Výsledky vyhledávání

Contribution of newly synthesized cholesterol to rat plasma and bile determined by mass isotopomer distribution analysis: bile-salt flux promotes secretion of newly synthesized cholesterol into bile

Autor: Bandsma, RHJ, Stellaard, F, Vonk, RJ, Nagel, GT, Neese, RA, Hellerstein, MK, Kuipers, F

Publikováno v: Biochemical Journal, 329, 699-703. PORTLAND PRESS LTD

To quantify the contribution of newly synthesized cholesterol to total plasma and biliary cholesterol under physiological conditions, unrestrained rats were infused intravenously with [1-C-13]acetate (0.6 mmol/h per kg) from 12:00 to 24:00 h, and fra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e95a70d76d73d53f57cc779d1b9c5b7d
https://research.rug.nl/en/publications/21e6a394-a6e1-4c6a-ab42-4c482f4f2518

Zobrazit plný text záznamu

THE DETERMINATION OF DELTA-5-ANDROSTENEDIOL AND ITS SULFATE IN SERUM AND URINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

Autor: DIKKESCHEI, LD, WOLTHERS, BG, WILLEMSE, PHB, VANDERPOL, H, DERUYTERBUITENHUIS, AW, NAGEL, GT

Publikováno v: Clinical Endocrinology, 39(4), 469-474. Wiley

OBJECTIVES We developed an assay for delta-5-androstenediol (adiol) and delta-5-androstenediol-3-sulphate (adiol-3S) in serum and adiol and total adiol sulphate (adiol-S) in urine. DESIGN An analytical procedure using HPLC and gas chromatography-mass

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::2d8feadcef0925a7609366f788eeefd7
https://research.rug.nl/en/publications/51ed9c86-8cc5-4c09-b8d7-66a38b7cc715

Zobrazit plný text záznamu

DELTA-5-ANDROSTENEDIOL AND ITS SULFATE IN SERUM AND URINE OF NORMAL ADULTS AND PATIENTS WITH ENDOCRINE DISEASES

Autor: DIKKESCHEI, LD, WILLEMSE, PHB, WOLTHERS, BG, DERUYTERBUITENHUIS, AW, NAGEL, GT

Publikováno v: Clinical Endocrinology, 39(4), 475-482. Wiley

OBJECTIVES We evaluated the role of delta-5-androstenediol (adiol) and its sulphates in health and endocrine diseases. DESIGN Serum and urine samples from healthy adult men and pre and post-menopausal women were analysed by gas chromatography-mass sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::36c22735fe3c3263566a649413ffaf53
https://research.rug.nl/en/publications/9974d4e3-574a-40d5-8684-df2bc6e8021c

Zobrazit plný text záznamu

SYNTHESIS AND CHARACTERIZATION OF THE 6-ALPHA-HYDROXYLATED AND 6-BETA-HYDROXYLATED DERIVATIVES OF CORTICOSTERONE, 11-DEHYDROCORTICOSTERONE, AND 11-DEOXYCORTISOL

Autor: KRAAN, GPB, VANWEE, KT, WOLTHERS, BG, VANDERMOLEN, JC, NAGEL, GT, DRAYER, NM, VANLEUSEN, D

Publikováno v: Steroids, 58(10), 495-503. ELSEVIER SCIENCE INC

This report describes the synthesis of 6alpha,17,21- and 6beta,17,21-trihydroxypregn-4-ene-3,20-dione, 6alpha,7,21- and 6beta,11beta,21-trihydroxypregn-4-ene-3,20-dione, and-for the first time-that of 6alpha,21- and 6beta,21-dihydroxypregn-4-ene-3,11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::71f4246b9725a54b29f4c27be50d44ab
https://research.rug.nl/en/publications/f35f1ba1-369f-4243-b04c-1e0d250db5eb

Zobrazit plný text záznamu

Isotope dilution ammonia chemical ionization mass fragmentographic analysis of urinary 3-O-methylated catecholamine metabolites: Rapid sample clean-up by derivatization and extraction of lyophilized samples

Autor: Kema, I.P., Meiborg, G., Nagel, GT., Stob, G.J., Muskiet, F.A.J.

Publikováno v: Journal of chromatography-Biomedical applications, 617(2), 181-189

We developed a method for simultaneous quantification of the urinary 3-O-methylated catecholamine metabolites 3-methoxytyramine, normetanephrine and metanephrine by stable isotope-dilution ammonia chemical ionization mass fragmentography. Prepurifica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::7f9addbb3170e4bafbec82b4d2bffbc4
https://research.rug.nl/en/publications/be268bfd-16aa-44a6-b396-b886f464b6b3

Zobrazit plný text záznamu

NEW IDENTIFIED 15-BETA-HYDROXYLATED 21-DEOXY-PREGNANES IN CONGENITAL ADRENAL-HYPERPLASIA DUE TO 21-HYDROXYLASE DEFICIENCY

Autor: KRAAN, GPB, WOLTHERS, BG, VANDERMOLEN, JC, NAGEL, GT, DRAYER, NM, JOANNOU, GE

Publikováno v: Journal of steroid biochemistry and molecular biology, 45(5), 421-434. PERGAMON-ELSEVIER SCIENCE LTD

The identification of 3 new 15beta-hydroxylated 21-deoxy-pregnanes in the urinary steroid profile of a 4-month-old girl with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is reported here. These steroids were identifie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4f1c8d27a711a776c37c4c7b00160b06
https://research.rug.nl/en/publications/99d19d1f-96bb-421c-96c1-a554f2da0617

Zobrazit plný text záznamu

MEASUREMENT OF THE CORTISOL PRODUCTION-RATE IN 2 SISTERS WITH 17-ALPHA-HYDROXYLASE DEFICIENCY USING [1,2,3,4-C-13]CORTISOL AND ISOTOPE-DILUTION MASS-SPECTROMETRY

Autor: CHAPMAN, TE, KRAAN, GPB, NAGEL, GT, WOLTHERS, BG, DRAYER, NM

Publikováno v: Journal of steroid biochemistry and molecular biology, 38(4), 489-496. PERGAMON-ELSEVIER SCIENCE LTD

[1,2,3,4-C-13]cortisol was i.v. administered to two sisters aged 11 yr (patient I) and 3 yr (patient II) who suffer from 17-alpha-hydroxylase deficiency. This is the first time that the cortisol production rate (CPR) in patients with 17-alpha-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::e1608905869a267c8b868af314777c56
https://research.rug.nl/en/publications/b59bedf1-a9a7-4626-8223-d483bfaf797b

Zobrazit plný text záznamu

USE OF DETERMINATIONS OF 7-LATHOSTEROL (5-ALPHA-CHOLEST-7-EN-3-BETA-OL) AND OTHER CHOLESTEROL PRECURSORS IN SERUM IN THE STUDY AND TREATMENT OF DISTURBANCES OF STEROL-METABOLISM, PARTICULARLY CEREBROTENDINOUS XANTHOMATOSIS

Autor: WOLTHERS, BG, WALRECHT, HT, VANDERMOLEN, JC, NAGEL, GT, VANDOORMAAL, JJ, WIJNANDTS, PN

Publikováno v: Journal of Lipid Research, 32(4), 603-612. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

The sterol composition of sera from patients with cerebrotendinous xanthomatosis (CTX) was investigated by gas chromatographic analysis of saponified extracts, using a polar (CP Wax 52CB) and an apolar (CP Sil 5CB) capillary column. Apart from alread

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::cc0033e98c5151054ad63ec4c0bcdf6e
https://research.rug.nl/en/publications/11e1815f-8516-4499-86b6-e9b6dc9abf22

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání