Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Nagaaki Sato"'
Autor:
Aiko Masuko, Yoshihisa Shirasaki, Kanako Iwakiri, Nagaaki Sato, Akiko Nozoe, Tsuyoshi Busujima, Kiyokazu Kitano, Eiji Munetomo, Hiroaki Tanaka, Fusayo Io, Masako Saito, Shunsuke Kamigaso, Kato Koji
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:228-238
We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76e1450019fccf9e436fe7d25935aaab
https://doi.org/10.1248/cpb.c15-00803
https://doi.org/10.1248/cpb.c15-00803
Autor:
Yoshihisa Shirasaki, Eiji Munetomo, Naoto Osaki, Kiyokazu Kitano, Hiroaki Tanaka, Nagaaki Sato, Toshiya Minagawa, Tsuyoshi Busujima, Masako Saito, Koji Yoshida
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:5922-5931
MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1c84a9e33d5c1786857b189b8529cb
https://doi.org/10.1016/j.bmc.2015.06.065
https://doi.org/10.1016/j.bmc.2015.06.065
Publikováno v:
Fisheries Science. 79:767-777
This report first describes the morphological and habitat characteristics of larval and juvenile Roughscale Sole Clidoderma asperrimum. Five metamorphosing larvae (22.1–31.7 mm standard length, SL) and 12 juveniles (23.7–46.4 mm SL) were collecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa89a583f460d91df97dcdab6bbd5cd5
https://doi.org/10.1007/s12562-013-0649-y
https://doi.org/10.1007/s12562-013-0649-y
Autor:
Tsuyoshi, Busujima, Hiroaki, Tanaka, Kanako, Iwakiri, Yoshihisa, Shirasaki, Eiji, Munetomo, Masako, Saito, Aiko, Masuko, Kiyokazu, Kitano, Fusayo, Io, Koji, Kato, Shunsuke, Kamigaso, Akiko, Nozoe, Nagaaki, Sato
Publikováno v:
Chemicalpharmaceutical bulletin. 64(3)
We previously reported 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide 2 as on orally available monoacylglycerol acyltransferase 2 (MGAT2) inhibitor which exhibited an in vivo efficacy at an oral dose o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4daba8aa320dfe9e522f08c800275b3
https://pubmed.ncbi.nlm.nih.gov/26936050
https://pubmed.ncbi.nlm.nih.gov/26936050
Autor:
John J. Renger, John Palcza, Nagaaki Sato, Robert Iannone, A Buntinx, B R Bloem, R H Hargreaves, Rik C. Schoemaker, K S Koblan, Laura B. Rosen, Adam F. Cohen, J.M.A. van Gerven, Chodakewitz Jeffrey A, Keith Gottesdiener, Remco W. M. Zoethout, Sabrina Marsilio, Shigeru Tokita, Gail Murphy, K Van Dyck, E D Louis
Publikováno v:
Journal of Psychopharmacology, 26, 2, pp. 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302
Journal of Psychopharmacology, 26(2), 292-302
Journal of Psychopharmacology, 26, 292-302
Item does not contain fulltext Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the pathological processes involved in the generation of ET. Histamine-3 receptor inverse agonists (H3RIA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de1fbad04db88a008450901c8347b622
https://hdl.handle.net/2066/109808
https://hdl.handle.net/2066/109808
Autor:
H Matsushita, Makoto Ito, H Iwaasa, Akio Kanatani, Masahiko Ito, Akane Ishihara, Joseph M. Metzger, Donald J. Marsh, Akira Gomori, Yuji Haga, M Moriya, S Tokita, N Takenaga, Nagaaki Sato, Douglas J. MacNeil
Publikováno v:
British Journal of Pharmacology. 159:374-383
Background and purpose: Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide expressed in the lateral hypothalamus that is involved in feeding and body weight regulation. Intracerebroventricular infusion of a peptidic MCH1 receptor antag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57ca982cfee114cae2a44d78ff4fd97c
https://doi.org/10.1111/j.1476-5381.2009.00536.x
https://doi.org/10.1111/j.1476-5381.2009.00536.x
Autor:
Akane Ishihara, Shigeru Tokita, Satoru Ito, Hiroshi Miyazoe, Masahiko Ito, Minoru Moriya, Kazuho Nakase, Kaori Kamijo, Hiroko Matsushita, Minoru Kameda, Kouta Masutani, Etsuko Sekino, Akihiro Takezawa, Norihiro Takenaga, Takehiro Fukami, Akio Kanatani, Nagaaki Sato, Makoto Ando, Junko Ito, Takao Suzuki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5339-5345
Optimization of the lead 2a led to the identification of a novel diarylketoxime class of melanin-concentrating hormone 1 receptor (MCH-1R) antagonists. Our focus was directed toward improvement of hERG activity and metabolic stability. The representa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d7fb37b33c5d2a3dbe6fc37052a6d
https://doi.org/10.1016/j.bmcl.2009.07.132
https://doi.org/10.1016/j.bmcl.2009.07.132
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4075-4078
Radioligands are powerful tools for examining the pharmacological profiles of chemical leads and thus facilitate drug discovery. In this study, we identified and characterized 3-([1,1,1-(3)H]methyl)-2-(4-{[3-(1-pyrrolidinyl)propyl]oxy} phenyl)-4(3H)-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a07cb8a22d75cadd4a421a02bf54476
https://doi.org/10.1016/j.bmcl.2009.06.025
https://doi.org/10.1016/j.bmcl.2009.06.025
Autor:
Toshiyuki Takahashi, Shigeru Tokita, Nagaaki Sato, Takashi Mizutani, Tsuyoshi Nagase, Maki Kanesaka, Takahide Sasaki, Norihiro Takenaga, Ryo Yoshimoto, Yuko Mitobe, Sayaka Ito, Takeshi Tanaka, Yasuhisa Miyamoto
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:4232-4236
A series of novel dihydrobenzoxathiin derivatives was synthesized and evaluated as potent human histamine H3 receptor inverse agonists. After systematic modification of lead 1a, the potent and selective histamine H3 inverse agonist 1-(3-{4-[(2S,3S)-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97a46737c17f95d721cb873a818e2822
https://doi.org/10.1016/j.bmcl.2009.05.101
https://doi.org/10.1016/j.bmcl.2009.05.101
Autor:
Ken Shimamura, Katsumi Aragane, Toshiyuki Takahashi, Maki Kanesaka, Yasuhisa Miyamoto, Shigeru Tokita, Takahide Sasaki, Tsuyoshi Nagase, Ryo Yoshimoto, Hidefumi Kitazawa, Nagaaki Sato, Akira Nagumo
Publikováno v:
Journal of Medicinal Chemistry. 52:4111-4114
Long chain fatty acid elongase 6 (ELOVL6) catalyzes the elongation of long chain fatty acyl-CoAs and is a potential target for the treatment of metabolic disorders. The ultrahigh throughput screen of our corporate chemical collections resulted in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0464844a9a0dc51ceb1eda04f4e37e2b
https://doi.org/10.1021/jm900488k
https://doi.org/10.1021/jm900488k