The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside.

Autor: Birkisdóttir, María B., van Galen, Ivar, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T., Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G., Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H. J., Dollé, Martijn E. T., Vermeij, Wilbert P.

Publikováno v: Frontiers in Aging; 10/12/2022, p1-12, 12p

The progeroid phenotype of Ku80 deficiency is dominant over DNA-PKCS deficiency

Autor: Reiling, Erwin, Dollé, Martijn E T, Youssef, Sameh A, Lee, Moonsook, Nagarajah, Bhawani, Roodbergen, Marianne, de With, Piet, de Bruin, Alain, Hoeijmakers, Jan H, Vijg, Jan, van Steeg, Harry, Hasty, Paul, LS Pathobiologie, PB TR, Tissue Repair

Publikováno v: PLoS One (print), 9(4). Public Library of Science
PLoS One, 9(4). Public Library of Science
PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e93568 (2014)

Ku80 and DNA-PKCS are both involved in the repair of double strand DNA breaks via the nonhomologous end joining (NHEJ) pathway. While ku80(-/-) mice exhibit a severely reduced lifespan and size, this phenotype is less pronounced in dna-pk(cs)(-/-) mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7afe7298300f6886725b18339703a43
https://doi.org/10.1371/journal.pone.0093568

The Progeroid Phenotype of Ku80 Deficiency Is Dominant over DNA-PKCS Deficiency.

Autor: Reiling, Erwin, Dollé, Martijn E. T., Youssef, Sameh A., Lee, Moonsook, Nagarajah, Bhawani, Roodbergen, Marianne, de With, Piet, de Bruin, Alain, Hoeijmakers, Jan H., Vijg, Jan, van Steeg, Harry, Hasty, Paul

Publikováno v: PLoS ONE; Apr2014, Vol. 9 Issue 4, p1-9, 9p

A New Rat Model of Otitis Media Caused byStreptococcus pneumoniae: Conditions and Application in Immunization Protocols

Autor: van der Ven, Leo T. M., van den Dobbelsteen, Germie P. J. M., Nagarajah, Bhawani, van Dijken, Harry, Dortant, Paul M., Vos, Josephus G., Roholl, Paul J. M.

Publikováno v: Infection and Immunity; November 1999, Vol. 67 Issue: 11 p6098-6103, 6p

Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness.

Autor: Pieren DKJ; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Smits NAM; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Imholz S; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Nagarajah B; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., van Oostrom CT; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Brandt RMC; Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands., Vermeij WP; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Dollé MET; Centre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands., Guichelaar T; Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.

Publikováno v: Frontiers in aging [Front Aging] 2021; Vol. 2. Date of Electronic Publication: 2021 May 11.