Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Nagahisa Yamaoka"'
Autor:
Tetsuo Nakabayashi, Akihisa Maeda, Takashi Dan, Kenji Murano, Nagahisa Yamaoka, Toshio Miyata, Hidehiko Kodama, Kanji Meguro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:809-813
Novel plasminogen activator inhibitor-1 (PAI-1) inhibitors with highly improved oral bioavailability were discovered by structure-activity relationship studies on N-acyl-5-chloroanthranilic acid derivatives. Because lipophilic N-acyl groups seemed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3839236b25a26fdf28dc0b6693b114bb
https://doi.org/10.1016/j.bmcl.2017.11.016
https://doi.org/10.1016/j.bmcl.2017.11.016
Publikováno v:
Tetrahedron Letters. 36:7251-7254
Chiral enamines, imines, and hydrazones bearing phosphine groups at the chiral centers and allylic parts at the appropriate positions underwent intramolecular asymmetric carbon-carbon bond formations in the palladium-catalyzed reactions to give optic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ecd395334b95650d3ac761e8e18da7a
https://doi.org/10.1016/0040-4039(95)01502-9
https://doi.org/10.1016/0040-4039(95)01502-9
Publikováno v:
ChemInform. 41
It is shown that compounds possessing bulky or/and hydrophobic substituents on both the thiophene rings exhibit potent PAI-1 inhibitory activities irrespective of the positions of the substituents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::595e9e7a5d673c595dd95e7ca0a09423
https://doi.org/10.1002/chin.201043103
https://doi.org/10.1002/chin.201043103
Publikováno v:
ChemInform. 27
Chiral enamines, imines, and hydrazones bearing phosphine groups at the chiral centers and allylic parts at the appropriate positions underwent intramolecular asymmetric carbon-carbon bond formations in the palladium-catalyzed reactions to give optic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b1c4a85a1723eb547d2b27b88490de
https://doi.org/10.1002/chin.199603083
https://doi.org/10.1002/chin.199603083
Autor:
Nagahisa Yamaoka, Takashi Dan, Kanji Meguro, Hidehiko Kodama, Shunya Takizawa, Noriaki Hirayama, Charles van Ypersele de Strihou, Yuko Izuhara, Toshio Miyata
Publikováno v:
Journal of Cerebral Blood Flow and Metabolism, Vol. 30, no. 5, p. 904-912 (2010)
Inhibition of plasminogen activator inhibitor (PAI)-1 is useful to treat several disorders including thrombosis. An inhibitor of PAI-1 (TM5275) was newly identified by an extensive study of structure-activity relationship based on a lead compound (TM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7123760a15cbac5b7d7c6c338827a892
https://hdl.handle.net/2078.1/33912
https://hdl.handle.net/2078.1/33912
