Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Nagarajan Elumalai"'
Autor:
Jianhong Zhao, Xiaojun Zhou, Baoxiang Chen, Mingzhu Lu, Genxin Wang, Nagarajan Elumalai, Chenhui Tian, Jinmiao Zhang, Yanliang Liu, Zhiqiang Chen, Xinyi Zhou, Mingzhi Wu, Mengjiao Li, Edward V. Prochownik, Ali Tavassoli, Congqing Jiang, Youjun Li
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-15 (2023)
Abstract The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes encoding enzymes for peroxisomal f
Externí odkaz:
https://doaj.org/article/e6dcfc904fcf4acebbe5587ed3ec5f0d
Autor:
Nagarajan Elumalai, Angela Berg, Stefan Rubner, Linda Blechschmidt, Chen Song, Kalaiselvi Natarajan, Jörg Matysik, Thorsten Berg
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b SH2 domain. Here, we demonstrate STAT5b binding of ca
Externí odkaz:
https://doaj.org/article/7eb0fb05f08d4517a3fb77233ccd9bc2
Publikováno v:
Obesity Abstracts.
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3871-3882
The transcription factor STAT5b is an antitumor target. Recently, we presented the small molecules Stafib-1 and Stafib-2 as potent, selective inhibitors of the STAT5b SH2 domain. Here we report that halogen substitutions on the terminal phenyl ring o
Autor:
Eilidh K. Leitch, Paul T. Wan, Göran Dahl, Maria Fridén-Saxin, Helen Boyd, Ali Tavassoli, Garry Pairaudeau, Eric Valeur, Nagarajan Elumalai, Paul Clarkson
Publikováno v:
Chemical Science
A cyclic peptide IDOL homodimerization inhibitor identified from a genetically encoded SICLOPPS library is active in vitro and in cells.
Cellular uptake of circulating cholesterol occurs via the low density lipoprotein receptor (LDLR). The E3 ub
Cellular uptake of circulating cholesterol occurs via the low density lipoprotein receptor (LDLR). The E3 ub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f9d8ae83264b610bb9a793f561f9a5
https://eprints.soton.ac.uk/421740/
https://eprints.soton.ac.uk/421740/
Autor:
Ali Tavassoli, Nagarajan Elumalai, Michael J. Waring, Eliot Osher, Francisco Castillo, Garry Pairaudeau
Publikováno v:
Bioorganicmedicinal chemistry. 26(11)
We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexapeptides in combination with a bacterial reverse two-hybrid system. This c
Publikováno v:
Angewandte Chemie (International Ed. in English)
Src homology 2 (SH2) domains play a central role in signal transduction. Although many SH2 domains have been validated as drug targets, their structural similarity makes development of specific inhibitors difficult. The cancer‐relevant transcriptio
Autor:
Stefan Rubner, Nagarajan Elumalai, Kalaiselvi Natarajan, Linda Blechschmidt, Thorsten Berg, Jörg Matysik, Chen Song, Angela Berg
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
The transcription factor STAT5b is a target for tumour therapy. We recently reported catechol bisphosphate and derivatives such as Stafib-1 as the first selective inhibitors of the STAT5b SH2 domain. Here, we demonstrate STAT5b binding of catechol bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc1458b53e3b1f2e7d07b501263fc43
https://eprints.soton.ac.uk/428351/
https://eprints.soton.ac.uk/428351/
Publikováno v:
ACS chemical biology. 10(12)
Design approaches for inhibitors of protein-protein interactions are rare, but highly sought after. Here, we report that O-phosphorylation of simple derivatives of the natural products dihydrocapsaicin and N-vanillylnonanamide leads to inhibitors of
Autor:
Tad A. Holak, Nagarajan Elumalai, Felix Hausch, Weronika Janczyk, Christian Kozany, Bianca Sperl, Martin Gräber, Thorsten Berg
Publikováno v:
ACS chemical biology. 6(10)
Phosphorylation-dependent protein binding domains are crucially important for intracellular signaling pathways and thus highly relevant targets in chemical biology. By screening of chemical libraries against 12 structurally diverse phosphorylation-de