Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer’s disease

Autor: Preische, Oliver, Schultz, Stephanie A, Vöglein, Jonathan, Raichle, Marc, Ringman, John, Roh, Jee Hoon, Salloway, Stephen, Schofield, Peter, Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Levin, Johannes, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xiong, Chengjie, Xu, Xiong, Masters, Colin L, Martins, Ralph, Schofield, Peter R, Rossor, Martin N, Graff-Radford, Neill R, Ghetti, Bernardino, Ringman, John M, Apel, Anja, Noble, James M, Chhatwal, Jasmeer, Goate, Alison M, Benzinger, Tammie L S, Morris, John C, Bateman, Randall J, Wang, Guoqiao, Fagan, Anne M, McDade, Eric M, Gordon, Brian A, Kuhle, Jens, Jucker, Mathias, Network, Dominantly Inherited Alzheimer, Allegri, Ricardo, Amtashar, Fatima, Bateman, Randall, Benzinger, Tammie, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Kaeser, Stephan A, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chrem, Patricio, Chui, Helena, Cinco, Jake, Clifford, Jack, Cruchaga, Carlos, D'Mello, Mirelle, Barro, Christian, Donahue, Tamara, Douglas, Jane, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Gräber, Susanne, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Goate, Alison, Goldman, Jill, Gordon, Brian, Graff-Radford, Neill, Gray, Julia, Kuder-Buletta, Elke, Gurney, Jenny, Hassenstab, Jason, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, DiBari, Siri Houeland, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Karch, Celeste, la Fougère, Christian, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William, Koeppe, Robert, Lee, Jae-Hong, Marcus, Daniel, Mason, Neal Scott, Masters, Colin, Laske, Christoph, Maue-Dreyfus, Denise, McDade, Eric, Montoya, Lucy, Mori, Hiroshi, Morris, John, Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Norton, Joanne, Perrin, Richard

Publikováno v: Nature medicine, vol 25, iss 2
Nature medicine 25(2), 277-283 (2019). doi:10.1038/s41591-018-0304-3

Neurofilament light chain (NfL) is a promising fluid biomarker of disease progression for various cerebral proteopathies. Here we leverage the unique characteristics of the Dominantly Inherited Alzheimer Network and ultrasensitive immunoassay technol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b9fd3e17c1bfe604aea53e438c63ed
https://doi.org/10.1038/s41591-018-0304-3

Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease

Autor: Vermunt, Lisa, Dicks, Ellen, Wang, Guoqiao, Dincer, Aylin, Flores, Shaney, Keefe, Sarah J., Berman, Sarah B., Cash, David M., Chhatwal, Jasmeer P., Cruchaga, Carlos, Fox, Nick C., Ghetti, Bernardino, Graff-Radford, Neill R., Hassenstab, Jason, Karch, Celeste M., Laske, Christoph, Levin, Johannes, Masters, Colin L., McDade, Eric, Mori, Hiroshi, Morris, John C., Noble, James M., Perrin, Richard J., Schofield, Peter R., Xiong, Chengjie, Scheltens, Philip, Visser, Pieter Jelle, Bateman, Randall J., Benzinger, Tammie L. S., Tijms, Betty M., Gordon, Brian A., Allegri, Ricardo, Amtashar, Fatima, Berman, Sarah, Bodge, Courtney, Brandon, Susan, Brooks, William, Buck, Jill, Buckles, Virginia, Chea, Sochenda, Chrem, Patricio, Chui, Helena, Cinco, Jake, Jack, Clifford, D'Mello, Mirelle, Donahue, Tamara, Douglas, Jane, Edigo, Noelia, Erekin-Taner, Nilufer, Fagan, Anne, Farlow, Marty, Farrar, Angela, Feldman, Howard, Flynn, Gigi, Fox, Nick, Franklin, Erin, Fujii, Hisako, Gant, Cortaiga, Gardener, Samantha, Goate, Alison, Goldman, Jill, Gordon, Brian, Gray, Julia, Gurney, Jenny, Hirohara, Mie, Holtzman, David, Hornbeck, Russ, Dibari, Siri Houeland, Ikeuchi, Takeshi, Ikonomovic, Snezana, Jerome, Gina, Jucker, Mathias, Kasuga, Kensaku, Kawarabayashi, Takeshi, Klunk, William, Koeppe, Robert, Kuder-Buletta, Elke, Marcus, Daniel, Martins, Ralph, Mason, Neal Scott, Maue-Dreyfus, Denise, Montoya, Lucy, Nagamatsu, Akem, Neimeyer, Katie, Noble, James, Norton, Joanne, Perrin, Richard, Raichle, Marc, Ringman, John, Roh, Jee Hoon, Schofield, Peter, Shimada, Hiroyuki, Shiroto, Tomoyo, Shoji, Mikio, Sigurdson, Wendy, Sohrabi, Hamid, Sparks, Paige, Suzuki, Kazushi, Swisher, Laura, Taddei, Kevin, Wang, Jen, Wang, Peter, Weiner, Mike, Wolfsberger, Mary, Xu, Xiong

