Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Nageswararao, Chilukuri"'
Autor:
Reena Goswami, Gayatri Subramanian, Liliya Silayeva, Isabelle Newkirk, Deborah Doctor, Karan Chawla, Saurabh Chattopadhyay, Dhyan Chandra, Nageswararao Chilukuri, Venkaiah Betapudi
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The human genetic code encrypted in thousands of genes holds the secret for synthesis of proteins that drive all biological processes necessary for normal life and death. Though the genetic ciphering remains unchanged through generations, some genes
Externí odkaz:
https://doaj.org/article/da28ef60e1604343b7dff03876f58c0c
Publikováno v:
Science Translational Medicine. 12
Chemical warfare nerve agents are organophosphorus chemical compounds that induce cholinergic crisis, leaving little or no time for medical intervention to prevent death. The current chemical treatment regimen may prevent death but does not prevent p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00f54b4a0d8e71c05a9f0386bcec4ad
https://doi.org/10.1126/scitranslmed.aay0356
https://doi.org/10.1126/scitranslmed.aay0356
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16545 (2011)
Senescence marker protein (SMP30), also known as regucalcin, is a 34 kDa cytosolic marker protein of aging which plays an important role in intracellular Ca(2+) homeostasis, ascorbic acid biosynthesis, oxidative stress, and detoxification of chemical
Externí odkaz:
https://doaj.org/article/3d4bc5b97eb745c5b8b85ffdefa4701c
Autor:
Isabelle Newkirk, Reena Goswami, Nageswararao Chilukuri, Saurabh Chattopadhyay, Deborah M. Doctor, Venkaiah Betapudi, Dhyan Chandra, Gayatri Subramanian, Liliya Silayeva, Karan Chawla
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 9 (2019)
Frontiers in Oncology, Vol 9 (2019)
The human genetic code encrypted in thousands of genes holds the secret for synthesis of proteins that drive all biological processes necessary for normal life and death. Though the genetic ciphering remains unchanged through generations, some genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6886a413ee6b6dd1a9b36ab8b6623a
http://europepmc.org/articles/PMC6491712
http://europepmc.org/articles/PMC6491712
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 349:549-558
We investigated the ability of the engineered paraoxonase-1 variants G3C9, VII-D11, I-F11, and VII-D2 to afford protection against paraoxon intoxication. Paraoxon is the toxic metabolite of parathion, a common pesticide still in use in many developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d131282fbcc458eb2ea152c225ad92
https://doi.org/10.1124/jpet.114.213645
https://doi.org/10.1124/jpet.114.213645
Publikováno v:
Chemico-Biological Interactions. 203:191-195
Human liver prolidase, a metal-dependent dipeptidase, is being tested as a potential catalytic bioscavenger against organophosphorus (OP) chemical warfare nerve agents. The purpose of this study was to determine whether persistent and high-levels of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1fc2f4381936d527258d626d0f25d6
https://doi.org/10.1016/j.cbi.2012.08.021
https://doi.org/10.1016/j.cbi.2012.08.021
Autor:
Peter Rezk, Tony E. Reeves, Zeke P. Oliver, Joshua Harrison, Shane A. Kasten, Nageswararao Chilukuri, Tamara C. Otto, Douglas M. Cerasoli, Sean M. Hodgins
Publikováno v:
Chemico-Biological Interactions. 203:177-180
Human paraoxonase-1 (HuPON1) has been proposed as a catalytic bioscavenger of organophosphorus (OP) pesticides and nerve agents. We assessed the potential of this enzyme to protect against OP poisoning using two different paradigms. First, recombinan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e3ae1ca69594e7f48e27edb9f4675c
https://doi.org/10.1016/j.cbi.2012.10.015
https://doi.org/10.1016/j.cbi.2012.10.015
Publikováno v:
Chemico-biological interactions. 259
We evaluated the ability of evolved paraoxonase-1 (PON1) to afford broad spectrum protection against G-type nerve agents when produced in mammalian cells via an adenovirus expression system. The PON1 variants G3C9, VII-D11, I-F11, VII-D2 and II-G1 we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0d64133725d823c2d0fcd27acd0571
https://pubmed.ncbi.nlm.nih.gov/27083144
https://pubmed.ncbi.nlm.nih.gov/27083144
Autor:
Oksana Lockridge, Kalpana Parikh, Neil S. Jensen, Veeraswamy Manne, Ellen G. Duysen, Nageswararao Chilukuri, Benjamin Snow
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 337:92-101
Gene delivery using an adenoviral system has been effective in introducing therapeutic proteins in vitro and in vivo. This study tested the feasibility of using adenovirus to deliver clinically relevant amounts of butyrylcholinesterase (BChE), a prov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90f7281c1cd6e944f663340a2612a25b
https://doi.org/10.1124/jpet.110.175646
https://doi.org/10.1124/jpet.110.175646
Publikováno v:
Biochemical and Biophysical Research Communications. 393:509-513
Senescence marker protein-30 (SMP30) has been reported to hydrolyze diisopropyl fluorophosphate (DFP), a surrogate compound of chemical warfare nerve agents. Thus, SMP30 has the potential to be useful as a prophylactic against chemical warfare nerve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074d492e0e6846273c57ec66ea17afed
https://doi.org/10.1016/j.bbrc.2010.02.036
https://doi.org/10.1016/j.bbrc.2010.02.036