Výsledky vyhledávání - "Nagichettiar, Satyamurthy"

Data from Discriminant Analysis of 18F-Fluorothymidine Kinetic Parameters to Predict Survival in Patients with Recurrent High-Grade Glioma

Autor: Sung-Cheng Huang, Michael E. Phelps, Johannes Czernin, Nagichettiar Satyamurthy, Wei Chen, Timothy Cloughesy, Magnus Dahlbom, Christiaan Schiepers, Mirwais Wardak

Purpose: The primary objective of this study was to investigate whether changes in 3′-deoxy-3′-[18F]fluorothymidine (18F-FLT) kinetic parameters, taken early after the start of therapy, could predict overall survival (OS) and progression-free sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad61e623522de3f2f69c84fbf8125314
https://doi.org/10.1158/1078-0432.c.6520359.v1

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Amyloid PET: A Questionable Single Primary Surrogate Efficacy Measure on Alzheimer Immunotherapy Trials

Autor: Poul F. Høilund-Carlsen, Mona-Elisabeth Revheim, Abass Alavi, Nagichettiar Satyamurthy, Jorge R. Barrio

Publikováno v: Journal of Alzheimer's disease : JAD. 90(4)

Using amyloid PET imaging as a single primary surrogate efficacy measure in Alzheimer’s disease immunotherapy trials, as happened when the FDA granted accelerated approval of aducanumab, is unjustified. In vivo evidence indicates that PET quantific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5525d6539e841d8a88d02cc70a952336
https://pubmed.ncbi.nlm.nih.gov/36278356

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Akademický článek

[F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: Effects of aging, in vivo blockade, and anti-Aβ antibody treatment

Autor: Edmond Teng, Vladimir Kepe, Sally A. Frautschy, Jie Liu, Nagichettiar Satyamurthy, Fusheng Yang, Ping-Ping Chen, Graham B. Cole, Mychica R. Jones, Sung-Cheng Huang, Dorothy G. Flood, Stephen P. Trusko, Gary W. Small, Gregory M. Cole, Jorge R. Barrio

Publikováno v: Neurobiology of Disease, Vol 43, Iss 3, Pp 565-575 (2011)

In vivo detection of Alzheimer's disease (AD) neuropathology in living patients using positron emission tomography (PET) in conjunction with high affinity molecular imaging probes for β-amyloid (Aβ) and tau has the potential to assist with early di

Externí odkaz: https://doaj.org/article/eda7aa183a7f4f13948348dcbfe53217

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The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [18F]FDDNP PET

Autor: Nagichettiar Satyamurthy, Sung-Cheng Huang, Graham B. Cole, Koon-Pong Wong, Janez Košmrlj, Jorge R. Barrio, Andrej Petrič, Jie Liu, Gary W. Small

Publikováno v: Molecular Imaging and Biology. 21:25-34

Caution is warranted when in vitro results of biomarkers labeled with tritium were perfunctorily used to criticize in vivo data and conclusions derived with the same tracers labeled with positron emitters and positron emission tomography (PET). This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa70955ff4fd1738d9650a6b152209a0
https://doi.org/10.1007/s11307-018-1210-2

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Efficient synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG)

Autor: Jie Liu, Jorge R. Barrio, Nagichettiar Satyamurthy

Publikováno v: Journal of Fluorine Chemistry. 201:24-42

A new, high radiochemical yield synthesis of [18F]FHBG and [18F]FHPG, the most popular imaging agents currently in use for monitoring gene therapy using positron emission tomography (PET), is reported in this work. Protection of sensitive sites in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2328ae1ecabd1a766f025d4bc566dacc
https://doi.org/10.1016/j.jfluchem.2017.08.007

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Does 2-FDG PET Accurately Reflect Quantitative In Vivo Glucose Utilization?

Autor: Jorge R. Barrio, Claudio Scafoglio, Sung-Cheng Huang, Amy S. Yu, Abass Alavi, Kenneth Krohn, Nagichettiar Satyamurthy

Publikováno v: J Nucl Med
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol 61, iss 6

2-Deoxy-2-(18)F-fluoro-d-glucose (2-FDG) with PET is undeniably useful in the clinic, being able, among other uses, to monitor change over time using the 2-FDG SUV metric. This report suggests some potentially serious caveats for this and related rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646190d7e6988ade6e9a5d77d8921925
https://pubmed.ncbi.nlm.nih.gov/31676728

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Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule

Autor: David R. Powell, Amy S. Yu, Nagichettiar Satyamurthy, Sung-Cheng Huang, Bruce A. Hirayama, Jie Liu, Jorge R. Barrio, Claudio Scafoglio, Vladimir Kepe, Ernest M. Wright, Chiara Ghezzi

Publikováno v: Ghezzi, C; Yu, AS; Hirayama, BA; Kepe, V; Liu, J; Scafoglio, C; et al.(2017). Dapagliflozin Binds Specifically to Sodium-Glucose Cotransporter 2 in the Proximal Renal Tubule. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 28(3), 802-810. doi: 10.1681/ASN.2016050510. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2840m508
Journal of the American Society of Nephrology : JASN, vol 28, iss 3

Kidneys contribute to glucose homeostasis by reabsorbing filtered glucose in the proximal tubules via sodium-glucose cotransporters (SGLTs). Reabsorption is primarily handled by SGLT2, and SGLT2-specific inhibitors, including dapagliflozin, canaglifl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922f7fb359ed8c8d362fb7b979d290ec
https://doi.org/10.1681/asn.2016050510

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FDDNP-PET Tau Brain Protein Binding Patterns in Military Personnel with Suspected Chronic Traumatic Encephalopathy1

Autor: Jacqueline Martinez, Bennet Omalu, Koon-Pong Wong, Stephen T. Chen, Jie Liu, Christopher C. Giza, Julian E. Bailes, Sung-Cheng Huang, Nagichettiar Satyamurthy, David A. Merrill, Prabha Siddarth, Natacha D. Emerson, Jorge R. Barrio, Robert P. Fitzsimmons, Gary W. Small

Publikováno v: Journal of Alzheimer's disease : JAD. 65(1)

Author(s): Chen, Stephen T; Siddarth, Prabha; Merrill, David A; Martinez, Jacqueline; Emerson, Natacha D; Liu, Jie; Wong, Koon-Pong; Satyamurthy, Nagichettiar; Giza, Christopher C; Huang, Sung-Cheng; Fitzsimmons, Robert P; Bailes, Julian; Omalu, Benn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6278a0ceec2a2c1785a2ec46969e27c3
https://pubmed.ncbi.nlm.nih.gov/30040711

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