Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Naga Suresh Adapala"'
Autor:
Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai, Muhammad Farooq Rai, Srikanth Singamaneni, Gabriel Mbalaviele, Robert Brophy, Yousef Abu-Amer
Publikováno v:
eLife, Vol 11 (2022)
Osteoarthritis is the most common joint disease in the world with significant societal consequences but lacks effective disease-modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be targeted to preven
Externí odkaz:
https://doaj.org/article/f9c57b6e795848f5bbf6bb68c37c646d
Autor:
Naga Suresh Adapala, Gaurav Swarnkar, Manoj Arra, Jie Shen, Gabriel Mbalaviele, Ke Ke, Yousef Abu-Amer
Publikováno v:
eLife, Vol 9 (2020)
Inflammatory osteolysis is governed by exacerbated osteoclastogenesis. Ample evidence points to central role of NF-κB in such pathologic responses, yet the precise mechanisms underpinning specificity of these responses remain unclear. We propose tha
Externí odkaz:
https://doaj.org/article/792a33009af54accac823fe33973b38b
Publikováno v:
Bone Reports, Vol 10, Iss , Pp - (2019)
Our previous studies showed that in a mouse model in which PI3K-AKT activation was increased (YF mice), osteoclast numbers and levels of SDF-1, a chemokine, were augmented. The purpose of this study was to delineate the role of PI3K activation in reg
Externí odkaz:
https://doaj.org/article/dec485a01f5f4b86bd4a2ba118ff7c29
Autor:
Naga Suresh Adapala, Harry K W Kim
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153174 (2016)
OBJECTIVE:Ischemic osteonecrosis of the femoral head (ONFH) in piglets results in an ischemic injury to the immature articular cartilage. The molecular changes in the articular cartilage in response to ONFH have not been investigated using a transcri
Externí odkaz:
https://doaj.org/article/803b77f9af284235be9542a45de009e3
Autor:
Vanessa Scanlon, Do Yu Soung, Naga Suresh Adapala, Elise Morgan, Marc F Hansen, Hicham Drissi, Archana Sanjay
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138194 (2015)
Mice in which Cbl is unable to bind PI3K (YF mice) display increased bone volume due to enhanced bone formation and repressed bone resorption during normal bone homeostasis. We investigated the effects of disrupted Cbl-PI3K interaction on fracture he
Externí odkaz:
https://doaj.org/article/73f71ab2ae8e4d8dafaf09d2c2491d1c
Autor:
Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai, Muhammad Farooq Rai, Srikanth Singamaneni, Gabriel Mbalaviele, Robert Brophy, Yousef Abu-Amer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38671469a59a56478ef4076f4b75b729
https://doi.org/10.7554/elife.80725.sa2
https://doi.org/10.7554/elife.80725.sa2
Publikováno v:
Bone
Effective bone resorption by osteoclasts is critical for balanced bone remodeling. We have previously reported that mice harboring a substitution mutation of tyrosine 737 to phenylalanine in the adapter protein Cbl (Cbl Y737F , YF) have increased bon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b35b5e5d59917dd18b8f800441922
https://doi.org/10.1016/j.bone.2019.07.009
https://doi.org/10.1016/j.bone.2019.07.009
Autor:
null Yinshi Ren, null Zhuo Deng, null Vishal Gokani, null Michael Kutschke, null Thomas Wesley Mitchell, null Olumide Aruwajoye, null Naga Suresh Adapala, null Nobuhiro Kamiya, null Yousef Abu‐Amer, null Harry K.W. Kim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd40aef21c34a7a1406b644d4864ca3
https://doi.org/10.1002/jbmr.4191/v3/response1
https://doi.org/10.1002/jbmr.4191/v3/response1
Autor:
Thomas Mitchell, Harry K.W. Kim, Zhuo Deng, Yinshi Ren, Nobuhiro Kamiya, Naga Suresh Adapala, Vishal Gokani, Michael Kutschke, Yousef Abu-Amer, Olumide Aruwajoye
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral ResearchReferences. 36(2)
Legg-Calve-Perthes disease (LCPD) is a juvenile form of ischemic femoral head osteonecrosis, which produces chronic hip synovitis, permanent femoral head deformity, and premature osteoarthritis. Currently, there is no medical therapy for LCPD. Interl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf0926eef363c2d622db89f6df96012
https://pubmed.ncbi.nlm.nih.gov/33053220
https://pubmed.ncbi.nlm.nih.gov/33053220