Výsledky vyhledávání

Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia

Autor: Sato, K., Sumi-Ichinose, C., Kaji, R., Ikemoto, K., Nomura, T., Nagatsu, I., Ichinose, Hiroshi, Ito, M., Sako, W., Nagahiro, S., Graybiel, A.M., Goto, S.

Publikováno v: Proceedings of the National Academy of Sciences. 105:12551-12556

Dopa-responsive dystonia (DRD) is a hereditary dystonia characterized by a childhood onset of fixed dystonic posture with a dramatic and sustained response to relatively low doses of levodopa. DRD is thought to result from striatal dopamine deficienc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430989caacc01c7c77b17280bcd9f3c0
https://doi.org/10.1073/pnas.0806065105

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Localization of sepiapterin reductase in the human brain

Autor: Ikemoto, K., Suzuki, T., Ichinose, Hiroshi, Ohye, T., Nishimura, A., Nishi, K., Nagatsu, I., Nagatsu, T.

Publikováno v: Brain Research. 954:237-246

Sepiapterin reductase (SPR) is the enzyme that catalyzes the final step of the synthesis of tetrahydrobiopterin (BH4), the cofactor for phenylalanine hydroxylase, tyrosine hydroxylase (TH), tryptophan hydroxylase, and nitric oxide synthase (NOS). Alt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91387cddbb0165597f847b200eb6b108
https://doi.org/10.1016/s0006-8993(02)03341-3

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Behavioral Recovery in a Primate Model of Parkinson's Disease by Triple Transduction of Striatal Cells with Adeno-Associated Viral Vectors Expressing Dopamine-Synthesizing Enzymes

Autor: Muramatsu, S.-I., Kume, A., Matsumura, M., Nagatsu, I., Urano, F., Ichinose, Hiroshi, Nagatsu, T., Terao, K., Nakano, I., Ozawa, K., Fujimoto, K.-I., Ikeguchi, K., Shizuma, N., Kawasaki, K., Ono, F., Shen, Y., Wang, L., Mizukami, H.

Publikováno v: Human Gene Therapy. 13:345-354

One potential strategy for gene therapy of Parkinson's disease (PD) is the local production of dopamine (DA) in the striatum induced by restoring DA-synthesizing enzymes. In addition to tyrosine hydroxylase (TH) and aromatic-L-amino-acid decarboxylas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1da3163ea5c4b1abbc4d125a1811fe8
https://doi.org/10.1089/10430340252792486

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Triple Transduction with Adeno-Associated Virus Vectors Expressing Tyrosine Hydroxylase, Aromatic-L-Amino-Acid Decarboxylase, and GTP Cyclohydrolase I for Gene Therapy of Parkinson's Disease

Autor: Shen, Y., Nagatsu, I., Urano, F., Suzuki, T., Ichinose, Hiroshi, Nagatsu, T., Monahan, J., Nakano, I., Ozawa, K., Muramatsu, S.-I., Ikeguchi, K., Fujimoto, K.-I., Fan, D.-S., Ogawa, M., Mizukami, H., Urabe, M., Kume, A.

Publikováno v: Human Gene Therapy. 11:1509-1519

Parkinson's disease (PD), a neurological disease suited to gene therapy, is biochemically characterized by a severe decrease in the dopamine content of the striatum. One current strategy for gene therapy of PD involves local production of dopamine in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f534d11ff72aadae62612558306607
https://doi.org/10.1089/10430340050083243

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Behavioral Recovery in 6-Hydroxydopamine-Lesioned Rats by Cotransduction of Striatum with Tyrosine Hydroxylase and Aromatic l-Amino Acid Decarboxylase Genes Using Two Separate Adeno-Associated Virus Vectors

Autor: Fan, D.-S., Ogawa, M., Fujimoto, K.-I., Ikeguchi, K., Ogasawara, Y., Urabe, M., Nishizawa, M., Nakano, I., Yoshida, M., Nagatsu, I., Ichinose, Hiroshi, Nagatsu, T., Kurtzman, G.J., Ozawa, K.

Publikováno v: Human Gene Therapy. 9:2527-2535

Parkinson's disease (PD) is characterized by the progressive loss of the dopaminergic neurons in the substantia nigra and a severe decrease in dopamine in the striatum. A promising approach to the gene therapy of PD is intrastriatal expression of enz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590b757fd7a4233a58cb8876d2ea0729
https://doi.org/10.1089/hum.1998.9.17-2527

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Analysis of the alternative promoters that regulate tissue-specific expression of human aromatic L-amino acid decarboxylase

Autor: Sumi-Ichinose, C., Hasegawa, S., Ichinose, Hiroshi, Sawada, H., Kobayashi, K., Sakai, M., Fujii, T., Nomura, H., Nomura, T., Nagatsu, I., Hagino, Y., Fujita, K., Nagatsu, T.

Publikováno v: Journal of Neurochemistry. 64(No. 2):514-524

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::d75e085af4f556b1a99d21b79c1b3ba7
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100706853

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Specific localization of the guanosine triphosphate (GTP) cyclohydrolase I-immunoreactivity in the human brain

Autor: Nagatsu, I., Ikemoto, K., Kitahama, K., Nishimura, A., Ichinose, Hiroshi, Nagatsu, T.

Publikováno v: Journal of neural transmission (Vienna, Austria : 1996). 106(7-8)

Guanosine triphosphate (GTP) cyclohydrolase I (GCH) is the first and rate-limiting enzyme for biosynthesis of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase (TH). Our previous study reported the presence of GCH in several neuronal groups i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299cba0925292812b18ef0d185437343
https://pubmed.ncbi.nlm.nih.gov/10907721

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Akademický článek

S18–2 - Presence of L-DOPA-containing neurons and fibers in the brain: morphological study.

Autor: Nagatsu, I ¹, Kitahama, K ²

Publikováno v: In Japanese Journal of Pharmacology 1999 79 Supplement 1:32-32

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