Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nageswari Yarravarapu"'
Autor:
Ajaz A. Bhat, Sabah Nisar, Soumi Mukherjee, Nirmalya Saha, Nageswari Yarravarapu, Saife N. Lone, Tariq Masoodi, Ravi Chauhan, Selma Maacha, Puneet Bagga, Punita Dhawan, Ammira Al-Shabeeb Akil, Wael El-Rifai, Shahab Uddin, Ravinder Reddy, Mayank Singh, Muzafar A. Macha, Mohammad Haris
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Gene editing has great potential in treating diseases caused by well-characterized molecular alterations. The introduction of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9)–based gene-
Externí odkaz:
https://doaj.org/article/5c11bfa5c37549b0b549f3c86a885fe3
Autor:
Nageswari Yarravarapu, Rohit Sai Reddy Konada, Narek Darabedian, Nichole J. Pedowitz, Soumya N. Krishnamurthy, Matthew R. Pratt, Jennifer J. Kohler
Publikováno v:
Bioconjug Chem
Glycan binding often mediates extracellular macromolecular recognition events. Accurate characterization of these binding interactions can be difficult because of dissociation and scrambling that occur during purification and analysis steps. Use of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082c6963e2635aa1064f03b98fcdedc0
https://doi.org/10.1021/acs.bioconjchem.2c00037
https://doi.org/10.1021/acs.bioconjchem.2c00037
Autor:
Emma G. Jackson, Giuliano Cutolo, Bo Yang, Nageswari Yarravarapu, Mary W. N. Burns, Ganka Bineva-Todd, Chloë Roustan, James B. Thoden, Halley M. Lin-Jones, Toin H. van Kuppevelt, Hazel M. Holden, Benjamin Schumann, Jennifer J. Kohler, Christina M. Woo, Matthew R. Pratt
Publikováno v:
Acs Chemical Biology, 17, 159-170
ACS Chemical Biology
Acs Chemical Biology, 17, 1, pp. 159-170
ACS Chemical Biology
Acs Chemical Biology, 17, 1, pp. 159-170
Bio-orthogonal chemistries have revolutionized many fields. For example, metabolic chemical reporters (MCRs) of glycosylation are analogues of monosaccharides that contain a bio-orthogonal functionality, such as azides or alkynes. MCRs are metabolica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09a6b42fdce89cd311e21d1c951f3f50
http://hdl.handle.net/2066/247897
http://hdl.handle.net/2066/247897
Autor:
Lawrence G. Lum, Jeremiah Herbert, Yuyong Ma, Chuo Chen, Chengwei Zhang, James Kim, Nageswari Yarravarapu, Rubina Tuladhar
Publikováno v:
Journal of Biological Chemistry. 294:6273-6282
The maintenance of adult animal tissues depends upon highly conserved intercellular signaling molecules that include the secreted WNT proteins. Although it is generally accepted that lipidation of WNTs by the acyltransferase Porcupine (PORCN) and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb2afb4abe25cb5b5cc5ab2a20f1288
https://doi.org/10.1074/jbc.ra118.007268
https://doi.org/10.1074/jbc.ra118.007268
Autor:
Hua Chen, Lawrence G. Lum, Jeremiah Herbert, Kiyoshi Yamaguchi, Nageswari Yarravarapu, Pranathi Dasari, Xuewu Zhang, Ozlem Kulak, Chen Fan
Publikováno v:
Biochemical and Biophysical Research Communications. 503:1780-1785
Tankyrases (TNKS and TNKS2) are enzymes that catalyze poly-ADP-ribosylation (PARsylation) of their target proteins. Tankyrase-mediated PARsylation plays critical regulatory roles in cell signaling, particularly in the Wnt/β-catenin pathway. The ster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5173d3dad9b331fb3deae8586ace347b
https://doi.org/10.1016/j.bbrc.2018.07.113
https://doi.org/10.1016/j.bbrc.2018.07.113
Autor:
Lawrence G. Lum, Chengwei Zhang, Xiaolei Wang, Nageswari Yarravarapu, Lin You, Lishu Zhang, Noelle S. Williams, Chuo Chen, Lorraine Morlock
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5891-5895
The acyltransferase Porcupine (Porcn) is essential for the secretion of Wnt proteins which contribute to embryonic development, tissue regeneration, and tumorigenesis. We have previously discovered four molecular scaffolds harboring Porcn-inhibitory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c0834317fcad6bb8306b56034afcdaf
https://doi.org/10.1016/j.bmcl.2016.11.012
https://doi.org/10.1016/j.bmcl.2016.11.012
Autor:
Nageswari Yarravarapu, James Kim, Lawrence G. Lum, Chen Fan, Ozlem Kulak, Haolin Shi, Chuo Chen
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
Mutations in components of the Hedgehog (HH) signal transduction pathway are found in the majority of basal cell carcinoma (BCC) and medulloblastoma incidents. Cancerous cells with intrinsic or acquired resistance to antagonists targeting the seven t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea6456b762adb96e00791b0faff112e
https://doi.org/10.1038/s41598-018-19408-9
https://doi.org/10.1038/s41598-018-19408-9
Publikováno v:
Methods in Molecular Biology ISBN: 9781493963911
We describe here a technique for visualizing the lipidation status of Wnt proteins using azide-alkyne cycloaddition chemistry (click chemistry) and SDS-PAGE. This protocol incorporates in vivo labeling of a Wnt-IgG Fc fusion protein using an alkynyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b676be436bb2790eda7ad31d3c386c
https://doi.org/10.1007/978-1-4939-6393-5_2
https://doi.org/10.1007/978-1-4939-6393-5_2
Publikováno v:
Tetrahedron. 68:2925-2942
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2c8bf36962f1102d65e0ba91f57bd9b
https://doi.org/10.1016/j.tet.2012.02.001
https://doi.org/10.1016/j.tet.2012.02.001
Autor:
Tuladhar, Rubina1, Nageswari Yarravarapu1, Yuyong Ma2, Chengwei Zhang2, Herbert, Jeremiah1, Kim, James3,4 james.kim@utsouthwestern.edu, Chuo Chen2 chuo.chen@utsouthwestern.edu, Lum, Lawrence1 lawrence.lum@utsouthwestern.edu
Publikováno v:
Journal of Biological Chemistry. 4/19/2019, Vol. 294 Issue 16, p6223-6282. 10p.