Výsledky vyhledávání - "Nagaradona Harindranath"

The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus

Autor: Alfons Meindl, Frederick C. Mills, Nagaradona Harindranath, Edward E. Max, Mary Mitchell

Publikováno v: Gene. 221:215-224

Elk-1 is a transcription factor whose activation by several mitogen-activated protein kinases (MAPKs) mediates the immediate early responses of the c-fos promoter to growth factors and other stimuli. Here, we report the structure of the human elk-1 g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f94eeb953f6ac14d2f7d456e1f25de3f
https://doi.org/10.1016/s0378-1119(98)00448-x

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CD40 Ligand and Appropriate Cytokines Induce Switching to IgG, IgA, and IgE and Coordinated Germinal Center and Plasmacytoid Phenotypic Differentiation in a Human Monoclonal IgM+IgD+ B Cell Line

Autor: Andrea Cerutti, Hong Zan, Andras Schaffer, Leif Bergsagel, Nagaradona Harindranath, Edward E. Max, Paolo Casali

Publikováno v: The Journal of Immunology. 160:2145-2157

B lymphocytes are induced to undergo Ig class switching and a complex phenotypic differentiation by the milieu of the germinal center. Partly as a result of the lack of a suitable in vitro B cell model, the relationship between these processes in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::469cb13d9d41671c9e1afad28e23d70f
https://doi.org/10.4049/jimmunol.160.5.2145

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Enhancer Complexes Located Downstream of Both Human Immunoglobulin Cα Genes

Autor: Frederick C. Mills, Mary Mitchell, Edward E. Max, Nagaradona Harindranath

Publikováno v: The Journal of Experimental Medicine

To investigate regulation of human immunoglobulin heavy chain expression, we have cloned DNA downstream from the two human Calpha genes, corresponding to the position in the mouse IgH cluster of a locus control region (LCR) that includes an enhancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a90a6f39464b25e80dd4110247e68f
https://doi.org/10.1084/jem.186.6.845

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Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes

Autor: F. C. Mills, J M Bridon, Nagaradona Harindranath, Jacques Banchereau, E. E. Max, Hector Martinez-Valdez, Florence Malisan, Francine Brière

Publikováno v: The Journal of Experimental Medicine

Upon activation, B lymphocytes can change the isotype of the antibody they express by immunoglobulin (Ig) isotype switch recombination. In previous studies on the regulation of human IgG expression, we demonstrated that interleukin 10 (IL-10) could s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e0bb8ba703f108d8a6a3af8d21d411
http://europepmc.org/articles/PMC2192363

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Recombination activating genes-1 and -2 of the rabbit: Cloning and characterization of germline and expressed genes

Autor: Pushparani Dhanarajan, Wayne T. McCormack, Kenneth H. Roux, Nagaradona Harindranath, Rose G. Mage, Patrizia Fuschiotti

Publikováno v: Molecular Immunology. 30:1021-1032

The recombination activating genes RAG-1 and RAG-2 appear to be necessary components of the machinery needed for the Ig or TCR gene rearrangements that occur in developing B and T lymphocytes. In addition RAG-2 has been implicated in the process of V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03381f791068b60428de436497b926a
https://doi.org/10.1016/0161-5890(93)90127-w

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Evolutionarily conserved organization and sequences of germline diversity and joining regions of the rabbit T-cell receptor β2 chain

Autor: Cornelius B. Alexander, Rose G. Mage, Nagaradona Harindranath

Publikováno v: Molecular Immunology. 28:881-888

We previously reported that there are three different copies of T-cell receptor beta chain constant region (C beta) genes in some rabbits, two of which are present on an approximately 16-kb and one on an approximately 6-kb Eco RI fragment. We also re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cd8f693c9af571ef8112b4030405965
https://doi.org/10.1016/0161-5890(91)90052-l

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Complete sequence of the genes encoding the VH and VL regions of low- and high- affinity monoclonal lgM and lgA1 rheumatoid factors produced by CD5+ B cells from a rheumatoid arthritis patient

Autor: Abner Louis Notkins, Inna Goldfarb, Samuele E. Burastero, Paolo Casali, Nagaradona Harindranath, Hideyuki Ikematsu, Ronald L. Wilder

Publikováno v: International Immunology. 3:865-875

We have characterized the VH and VL genes of three low-affinity polyreactive and two high-affinity monoreactive IgM and IgA1 rheumatoid factor (RF) mAb generated using circulating CD5+ B cells from a single rheumatoid arthritis patient. We found that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cbe24da276b6a6c8fb4d45228ec2fa8
https://doi.org/10.1093/intimm/3.9.865

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Clonal analysis of a human antibody response. Quantitation of precursors of antibody-producing cells and generation and characterization of monoclonal IgM, IgG, and IgA to rabies virus

Autor: Inna Goldfarb, Paolo Casali, A. L. Notkins, Nagaradona Harindranath, Y. Ueki, M. Gore, H. Koprowski

Publikováno v: The Journal of Experimental Medicine
The Journal of experimental medicine, vol 171, iss 1

We quantitated and characterized the changes in the human B cell repertoire, at the clonal level, before and after immunization with rabies virus. Moreover, we generated 10 monoclonal cell lines producing IgM, IgG, and IgA antibodies to the virus. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d3d1f1181d894e98ae2081bce058039
https://doi.org/10.1084/jem.171.1.19

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