Výsledky vyhledávání - "Nagashige Omawari"

Synthesis, further biological evaluation and pharmacodynamics of newly discovered inhibitors of TNF-α production

Autor: Akihito Ogata, Junya Kato, Masaru Sakai, Takaaki Obata, Hisao Nakai, Takashi Kondo, Hiroyuki Ohno, Hideaki Mori, Nagashige Omawari, Toshiaki Matsui, Masaaki Toda, Shingo Nakatani

Publikováno v: Bioorganic & Medicinal Chemistry. 11:3937-3943

(1 S ,2 R )-2-Acylamino-1-methyl-2-phenylethyl phosphate derivatives 2a , 2b , 3a , and 5a , which are conformationally restricted and metabolically stable analogues of (2 R )-2-acylamino-2-phenylethyl phosphate derivatives 1a and 1b , are a new clas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c39d64107e45ad676329b390be8c06
https://doi.org/10.1016/s0968-0896(03)00409-7

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Highly potent inhibitors of tnf-α production. Part II: metabolic stabilization of a newly found chemical lead and conformational analysis of an active diastereoisomer

Autor: Wataru Kamoshima, Takaaki Obata, Shuichi Nakazawa, Akihito Ogata, Hideaki Mori, Takashi Kondo, Hisao Nakai, Masaaki Toda, Setsuko Fujita, Kouichiro Terai, Satoshi Itadani, Yoshitaka Nishita, Hiroyuki Ohno, Nagashige Omawari, Toshiaki Matsui, Masaru Sakai, Hiroshi Tsuruta

Publikováno v: Bioorganic & Medicinal Chemistry. 10:3787-3805

Design and synthesis of metabolically stabilized inhibitors of TNF-α production, which could be new drug candidates, are reported. Conformational analysis of an active diastereoisomer was performed based on biological evaluations of the conformation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d76cf58d7c7613fc625075b7fc98600
https://doi.org/10.1016/s0968-0896(02)00380-2

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Highly potent inhibitors of TNF-α production. Part I

Autor: Akihito Ogata, Shuichi Nakazawa, Masaaki Toda, Masaru Sakai, Takaaki Obata, Shingo Nakatani, Takashi Kondo, Nagashige Omawari, Wataru Kamoshima, Toshiaki Matsui, Yoshitaka Nishita, Kouichiro Terai, Satoshi Itadani, Hideaki Mori, Hisao Nakai, Hiroyuki Ohno

Publikováno v: Bioorganic & Medicinal Chemistry. 10:3757-3786

Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04590084d29770666fa5f653938f0042
https://doi.org/10.1016/s0968-0896(02)00381-4

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Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil

Autor: E.J. Stevens, Salina Mahmood, M. Dewhurst, Phuong A. Vo, David R. Tomlinson, Nagashige Omawari

Publikováno v: British Journal of Pharmacology. 118:186-190

1. This study examined the potential role of impaired nitric oxide production and response in the development of endoneurial ischaemia in experimental diabetes. Rats were anaesthetized (Na pentobarbitone 45 mg kg-1, diazepam 2 mg kg-1) for measuremen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063d83ddd6cad8700ed950d1eb0c6934
https://doi.org/10.1111/j.1476-5381.1996.tb15384.x

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Highly Potent Inhibitors of TNF-α Production. Part 1: Discovery of Chemical Leads

Autor: Masaru Sakai, Takaaki Obata, Akihito Ogata, Yoshitaka Nishita, Shingo Nakatani, Hisao Nakai, Hiroyuki Ohno, Masaaki Toda, Nagashige Omawari, Toshiaki Matsui, Shuichi Nakazawa, Takashi Kondo, Satoshi Itadani

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 12:903-905

The discovery of 2-acylamino-2-phenylethyl disodium phosphates 1 and 2 as structurally novel inhibitors of TNF-α production is reported. Structure–activity relationships (SARs) are also discussed.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abadf1b52084c0f9fe6c16cdfc9a2561
https://doi.org/10.1016/s0960-894x(02)00036-7

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Effect of OP-41483·α-CD, a prostacyclin analog, on a clamp-induced endothelial injury in rats

Autor: Keisuke Shinomiya, Masao Naka, Tsutomu Shiroya, Nagashige Omawari, Hideki Aishita, Buichi Fujitani, Ryoji Matsumoto

Publikováno v: Life Sciences. 53:893-900

We studied the effect of OP-41483.alpha-CD, a stable prostacyclin analog, on clamp-induced endothelial injury in rats. The injury was assessed by vascular Evans blue leakage and using a scanning electron microscope. OP-41483.alpha-CD significantly re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a3b6a8fd6863d4ae25b972423f88c4
https://doi.org/10.1016/0024-3205(93)90441-5

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Effects of OP-41483·α-CD, a stable prostacyclin analog, on cultured endothelial cell dysfunction caused by 15(S)-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) in vitro

Autor: Ryoji Matsumoto, Masao Naka, Hideki Aishita, Buichi Fujitani, Nagashige Omawari

Publikováno v: Life Sciences. 52:1257-1264

We studied the effect of OP-41483.alpha-CD, a stable prostacyclin analog, on, 15-HPETE induced bovine endothelial cell dysfunction, which was assessed by measuring a number of endothelial cells attached to plastic plates. 15-HPETE decreased the numbe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d66173da1b63f1a498f74ed03a7f1de1
https://doi.org/10.1016/s0024-3205(05)80015-3

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Effect of FOY-305 on post-operative reflux esophagitis in rats. (II). Analysis of mechanism in the pathogenesis of reflux esophagitis after total gastrectomy in rats

Autor: Shogo Inoshiri, Nagashige Omawari, Tadao Okegawa, Akiyoshi Kawasaki, Koumei Kamiyasu

Publikováno v: Folia Pharmacologica Japonica. 97:251-257

Esophagitis after total gastrectomy has been associated with biliary and pancreatic reflux into the esophagus. The purpose of this study is to clarify the effect of FOY-305 on these factors in the esophagitis. We initially produced esophagitis in rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb6d01684bc24a18431fcbb8df2758f
https://doi.org/10.1254/fpj.97.5_251

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Highly potent inhibitors of TNF-alpha production. Part I: discovery of new chemical leads and their structure-activity relationships

Autor: Toshiaki, Matsui, Takashi, Kondo, Yoshitaka, Nishita, Satoshi, Itadani, Shingo, Nakatani, Nagashige, Omawari, Masaru, Sakai, Shuichi, Nakazawa, Akihito, Ogata, Hideaki, Mori, Kouichiro, Terai, Wataru, Kamoshima, Hiroyuki, Ohno, Takaaki, Obata, Hisao, Nakai, Masaaki, Toda

Publikováno v: Bioorganicmedicinal chemistry. 10(12)

Discovery of new chemical leads of inhibitors for TNF-alpha production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::face4cd8ade7f7100e3ce41b224977a4
https://pubmed.ncbi.nlm.nih.gov/12413832

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Discovery of novel phosphonic acid derivatives as new chemical leads for inhibitors of TNF-alpha production

Autor: Masaru Sakai, Masaaki Toda, Nagashige Omawari, Hisao Nakai, Kazunori Nakamura, Hiroyuki Ohno, Toshiaki Matsui, Shinya Takahashi, Naoki Matsunaga, Wataru Kamoshima, Takaaki Obata, Kouichiro Terai

Publikováno v: Bioorganicmedicinal chemistry. 10(12)

2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-alpha production. Structural optimization was started with the chemical modification of 6. The discovery of ano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0643d89ae6f90696f7413bc93ea012c7
https://pubmed.ncbi.nlm.nih.gov/12413834

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