Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

Autor: Rui Wang, Nagendra Reddy Chintam, Joshua Rokach, Qiuji Ye, Sylvie Gravel, Shishir Chourey, William S. Powell

Publikováno v: Bioorganicmedicinal chemistry letters. 27(20)

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8486dc0feab6dfc5e39e7908640af87d
https://pubmed.ncbi.nlm.nih.gov/28943042

Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

Autor: Cossette C; Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre , 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1, Canada., Chourey S; Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology , 150 West University Boulevard, Melbourne, Florida 32901-6982, United States., Ye Q; Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology , 150 West University Boulevard, Melbourne, Florida 32901-6982, United States., Nagendra Reddy C; Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology , 150 West University Boulevard, Melbourne, Florida 32901-6982, United States., Gore V; Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology , 150 West University Boulevard, Melbourne, Florida 32901-6982, United States., Gravel S; Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre , 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1, Canada., Slobodchikova I; Department of Chemistry and Biochemistry and PERFORM Centre, Concordia University , 7141 Sherbrooke Street West, Montréal, Quebec H4B 1R6, Canada., Vuckovic D; Department of Chemistry and Biochemistry and PERFORM Centre, Concordia University , 7141 Sherbrooke Street West, Montréal, Quebec H4B 1R6, Canada., Rokach J; Claude Pepper Institute and Department of Chemistry, Florida Institute of Technology , 150 West University Boulevard, Melbourne, Florida 32901-6982, United States., Powell WS; Meakins-Christie Laboratories, Centre for Translational Biology, McGill University Health Centre , 1001 Decarie Boulevard, Montreal, Quebec H4A 3J1, Canada.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2016 Nov 23; Vol. 59 (22), pp. 10127-10146. Date of Electronic Publication: 2016 Nov 07.