Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nagendra Yaluri"'
Autor:
Nagendra Yaluri, Alena Stančáková Yaluri, Pavol Žeňuch, Zuzana Žeňuchová, Štefan Tóth, Peter Kalanin
Publikováno v:
Diagnostics, Vol 13, Iss 15, p 2508 (2023)
Cardiovascular disease (CVD) is a global health concern, causing significant morbidity and mortality. Both lifestyle and genetics influence the development of CVD. It is often diagnosed late, when the treatment options are limited. Early diagnosis of
Externí odkaz:
https://doaj.org/article/e16ad859366a44669f18d2ecc3943393
Autor:
Nagendra Yaluri, Shalem Modi, Maykel López Rodríguez, Alena Stančáková, Johanna Kuusisto, Tarja Kokkola, Markku Laakso
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142902 (2015)
Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current stud
Externí odkaz:
https://doaj.org/article/516e1a0f32324b67a44de59cc9a622ae
Publikováno v:
Biochemical and Biophysical Research Communications. 480:194-200
Article
Simvastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor widely used for the treatment of hypercholesterolemia. Recent data indicates that simvastatin increases the risk of new-onset diabetes by impairing both insulin secretio
Simvastatin is a 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor widely used for the treatment of hypercholesterolemia. Recent data indicates that simvastatin increases the risk of new-onset diabetes by impairing both insulin secretio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2914cdfc787dab7c5a9ba30078e06344
https://doi.org/10.1016/j.bbrc.2016.10.026
https://doi.org/10.1016/j.bbrc.2016.10.026
Publikováno v:
Biochemical and biophysical research communications. 499(2)
Obesity is characterized by excess fat accumulation in white adipose tissue, which triggers chronic low-grade inflammation through secretion of pro-inflammatory factors by the enlarged adipocytes and infiltrated macrophages. This affects glucose and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b761797f2716b009ada86f64c1c61367
https://pubmed.ncbi.nlm.nih.gov/29550483
https://pubmed.ncbi.nlm.nih.gov/29550483
Autor:
Shalem Modi, Henna Cederberg, Nagendra Yaluri, Johanna Kuusisto, Markku Laakso, Alena Stančáková
Publikováno v:
Diabetologia. 58:1109-1117
Aims/hypothesis The aim of this work was to investigate the mechanisms underlying the risk of type 2 diabetes associated with statin treatment in the population-based Metabolic Syndrome in Men (METSIM) cohort. Methods A total of 8,749 non-diabetic pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be60d3fb31cc670b4a06b93fe4b05781
https://doi.org/10.1007/s00125-015-3528-5
https://doi.org/10.1007/s00125-015-3528-5
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Insulin resistance is a characteristic finding in hyperglycaemia and type 2 diabetes. SIRT1 is a NAD+ dependent deacetylase that plays a central role in glucose homeostasis and energy metabolism. SIRT1 activators, including plant polyphenols such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f561f2e22123c75711a1a02da531a969
https://pubmed.ncbi.nlm.nih.gov/29242624
https://pubmed.ncbi.nlm.nih.gov/29242624
Autor:
Tea Tiilikainen, Hilkka Soininen, Pasi Miettinen, Marine Krzisch, Saila Vepsäläinen, Markku Laakso, Henna Koivisto, Annakaisa Haapasalo, Petra Mäkinen, Vinoth Kumar Megraj Khandelwal, Mikko Hiltunen, Heikki Tanila, Nagendra Yaluri, Maija Tusa, Susanna Kemppainen
Publikováno v:
Journal of Cellular and Molecular Medicine
According to epidemiological studies, type-2 diabetes increases the risk of Alzheimer’s disease. Here, we induced hyperglycaemia in mice overexpressing mutant amyloid precursor protein and presenilin-1 (APdE9) either by cross-breeding them with pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ac234cd344ca4e0a31126223258764
http://europepmc.org/articles/PMC3823075
http://europepmc.org/articles/PMC3823075
Autor:
Johanna Kuusisto, Maykel López Rodríguez, Tarja Kokkola, Alena Stančáková, Markku Laakso, Shalem Modi, Nagendra Yaluri
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 11, p e0142902 (2015)
PLoS ONE, Vol 10, Iss 11, p e0142902 (2015)
Statins are widely used in the treatment of hypercholesterolemia and are efficient in the prevention of cardiovascular disease. Molecular mechanisms explaining statin-induced impairment in insulin secretion remain largely unknown. In the current stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90798ef97694837a855568240c19319
https://pubmed.ncbi.nlm.nih.gov/26561346
https://pubmed.ncbi.nlm.nih.gov/26561346
Autor:
Sami Heikkinen, Marc Cerrada-Gimenez, Teemu Kuulasmaa, Paula Itkonen, Nagendra Yaluri, Leena Alhonen, Tatu A. Miettinen, Maija Tusa, Jussi Pihlajamäki, Markku Laakso, Helena Gylling, Juhani Jänne, Eija Pirinen, Marko Pietilä
Publikováno v:
Amino acids. 38(2)
Transgenic mice with activated polyamine catabolism due to overexpression of spermidine/spermine N(1)-acetyltransferase (SSAT) have significantly reduced plasma total cholesterol levels. In our study, we show that low cholesterol levels were attribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b635dd6ce96460743c556f0899128c1
https://pubmed.ncbi.nlm.nih.gov/19956992
https://pubmed.ncbi.nlm.nih.gov/19956992
Autor:
Christoph H. Westphal, Marie Lagouge, Shalem Modi, Markku Vänttinen, Nagendra Yaluri, David A. Sinclair, Paula Itkonen, Jussi Pihlajamäki, Sakari Kainulainen, Markku Laakso, Peter J. Elliott, Johan Auwerx, Hiroyasu Yamamoto, Jarno Rutanen
Publikováno v:
Diabetes
OBJECTIVE Sirtuin 1 (SIRT1) is implicated in the regulation of mitochondrial function, energy metabolism, and insulin sensitivity in rodents. No studies are available in humans to demonstrate that SIRT1 expression in insulin-sensitive tissues is asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e9ee6b50023a46d5d9ed1e60d23678
https://infoscience.epfl.ch/record/147169
https://infoscience.epfl.ch/record/147169
