Výsledky vyhledávání - "Nagi F Idris"

Akademický článek

Comparison of the efficacy of two anticonvulsants, phenytoin and valproate to improve PCP and d-amphetamine induced deficits in a reversal learning task in the rat

Autor: Nagi F Idris, JO C Neill, Charles H Large

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 3 (2009)

Recent studies in our laboratory have shown that PCP (phencyclidine) and d-amphetamine induce a cognitive deficit in rats, in a paradigm of potential relevance for the pathology of schizophrenia. Atypical, but not classical antipsychotics and the ant

Externí odkaz: https://doaj.org/article/cbb1b654c2104dbbadce1f46a66c474f

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(3S)‐3‐(2,3‐difluorophenyl)‐3‐methoxypyrrolidine (IRL752) —a Novel Cortical-Preferring Catecholamine Transmission- and Cognition-Promoting Agent

Autor: Jenny Gunnergren, Malin Edling, Stephan Hjorth, Anne Fagerberg, Samantha L. McLean, Nicholas Waters, Boel Svanberg, Peder Svensson, Joanna C. Neill, Elisabeth Ljung, Clas Sonesson, Ben Grayson, Nagi F Idris, Susanna Waters, Joakim Tedroff

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 374:404-419

Here we describe for the first time the distinctive pharmacological profile for (3S)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine (IRL752), a new phenyl-pyrrolidine derivative with regioselective central nervous system transmission-enhancing propertie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5b198d7b7818290225bea3098e18b26
https://doi.org/10.1124/jpet.120.000037

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Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model

Autor: Matthew Burgess, Nagi F Idris, Ben Grayson, Idil Mitsadali, Joanna C. Neill, Linzi Watson

Publikováno v: Neill, J, Grayson, B, Idris, N, Watson, L, Burgess, M & Mitsadali, I 2020, ' Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model ', Journal of psychopharmacology (Oxford, England), vol. 34, no. 7, pp. 695-708 . https://doi.org/10.1177/0269881120922963

Introduction and objectives: Cognitive impairment associated with schizophrenia (CIAS) greatly reduces patients’ functionality, and remains an unmet clinical need. The sub-chronic phencyclidine (scPCP) rat model is commonly employed in studying CIA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3810e55d87e0d23794092386211c0d2f
https://doi.org/10.1177/0269881120922963

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Photocatalysis of β-blockers – An overview

Autor: Vamsi Krishna Marothu, Nagi F. Idris, Salah Ali M. Idris, Ravi Kiran Chowdary Lella, Madhavi Gorrepati

Publikováno v: Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 1290-1297 (2019)

Photocatalysis is one of the most effective advanced oxidation processes to remove residual pharmaceuticals from the aquatic environment. β-Blockers are the group of pharmaceuticals commonly found in the environment and are showing potential risk to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d7dd70ca7160db37707708e88a0074
https://doi.org/10.1016/j.arabjc.2014.10.044

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Atypical Antipsychotic Prevents and Reverses Negative Symptoms in Models of Schizophrenia

Autor: Nagi F. Idris

Introduction: Negative symptoms associated with cognitive impairment as a core symptom of schizophrenia with significant poor quality of life and remain an unmet clinical need. Administration of N-methyl-D-aspartate (NMDA) receptor antagonists in rod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2659::b0b3b1f6405b3292994629d433a7503d
https://zenodo.org/record/825608

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Deficits in social behavioral tests in a mouse model of alternating hemiplegia of childhood

Autor: Greer S. Kirshenbaum, John C. Roder, Nagi F. Idris, James Dachtler, Steven J. Clapcote

Publikováno v: Journal of Neurogenetics

Social behavioral deficits have been observed in patients diagnosed with alternating hemiplegia of childhood (AHC), rapid-onset dystonia-parkinsonism and CAPOS syndrome, in which specific missense mutations in ATP1A3, encoding the Na(+), K(+)-ATPase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0da0fd48b194e8a49f3174ce906d8e94
https://pubmed.ncbi.nlm.nih.gov/27276195

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Activation of α7 nicotinic receptors improves phencyclidine-induced deficits in cognitive tasks in rats: Implications for therapy of cognitive dysfunction in schizophrenia

Autor: Darrel J. Pemberton, Nagi F. Idris, Samantha L. McLean, Ben Grayson, Anne S. J. Lesage, Jo C. Neill, Claire Mackie

Publikováno v: European Neuropsychopharmacology. 21:333-343

Nicotinic α7 acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia.To investigate whether the deficits induced by sub-chronic phencyclidine (PCP) in reversal learning and novel object recogniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7890b00dcf2ebd787ffafd7645d222
https://doi.org/10.1016/j.euroneuro.2010.06.003

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Animal models of cognitive dysfunction and negative symptoms of schizophrenia: Focus on NMDA receptor antagonism

Autor: Ben Grayson, Lakshmi Rajagopal, Michael K. Harte, Shikha Snigdha, Samuel A. Barnes, Samantha R. Cook, Nagi F. Idris, Joanna C. Neill, Samantha L. McLean

Publikováno v: Pharmacology & Therapeutics. 128:419-432

Cognitive deficits in schizophrenia remain an unmet clinical need. Improved understanding of the neuro- and psychopathology of these deficits depends on the availability of carefully validated animal models which will assist the development of novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6c3e0ab7c84e0ef221a48e19316847
https://doi.org/10.1016/j.pharmthera.2010.07.004

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