Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Nagi G Ayad"'
Autor:
Anna M. Jermakowicz, Alison M. Kurimchak, Katherine J. Johnson, Florence Bourgain-Guglielmetti, Simon Kaeppeli, Maurizio Affer, Hari Pradhyumnan, Robert K. Suter, Winston Walters, Maria Cepero, James S. Duncan, Nagi G. Ayad
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Bromodomain and extra-terminal domain (BET) proteins are therapeutic targets in several cancers including the most common malignant adult brain tumor glioblastoma (GBM). Multiple small molecule inhibitors of BET proteins have been utilized i
Externí odkaz:
https://doaj.org/article/4f50f991d1904053be9db08dafc453a4
Autor:
Vasileios Stathias, Chiara Pastori, Tess Z Griffin, Ricardo Komotar, Jennifer Clarke, Ming Zhang, Nagi G Ayad
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115842 (2014)
Patient specific therapy is emerging as an important possibility for many cancer patients. However, to identify such therapies it is essential to determine the genomic and transcriptional alterations present in one tumor relative to control samples.
Externí odkaz:
https://doaj.org/article/9e09bbdd700d4edaa83fa7e8f8e68e73
Publikováno v:
Neural Regeneration Research, Vol 11, Iss 2, Pp 0-0 (2016)
Externí odkaz:
https://doaj.org/article/4438df717b6e469cbb1a477883f2b45d
Autor:
Emma Rowland, Nagi G. Ayad
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 116-117 (2024)
OBJECTIVES/GOALS: Glioblastoma (GBM) is the most malignant brain tumor in adults and remains incurable with an average survival of 15 months after diagnosis. There is great need for treatment options without side effects that are devastating to the q
Externí odkaz:
https://doaj.org/article/2c5b668bdafa4071a151ceea145e9702
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2538 (2024)
Deep learning is a machine learning technique to model high-level abstractions in data by utilizing a graph composed of multiple processing layers that experience various linear and non-linear transformations. This technique has been shown to perform
Externí odkaz:
https://doaj.org/article/925ab5b1d2ef41f1891e79a342fe000a
Publikováno v:
Neurobiology of Disease, Vol 184, Iss , Pp 106201- (2023)
Neurobiological disorders are highly prevalent medical conditions that contribute to significant morbidity and mortality. Single-cell RNA sequencing (scRNA-seq) is a technique that measures gene expression in individual cells. In this review, we surv
Externí odkaz:
https://doaj.org/article/8af481a83fc04b1dbdd61f370f39bef8
Publikováno v:
Life, Vol 12, Iss 12, p 1967 (2022)
The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and medullobla
Externí odkaz:
https://doaj.org/article/a9ba1dc8889444d5bc7e862237eb37ee
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Glioblastoma (GBM) is a devastating adult brain cancer with high rates of recurrence and treatment resistance. Cellular heterogeneity and extensive invasion of surrounding brain tissues are characteristic features of GBM that contribute to its intrac
Externí odkaz:
https://doaj.org/article/941d9685f6d34b4082b27373b4af79c7
Publikováno v:
Neurobiology of Disease, Vol 145, Iss , Pp 105060- (2020)
Clinical studies have shown that treating many primary brain tumors is challenging due in part to the lack of safe and effective compounds that cross the blood brain barrier (BBB) (Tan et al., 2018). However, if we were to imagine that we have ideal
Externí odkaz:
https://doaj.org/article/a50a429195614eb289177b192694fc4e
Autor:
Fan Yang, Jezabel Rodriguez-Blanco, Jun Long, Marzena Swiderska-Syn, Daniel T. Wynn, Bin Li, Chen Shen, Anmada Nayak, Yuguang Ban, Xiaodian Sun, Robert K. Suter, Heather J. McCrea, Anthony J. Capobianco, Nagi G. Ayad, David J. Robbins
Publikováno v:
Mol Cancer Res
Dysregulation of Sonic hedgehog (SHH) signaling drives the growth of distinct cancer subtypes, including medulloblastoma (MB). Such cancers have been treated in the clinic with a number of clinically relevant SHH inhibitors, the majority of which tar