Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Nagahiro Minato"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102472- (2023)
Summary: Senescence-associated (SA) CD4+ T cells, which increase with age, may underlie the development of autoimmunity and chronic inflammation, but their pathological function remains understudied. Here, we present a protocol to isolate CD153+ SA-T
Externí odkaz:
https://doaj.org/article/7633d2857bea46cea57cf86b577879c4
Autor:
Yuki Sato, Akiko Oguchi, Yuji Fukushima, Kyoko Masuda, Naoya Toriu, Keisuke Taniguchi, Takahisa Yoshikawa, Xiaotong Cui, Makiko Kondo, Takeshi Hosoi, Shota Komidori, Yoko Shimizu, Harumi Fujita, Li Jiang, Yingyi Kong, Takashi Yamanashi, Jun Seita, Takuya Yamamoto, Shinya Toyokuni, Yoko Hamazaki, Masakazu Hattori, Yasunobu Yoshikai, Peter Boor, Jürgen Floege, Hiroshi Kawamoto, Yasuhiro Murakawa, Nagahiro Minato, Motoko Yanagita
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Tertiary lymphoid tissues (TLTs) facilitate local T and B cell interactions in chronically inflamed organs. However, the cells and molecular pathways that govern TLT formation are poorly defined. Here, we identified TNF superfamily CD153/CD30 signali
Externí odkaz:
https://doaj.org/article/4e3ce5bb02bd4250838868a6955a71d3
Publikováno v:
Inflammation and Regeneration, Vol 38, Iss 1, Pp 1-6 (2018)
Abstract Immunosenescence is age-associated changes in the immunological functions, including diminished acquired immunity against infection, pro-inflammatory traits, and increased risk of autoimmunity. The proportions of memory-phenotype T cells in
Externí odkaz:
https://doaj.org/article/3a4966b6f3bc47baac98f88217028090
Autor:
Ning Wang, Jun Weng, Jing Xia, Yangjin Zhu, Qiongrong Chen, Die Hu, Xue Zhang, Rui Sun, Jueping Feng, Nagahiro Minato, Yiping Gong, Li Su
Publikováno v:
Stem Cell Research, Vol 49, Iss , Pp 102099- (2020)
SIPA1, a GTPase activating protein that negatively regulates Ras-related protein (Rap), is a potential modulator of tumor metastasis and recurrence. In this study, we first showed that SIPA1 facilitated the stemness features of breast cancer cells, s
Externí odkaz:
https://doaj.org/article/a6cab45997a44675b4c154ee18ed7321
Autor:
Pingnan Xiao, Monika Dolinska, Lakshmi Sandhow, Makoto Kondo, Anne-Sofie Johansson, Thibault Bouderlique, Ying Zhao, Xidan Li, Marios Dimitriou, George Z. Rassidakis, Eva Hellström-Lindberg, Nagahiro Minato, Julian Walfridsson, David T. Scadden, Mikael Sigvardsson, Hong Qian
Publikováno v:
Blood Advances, Vol 2, Iss 5, Pp 534-548 (2018)
Abstract: Mutations of signal-induced proliferation-associated gene 1 (SIPA1), a RAP1 GTPase-activating protein, were reported in patients with juvenile myelomonocytic leukemia, a childhood myelodysplastic/myeloproliferative neoplasm (MDS/MPN). Sipa1
Externí odkaz:
https://doaj.org/article/9062250244da4e5ca36413d3405d4e8e
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Chronic myelogenous leukemia (CML)-initiating cells are resistant to kinase inhibitors. Here the authors show that deficiency of the Rap1 GTPase-activating protein Sipa1 in the tumor microenvironment releases an immune response that eradicates CML-in
Externí odkaz:
https://doaj.org/article/5257dd023ec6425cad3f0923e8fae487
Autor:
Yoshimasa Tanaka, Masashi Iwasaki, Kaoru Murata-Hirai, Kenji Matsumoto, Kosuke Hayashi, Haruki Okamura, Tomoharu Sugie, Nagahiro Minato, Craig T. Morita, Masakazu Toi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Bisphosphonates have benefits in breast cancer and multiple myeloma patients and have been used with adoptive immunotherapy with γδ T cells expressing Vγ2 Vδ2 TCRs. Although treatment with γδ T cells is safe, it has shown limited effic
Externí odkaz:
https://doaj.org/article/9f0bf342bae840ad95d227a5c3a671ad
Autor:
Ali Nazmi, Kristen L Hoek, Michael J Greer, Maria B Piazuelo, Nagahiro Minato, Danyvid Olivares-Villagómez
Publikováno v:
PLoS ONE, Vol 14, Iss 7, p e0215883 (2019)
Innate CD8αα+ cells, also referred to as iCD8α cells, are TCR-negative intraepithelial lymphocytes (IEL) possessing cytokine and chemokine profiles and functions related to innate immune cells. iCD8α cells constitute an important source of osteop
Externí odkaz:
https://doaj.org/article/1471e24af1e14c128bbdf5e8eed8db8b
Autor:
Izumi Ohigashi, Saulius Zuklys, Mie Sakata, Carlos E. Mayer, Yoko Hamazaki, Nagahiro Minato, Georg A. Hollander, Yousuke Takahama
Publikováno v:
Cell Reports, Vol 13, Iss 7, Pp 1432-1443 (2015)
Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also ha
Externí odkaz:
https://doaj.org/article/c52024c5b38643ecab82ba32ba1d7864
Autor:
Sooghee Chang, Youn-Hee Kim, Young-Joo Kim, Young-Woo Kim, Sungyoon Moon, Yong Yook Lee, Jin Sun Jung, Youngsoo Kim, Hi-Eun Jung, Tae-Joo Kim, Taek-Chin Cheong, Hye-Jung Moon, Jung-Ah Cho, Hang-Rae Kim, Dohyun Han, Yirang Na, Seung-Hyeok Seok, Nam-Hyuk Cho, Hai-Chon Lee, Eun-Hee Nam, Hyosuk Cho, Murim Choi, Nagahiro Minato, Seung-Yong Seong
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Bile acids (BAs) control metabolism and inflammation by interacting with several receptors. Here, we report that intravenous infusion of taurodeoxycholate (TDCA) decreases serum pro-inflammatory cytokines, normalizes hypotension, protects against ren
Externí odkaz:
https://doaj.org/article/58787300b827444c9af4af7cbc772af3