Zobrazeno 1 - 10
of 17
pro vyhledávání: '"NagaRekha Pasupuleti"'
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e63038 (2013)
Amiloride is a potassium-sparing diuretic that has been used as an anti-kaliuretic for the chronic management of hypertension and heart failure. Several studies have identified a potential anti-cancer role for amiloride, however the mechanisms underl
Externí odkaz:
https://doaj.org/article/bda99a8771f14751ace52d44410d76b1
Autor:
Ram H Nagaraj, Alok Kumar Panda, Shilpa Shanthakumar, Puttur Santhoshkumar, NagaRekha Pasupuleti, Benlian Wang, Ashis Biswas
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30257 (2012)
Methylglyoxal (MGO) is an α-dicarbonyl compound present ubiquitously in the human body. MGO reacts with arginine residues in proteins and forms adducts such as hydroimidazolone and argpyrimidine in vivo. Previously, we showed that MGO-mediated modif
Externí odkaz:
https://doaj.org/article/2435bbd880f34e0daada30c99aa26019
Publikováno v:
Anti-cancer agents in medicinal chemistry. 17(1)
High grade gliomas (HGGs) are primary CNS cancers with more than 95% of patients experiencing tumor recurrence following radiation therapy, chemotherapy, and/or an anti-angiogenic therapy. Populations of glioma ‘stem-like’ cells (GSCs) exist in b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e60e71aaf28afb8d0ecf8e6580b552
https://pubmed.ncbi.nlm.nih.gov/27357540
https://pubmed.ncbi.nlm.nih.gov/27357540
Autor:
Grace K. Pavlath, Amena Saleh, Ramkumar Sambasivan, Nagarekha Pasupuleti, Sirisha Cheedipudi, Jyotsna Dhawan
Publikováno v:
Journal of Cell Science. 122:3481-3491
Quiescent muscle progenitors called satellite cells persist in adult skeletal muscle and, upon injury to muscle, re-enter the cell cycle and either undergo self-renewal or differentiate to regenerate lost myofibers. Using synchronized cultures of C2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bfbcb4e0dcc962b2fe334bc9de9b5b
https://doi.org/10.1242/jcs.048678
https://doi.org/10.1242/jcs.048678
Autor:
Dinesh Mahajan, Anthony Valenzuela, Yamini Manohar, Sundeep Dugar, Nagarekha Pasupuleti, Jann N. Sarkaria, Fredric A Gorin
High grade gliomas (HGGs) are lethal brain cancers, accounting for 78% of adult onset primary CNS malignancies. HGGs are resistant to current conventional therapies, including radiation therapy (RT), chemotherapy, and treatment with anti-angiogenic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26db89f678364062d68d2d7e7057da3e
https://europepmc.org/articles/PMC4638484/
https://europepmc.org/articles/PMC4638484/
Mis-trafficking of endosomal urokinase proteins triggers drug-induced glioma nonapoptotic cell death
Publikováno v:
Molecular pharmacology, vol 87, iss 4
5-Benzylglycinyl-amiloride (UCD38B) is the parent molecule of a class of anticancer small molecules that kill proliferative and nonproliferative high-grade glioma cells by programmed necrosis. UCD38B intracellularly triggers endocytosis, causing 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0674098cf5709f45f13662390ebb7d45
https://escholarship.org/uc/item/3k98r88h
https://escholarship.org/uc/item/3k98r88h
Autor:
Nagarekha Pasupuleti, Ana Cristina Grodzki, Pamela J. Lein, Fredric A Gorin, Michael H. Nantz, Bhaskar Poola
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 352(3)
Neuropathic pain is a maladaptive immune response to peripheral nerve injury that causes a chronic painful condition refractory to most analgesics. Nitric oxide (NO), which is produced by nitric oxide synthases (NOSs), has been implicated as a key fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1495134c93a781c71e6a30386b9dde
https://pubmed.ncbi.nlm.nih.gov/25538105
https://pubmed.ncbi.nlm.nih.gov/25538105
5′–Βenzylglycinyl-amiloride (UCD38B) and glycinyl-amiloride (UCD74A) are cell-permeant and cell-impermeant derivatives of amiloride, respectively, and used here to identify the cellular mechanisms of action underlying their antiglioma effects. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7415449df40fa62f76c498afa9f29992
https://europepmc.org/articles/PMC3583503/
https://europepmc.org/articles/PMC3583503/
The relative non-toxicity of the diuretic amiloride, coupled with its selective inhibition of the protease urokinase plasminogen activator (uPA), makes this compound class attractive for structure-activity studies. Herein we substituted the C(2)-acyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33f4b0ac88b9331acd3667f5bd5d29c
https://europepmc.org/articles/PMC3329872/
https://europepmc.org/articles/PMC3329872/
Autor:
Mikhail Linetsky, Nagarekha Pasupuleti, Rooban B. Nahomi, Alok Kumar Panda, Ashis Biswas, Smitha Padmanabha, Puttur Santhoshkumar, Ram H. Nagaraj, Shilpa Shanthakumar, Benlian Wang
Publikováno v:
Biochimica et biophysica acta. 1822(2)
α-Crystallin is a major protein in the human lens that is perceived to help to maintain the transparency of the lens through its chaperone function. In this study, we demonstrate that many lens proteins including αA-crystallin are acetylated in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778087994999eb3cb9c65dfff04a898a
https://pubmed.ncbi.nlm.nih.gov/22120592
https://pubmed.ncbi.nlm.nih.gov/22120592