Publikováno v: Brain Communications
Vermunt, L, Dicks, E, Wang, G, Dincer, A, Flores, S, Keefe, S J, Berman, S B, Cash, D M, Chhatwal, J P, Cruchaga, C, Fox, N C, Ghetti, B, Graff-Radford, N R, Hassenstab, J, Karch, C M, Laske, C, Levin, J, Masters, C L, McDade, E, Mori, H, Morris, J C, Noble, J M, Perrin, R J, Schofield, P R, Xiong, C, Scheltens, P, Visser, P J, Bateman, R J, Benzinger, T L S, Tijms, B M, Gordon, B A, Allegri, R, Amtashar, F, Berman, S, Bodge, C, Brandon, S, Brooks, W, Buck, J, Buckles, V, Chea, S, Chrem, P, Chui, H, Cinco, J, Jack, C, D'Mello, M, Donahue, T, Douglas, J, Edigo, N, Erekin-Taner, N, Fagan, A, Farlow, M, Farrar, A, Feldman, H, Flynn, G, Fox, N, Franklin, E, Fujii, H, Gant, C, Gardener, S, Ghetti, B, Goate, A, Goldman, J, Gordon, B, Gray, J, Gurney, J, Hassenstab, J, Hirohara, M, Holtzman, D, Hornbeck, R, Dibari, S H, Ikeuchi, T, Ikonomovic, S, Jerome, G, Jucker, M, Kasuga, K, Kawarabayashi, T, Klunk, W, Koeppe, R, Kuder-Buletta, E, Laske, C, Levin, J, Marcus, D, Martins, R, Mason, N S, Maue-Dreyfus, D, McDade, E, Montoya, L, Mori, H, Nagamatsu, A, Neimeyer, K, Noble, J, Norton, J, Perrin, R, Raichle, M, Ringman, J, Roh, J H, Schofield, P, Shimada, H, Shiroto, T, Shoji, M, Sigurdson, W, Sohrabi, H, Sparks, P, Suzuki, K, Swisher, L, Taddei, K, Wang, J, Wang, P, Weiner, M, Wolfsberger, M, Xiong, C & Xu, X 2020, ' Single-subject grey matter network trajectories over the disease course of autosomal dominant Alzheimer's disease ', Brain Communications, vol. 2, no. 2, fcaa102, pp. fcaa102 . https://doi.org/10.1093/braincomms/fcaa102, https://doi.org/10.1093/braincomms/fcaa102
Brain Communications, 2(2):fcaa102. Oxford University Press
Brain Communications, 2(2):102. Oxford University Press
Brain communications 2(2), fcaa102 (2020). doi:10.1093/braincomms/fcaa102

Structural grey matter covariance networks provide an individual quantification of morphological patterns in the brain. The network integrity is disrupted in sporadic Alzheimer’s disease, and network properties show associations with the level of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2883d1aaa6325039e2609ecda6d27a79
https://pubmed.ncbi.nlm.nih.gov/33225274