Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Nagaraju, Poola"'
Autor:
Matthew G. Hartwig, Jacob A. Klapper, Nagaraju Poola, Amit Banga, Pablo G. Sanchez, John S. Murala, Jim L. Potenziano
Publikováno v:
Pulmonary Therapy, Vol 9, Iss 1, Pp 151-163 (2022)
Abstract Introduction Normothermic ex vivo lung perfusion (EVLP) is used to evaluate and condition donor lungs for transplantation. The objective of this study was to determine whether administration of exogenous nitric oxide during EVLP contributes
Externí odkaz:
https://doaj.org/article/c1cc3fa80b7144969493f15b58b91791
Autor:
Siqing Fu, David E. Piccioni, Hongtao Liu, Rimas V. Lukas, Santosh Kesari, Dawit Aregawi, David S. Hong, Kenichiro Yamaguchi, Kate Whicher, Yi Zhang, Yu-Luan Chen, Nagaraju Poola, John Eddy, David Blum
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract WT2725 is a Wilms’ tumor gene 1 (WT1)-derived-oligopeptide vaccine designed to induce WT1-specific cytotoxic T-lymphocytes against WT1+ tumors in human leukocyte antigen (HLA)-A*0201+ and/or HLA-A*0206+ patients. Here, we report the result
Externí odkaz:
https://doaj.org/article/60746137df784b578782dc3342f39baf
Publikováno v:
Clinical Pharmacology in Drug Development. 11:502-515
Repository corticotropin injection (RCI; Acthar Gel) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. This phase 1, single-center, open-label, randomized parallel study directly compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61bd92dd0edfab44d1be9eb0ce8b5348
https://doi.org/10.1002/cpdd.1020
https://doi.org/10.1002/cpdd.1020
Publikováno v:
Clinical Pharmacology in Drug Development
The pharmacokinetics (PK) and pharmacodynamics (PD) of clinically relevant doses of repository corticotropin injection (Acthar Gel) and synthetic ACTH1‐24 depot have not been fully characterized. We compared the steroidogenic exposure of repository
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529973090af0f4b51a42c7d0b58232f8
http://europepmc.org/articles/PMC8359281
http://europepmc.org/articles/PMC8359281
Autor:
Kate Whicher, Santosh Kesari, Hongtao Liu, Rimas V. Lukas, David S. Hong, Dawit Aregawi, Siqing Fu, David Piccioni, David Blum, Kenichiro Yamaguchi, Yi Zhang, John Eddy, Yu-Luan Chen, Nagaraju Poola
Publikováno v:
Scientific Reports
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
WT2725 is a Wilms’ tumor gene 1 (WT1)-derived-oligopeptide vaccine designed to induce WT1-specific cytotoxic T-lymphocytes against WT1+ tumors in human leukocyte antigen (HLA)-A*0201+ and/or HLA-A*0206+ patients. Here, we report the results of a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7bf47004af0f6ea527d2785874e6907
https://doi.org/10.1038/s41598-021-01707-3
https://doi.org/10.1038/s41598-021-01707-3
Publikováno v:
Clinical Pharmacokinetics
Background Elevated plasma ammonia is central to the pathogenesis of hepatic encephalopathy. Sodium phenylacetate or glycerol phenylbutyrate is approved for urea cycle disorders, but limited clinical data are available for hepatic encephalopathy. Phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5d1700449015e9003c4a42cf96c996
https://pubmed.ncbi.nlm.nih.gov/34125423
https://pubmed.ncbi.nlm.nih.gov/34125423
Autor:
Lester I. Harrison, Christian Zurth, Dale Bourg, Adel H. Karara, Linda Bourg, Nagaraju Poola, Dennis Morrison, Armen P. Melikian
Publikováno v:
The Journal of Clinical Pharmacology. 54:520-527
Two open-label, randomized, two-period, crossover studies were performed to determine the safety, delivery rates, and pharmacokinetic properties of a combination estradiol (E2)/levonorgestrel (LNG) transdermal delivery system (TDS). Study 1 enrolled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fecd405f949d83abcda24f86d9a9c99
https://doi.org/10.1002/jcph.238
https://doi.org/10.1002/jcph.238
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 28:495-505
Objective This study aimed to investigate the effect of prandial status and caloric and fat composition of meals on the pharmacokinetics of lurasidone. Methods Two randomized, open-label, crossover studies were conducted in clinically stable adults w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4fa0a292311987b86fe9c82725eda1f
https://doi.org/10.1002/hup.2338
https://doi.org/10.1002/hup.2338
Autor:
Adel H. Karara, Vladimir Hanes, Hartmut Blode, Rose Silang, Richard A. Preston, Nagaraju Poola, Alberto B. Alonso, Pingping Ni
Publikováno v:
The Journal of Clinical Pharmacology. 47:1292-1302
The effects of combination hormone therapy of drospirenone (DRSP), a novel progestin with antialdosterone properties, and 17beta-estradiol (E2) on hydrochlorothiazide (HCTZ) pharmacokinetics/pharmacodynamics versus placebo were investigated in a doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0805bf390298f61b0e48c3bddfafdc86
https://doi.org/10.1177/0091270007306560
https://doi.org/10.1177/0091270007306560
Autor:
Dawit Aregawi, Rimas V. Lukas, Yu-Luan Chen, Siqing Fu, Hongtao Liu, Nagaraju Poola, John Eddy, Ian Zhang, David Blum, Kate Whicher, Kenichiro Yamaguchi, David Piccioni
Publikováno v:
Journal of Clinical Oncology. 35:2066-2066
2066 Background: WT2725 is a Wilms’ tumor (WT1)-derived-oligopeptide vaccine intended to induce WT1 specific cytotoxic T-lymphocytes against WT1 positive tumors in HLA-A*0201+ or HLA-A*0206+. This first in human study of WT2725 was conducted to eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b3ce4e75a40894a2297ad45e48cc75f
https://doi.org/10.1200/jco.2017.35.15_suppl.2066
https://doi.org/10.1200/jco.2017.35.15_suppl.2066