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C9orf72由来のプロリン : アルギニンポリペプチドは細胞骨格とメカニカルストレス応答を制御する

Autor: Shiota, Tomo, Nagata, Riko, Kikuchi, Sotaro, Nanaura, Hitoki, Matsubayashi, Masaya, Nakanishi, Mari, Kobashigawa, Shinko, Isozumi, Noriyoshi, Kiriyama, Takao, Nagayama, Kazuaki, Sugie, Kazuma, Yamashiro, Yoshito, Mori, Eiichiro

Publikováno v: Frontiers in cell and developmental biology. 10:Article No.750829

Proline:arginine (PR) poly-dipeptides from the GGGGCC repeat expansion in C9orf72 have cytotoxicity and bind intermediate filaments (IFs). However, it remains unknown how PR poly-dipeptides affect cytoskeletal organization and focal adhesion (FA) for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::fe79711a56d0a3761e30a8d53985f7e0
http://hdl.handle.net/10564/4073

C9orf72リピート異常伸長より生じる毒性ペプチドは相分離制御因子の機能を阻害する

Autor: Nanaura, Hitoki, Kawamukai, Honoka, Fujiwara, Ayano, Uehara, Takeru, Aiba, Yuichiro, Nakanishi, Mari, Shiota, Tomo, Hibino, Masaki, Wiriyasermkul, Pattama, Kikuchi, Sotaro, Nagata, Riko, Matsubayashi, Masaya, Shinkai, Yoichi, Niwa, Tatsuya, Mannen, Taro, Morikawa, Naritaka, Iguchi, Naohiko, Kiriyama, Takao, Morishima, Ken, Inoue, Rintaro, Sugiyama, Masaaki, Oda, Takashi, Kodera, Noriyuki, Toma-Fukai, Sachiko, Sato, Mamoru, Taguchi, Hideki, Nagamori, Shushi, Shoji, Osami, Ishimori, Koichiro, Matsumura, Hiroyoshi, Sugie, Kazuma, Saio, Tomohide, Yoshizawa, Takuya, Mori, Eiichiro

Publikováno v: Nature communications. 12(1):Article No.5301

Nuclear import receptors (NIRs) not only transport RNA-binding proteins (RBPs) but also modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs). Toxic arginine-rich poly-dipeptides from C9orf72 interact with NIRs and cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=jairo_______::4295e59dddad2b420d26fe57fae65ae5
http://hdl.handle.net/10564/4009

Oleic Acid Activates Mitochondrial Energy Metabolism and Reduces Oxidative Stress Resistance in the Pancreatic β-Cell Line INS-1.

Autor: Suzuki M; Graduate School of Studies in Human Culture, Otsuma Women's University., Endo K; Faculty of Home Economics, Otsuma Women's University., Nagata R; Faculty of Home Economics, Otsuma Women's University., Iida-Tanaka N; Faculty of Home Economics, Otsuma Women's University.

Publikováno v: Biological & pharmaceutical bulletin [Biol Pharm Bull] 2024; Vol. 47 (1), pp. 145-153.