Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Nagaraj M. Kulkarni"'
Publikováno v:
ACS Omega, Vol 9, Iss 11, Pp 12611-12621 (2024)
Externí odkaz:
https://doaj.org/article/6533433ca3a8457d80819ada7dc1856f
Autor:
Mara Caputo, Emmelie Cansby, Sima Kumari, Yeshwant Kurhe, Syam Nair, Marcus Ståhlman, Nagaraj M. Kulkarni, Jan Borén, Hanns‐Ulrich Marschall, Matthias Blüher, Margit Mahlapuu
Publikováno v:
Hepatology Communications, Vol 5, Iss 7, Pp 1183-1200 (2021)
Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, primarily because of the massive global increase in obesity. Despite intense research efforts in this field, the factors that govern the initi
Externí odkaz:
https://doaj.org/article/4e024d45939a4d848075e192c67e1a5a
Autor:
Emmelie Cansby, Esther Nuñez-Durán, Elin Magnusson, Manoj Amrutkar, Sheri L. Booten, Nagaraj M. Kulkarni, L. Thomas Svensson, Jan Borén, Hanns-Ulrich Marschall, Mariam Aghajan, Margit Mahlapuu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 597-618 (2019)
Background & Aims: Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide. Currently, no specific pharmacologic therapy is available for NAFLD/NASH, which has been re
Externí odkaz:
https://doaj.org/article/9be6ef8a91c74cad8b389b66aebc0dd6
Autor:
Emmelie Cansby, Mara Caputo, Lei Gao, Nagaraj M. Kulkarni, Annika Nerstedt, Marcus Ståhlman, Jan Borén, Rando Porosk, Ursel Soomets, Matteo Pedrelli, Paolo Parini, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Margit Mahlapuu
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Externí odkaz:
https://doaj.org/article/76ee7c613d244adda29bbfe316fe4d15
Autor:
Ben Geoffrey A S, Nagaraj M Kulkarni, Deepak Agrawal, Nivedita Bharti, Rajappan Vetrivel, Kishan Gurram
Protein function modulation using small molecule binding is an important therapeutic strategy for many diseases. However, many proteins remain undruggable due to lack of suitable binding pockets for small molecule binding. Proximity induced protein d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4e4764b6d5c619ecfd9a3c97817daab
https://doi.org/10.1101/2022.10.04.510266
https://doi.org/10.1101/2022.10.04.510266
Proteolysis-Targeting Chimeric Molecules (PROTAC) is a rapidly emerging technology for drug target protein degradation and drugging undruggable drug targets. There is a growing literature on in-silico approaches to the complex problem of PROTAC desig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c14672fa738c238cb1d603b0771cf3b
https://doi.org/10.1101/2022.07.11.499663
https://doi.org/10.1101/2022.07.11.499663
Autor:
Ibrahim Abdullah, Sahara Juita Jamaluddin, Nagaraj M. Kulkarni, Rajan Ethiraj Ugandar, Kiran Chanabasappa Nilugal, Santosh Fattepur
Publikováno v:
British Food Journal. 122:3065-3075
PurposeOlanzapine is widely prescribed in the treatment of schizophrenia and various psychiatric illnesses. Schizophrenia patients have been reported to eat a diet that contain higher in fat and lower in fiber. High dietary fat intake can predispose
Autor:
Carina Sihlbom, Marcus Ståhlman, Margit Mahlapuu, Annika Nerstedt, Emmelie Cansby, Jan Borén, Hanns-Ulrich Marschall, Nagaraj M. Kulkarni, Elin Magnusson, Yeshwant Kurhe, Manoj Amrutkar, Matthias Blüher
Publikováno v:
The FASEB Journal. 33:9974-9989
Ectopic lipid storage in the liver is considered the main risk factor for nonalcoholic steatohepatitis (NASH). Understanding the molecular networks controlling hepatocellular lipid deposition is therefore essential for developing new strategies to ef
Autor:
Mara Caputo, Emmelie Cansby, Paolo Parini, Lei Gao, Matteo Pedrelli, Rando Porosk, Nagaraj M. Kulkarni, Jan Borén, Marcus Ståhlman, Ursel Soomets, Margit Mahlapuu, Hanns-Ulrich Marschall, Jenny Nyström, Brian W. Howell, Annika Nerstedt
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 24 (2020)
JCI Insight, Vol 5, Iss 24 (2020)
Diabetic kidney disease (DKD) is the most common cause of severe renal disease worldwide and the single strongest predictor of mortality in diabetes patients. Kidney steatosis has emerged as a critical trigger in the pathogenesis of DKD; however, the
Autor:
Sravan Kumar Reddy Theepireddy, Rathanakar Reddy Kura, Jayaprakash Narayan Kolla, Nagaraj M. Kulkarni
Publikováno v:
Herba Polonica, Vol 63, Iss 4, Pp 45-56 (2017)
SummaryAyurveda, whispered to be the ancient practice of healthcare existed and contributes a holistic approach to health, healing and longevity. Terminalia chebula Retz. is a popular plant and widely spread all over southern Asia. T. chebula is a na