syndrome characterized by anorexia and loss of body weight. The xanthine oxidase (XO) inhibitor febuxostat is one of the promising candidates for cancer cachexia treatment. However, cachexic symptoms were not all
Externí odkaz:
https://doaj.org/article/328c70525a314051acf5569e9dec61f5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 19, p 10795 (2021)
The ryanodine receptor (RyR) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal and cardiac muscles and plays a key role in excitation–contraction coupling. The activity of the RyR is regulated by the changes in the level of many i
Externí odkaz:
https://doaj.org/article/e20c839a8f334630972bc6a73e765dea
Autor:
Muneaki Hashimoto, Motomichi Doi, Nagomi Kurebayashi, Koji Furukawa, Hiroko Hirawake‐Mogi, Yoshihiro Ohmiya, Takashi Sakurai, Toshihiro Mita, Katsuhiko Mikoshiba, Takeshi Nara
Publikováno v:
FEBS Open Bio, Vol 6, Iss 12, Pp 1178-1185 (2016)
Regulation of intracellular Ca2+ concentration ([Ca2+]i) is vital for eukaryotic organisms. Recently, we identified a Ca2+ channel (TcIP3R) associated with intracellular Ca2+ stores in Trypanosoma cruzi, the parasitic protist that causes Chagas disea
Externí odkaz:
https://doaj.org/article/de8994074b064fe78e98f4c51fd4e836
Autor:
Takashi Murayama, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Junji Suzuki, Kazunori Kanemaru, Katsuji Oguchi, Masamitsu Iino, Takashi Sakurai
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130606 (2015)
The type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal muscle and is mutated in several diseases, including malignant hyperthermia (MH) and central core disease (CCD). Most MH and CCD mutations cause
Externí odkaz:
https://doaj.org/article/88d97002050e480fa564611f31168c05
Autor:
Fuminori Odagiri, Hana Inoue, Masami Sugihara, Takeshi Suzuki, Takashi Murayama, Takao Shioya, Masato Konishi, Yuji Nakazato, Hiroyuki Daida, Takashi Sakurai, Sachio Morimoto, Nagomi Kurebayashi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101838 (2014)
Inherited dilated cardiomyopathy (DCM) is characterized by dilatation and dysfunction of the ventricles, and often results in sudden death or heart failure (HF). Although angiotensin receptor blockers (ARBs) have been used for the treatment of HF, li
Externí odkaz:
https://doaj.org/article/030bf5b5e27b4cc488fa5ef4ff689a0b