Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nagendran Muthusamy"'
Autor:
Nagendran Muthusamy, Taufika I. Williams, Ryan O’Toole, Jon J. Brudvig, Kenneth B. Adler, Jill M. Weimer, David C. Muddiman, H. Troy Ghashghaei
Publikováno v:
GeroScience
Ependymal cells (ECs) line the ventricular surfaces of the mammalian central nervous system (CNS) and their development is indispensable to structural integrity and functions of the CNS. We previously reported that EC-specific genetic deletion of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80c229db3a11a55ee611c46cc0d4696f
https://doi.org/10.1007/s11357-022-00517-3
https://doi.org/10.1007/s11357-022-00517-3
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 90:93-102
The neuron-enriched, endosomal protein Calcyon (Caly) regulates endocytosis and vesicle sorting, and is important for synaptic plasticity and brain development. In the current investigation of Caly interacting proteins in brain, the microtubule retro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfd66325c1db116352d2ae97783e740
https://doi.org/10.1016/j.biocel.2017.07.005
https://doi.org/10.1016/j.biocel.2017.07.005
Publikováno v:
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b404317de03e0249cb30fe4a7c337413
http://europepmc.org/articles/PMC5789075
http://europepmc.org/articles/PMC5789075
Autor:
Perry J. Blackshear, Adam J. Moeser, H. Troy Ghashghaei, Nagendran Muthusamy, Kenneth B. Adler, Deborah J. Stumpo, Laura J. Sommerville, Philip L. Sannes, Jill M. Weimer
Publikováno v:
Aging Cell
Ependymal cells (ECs) form a barrier responsible for selective movement of fluids and molecules between the cerebrospinal fluid and the central nervous system. Here, we demonstrate that metabolic and barrier functions in ECs decline significantly dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f74b4858344da9f7b1d8fdf4c8e5dec
https://doi.org/10.1111/acel.12354
https://doi.org/10.1111/acel.12354
Publikováno v:
Journal of Neurochemistry. 132:20-31
Understanding mechanisms governing the trafficking of transmembrane (TM) cargoes to synapses and other specialized membranes in neurons represents a long-standing challenge in cell biology. Investigation of the neuron-enriched endosomal protein of 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6e7c66965c613d375750f444a1daf9
https://doi.org/10.1111/jnc.12989
https://doi.org/10.1111/jnc.12989
Autor:
Alexander M. Bernstein, Michael V. Sofroniew, Joshua E. Burda, Nagendran Muthusamy, Liming Cheng, S. Thomas Carmichael, H. Troy Ghashghaei, Yilong Ren, Timothy M. O’Shea, Yan Ao, Andrew J Brumm
Publikováno v:
Scientific reports, vol 7, iss 1
Scientific Reports
Scientific Reports
Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferated scar-forming astrocytes that protect tissue and function after spinal cord injury (SCI). This proposal was based on small, midline stab SCI. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1712445084339b3fd7d85ddc1f498dfa
https://escholarship.org/uc/item/2r72t61g
https://escholarship.org/uc/item/2r72t61g
Publikováno v:
genesis. 52:350-358
The transcription factor Foxj1 is expressed by cells destined to differentiate into epithelial cells projecting motile cilia into fluid- or air-filled cavities. Here, we report the generation of an inducible knock-in Foxj1(CreERT2::GFP) mouse, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::742a82dce21fdac768cedd8fce1f2d90
https://doi.org/10.1002/dvg.22753
https://doi.org/10.1002/dvg.22753
Publikováno v:
Nature neuroscience
Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1911fd09734c4ea26eb3b55b3cbdb3b0
https://pubmed.ncbi.nlm.nih.gov/27918532
https://pubmed.ncbi.nlm.nih.gov/27918532
Autor:
Hiroshi Hanafusa, Sho Morioka, H. Troy Ghashghaei, Nagendran Muthusamy, Kazuhito Sai, Kunihiro Matsumoto, Jun Ninomiya-Tsuji, Giichi Takaesu
Publikováno v:
Journal of Cell Science.
Sustained endoplasmic reticulum (ER) stress disrupts normal cellular homeostasis and leads to the development of many types of human diseases, including metabolic disorders. TAK1 (also known as MAP3K7) is a member of the mitogen-activated protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0c247aa2aa7c54e233eebba1cf7ec6c
https://doi.org/10.1242/jcs.180505
https://doi.org/10.1242/jcs.180505
Publikováno v:
Journal of Neurochemistry. 123:60-72
Calcyon is a neural enriched, single transmembrane protein that interacts with clathrin light chain and stimulates clathrin assembly and clathrin-mediated endocytosis. A similar property is shared by the heterotetrameric adaptor protein (AP) complexe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99dcc55534f75c7a7c445b4b8d3a9a3d
https://doi.org/10.1111/j.1471-4159.2012.07814.x
https://doi.org/10.1111/j.1471-4159.2012.07814.x