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pro vyhledávání: '"Nagaranjan Chandramouli"'
Autor:
Nagaranjan Chandramouli, Hermann Steller, Alfred L. Goldberg, J.F. Glickman, Nikolay V. Kukushkin, Henrik Molina, Cristinel Sandu, Chueh-Ling Kuo
Publikováno v:
Journal of Cellular and Molecular Medicine
Here, we report a novel mechanism of proteasome inhibition mediated by Thiostrepton (Thsp), which interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. We identified Thsp in a cell-based high-throughput screen using