Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Naga Kiran Duggirala"'
Publikováno v:
Molecular pharmaceutics. 19(7)
Drugs containing an amino aromatic nitrogen moiety were stabilized in the amorphous form by the surfactant cholic acid (CA). Coamorphous systems of lamotrigine (LAM), pyrimethamine (PYR), and trimethoprim (TRI) were each prepared with CA. Drug-CA int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7f989c3a99c2d5f1f9ecf61cd6a768a
https://pubmed.ncbi.nlm.nih.gov/35687125
https://pubmed.ncbi.nlm.nih.gov/35687125
Autor:
Michael J. Zaworotko, Shawn M. LaCasse, Joseph F. Krzyzaniak, Kapildev K. Arora, Naga Kiran Duggirala
Publikováno v:
Crystal Growth & Design. 20:617-626
Phase transformation of an active pharmaceutical ingredient in the solid state can influence the physicochemical properties and consequently drug product performance. The neat cocrystal of Ertuglif...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efc984c270006db1c5dee5500ba64726
https://doi.org/10.1021/acs.cgd.9b00946
https://doi.org/10.1021/acs.cgd.9b00946
Publikováno v:
Molecular Pharmaceutics. 17:274-283
Formulation of a cocrystal into a solid pharmaceutical dosage form entails numerous processing steps during which there is risk of dissociation. In an effort to reduce the number of unit operations, we have attempted the in situ formation of an indom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6fbb36e4f669f71ded0b18ca9c548d
https://doi.org/10.1021/acs.molpharmaceut.9b01004
https://doi.org/10.1021/acs.molpharmaceut.9b01004
Publikováno v:
Chemical Communications. 55:5551-5554
A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df26c691b4cd01415a93933564df88b
https://doi.org/10.1039/c9cc02021g
https://doi.org/10.1039/c9cc02021g
Publikováno v:
Chemical Communications. 52:640-655
Cocrystals, a long known but understudied class of crystalline solids, have attracted interest from crystal engineers and pharmaceutical scientists in the past decade and are now an integral part of the preformulation stage of drug development. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26f71be4bd588db79aee7df1e39217e9
https://doi.org/10.1039/c5cc08216a
https://doi.org/10.1039/c5cc08216a
Autor:
Kapildev K. Arora, Naga Kiran Duggirala, Zhaohui Lei, Michael J. Zaworotko, Joseph F. Krzyzaniak, Heather Frericks Schmidt
Publikováno v:
Molecular pharmaceutics. 15(5)
The current study integrates formation enthalpy and traditional slurry experiments to quickly assess the physical stability of cocrystal drug substance candidates for their potential to support drug development. Cocrystals of an antidiabetic drug (GK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3c9a278cf6e230fedb495a7c3e9dbc
https://pubmed.ncbi.nlm.nih.gov/29659293
https://pubmed.ncbi.nlm.nih.gov/29659293
Autor:
Łukasz Wojtas, Naga Kiran Duggirala, Michael J. Zaworotko, Geoffrey P. F. Wood, Miranda L. Perry, Addison Fischer
Publikováno v:
Crystal Growth & Design. 15:4341-4354
Crystal engineering strategies have been delineated during the past decade for the design of multi-component molecular crystals (molecular cocrystals, MCCs). However, the same depth of understanding has not yet been established for cocrystals that ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94fd90aa652107f9732816937d7712b4
https://doi.org/10.1021/acs.cgd.5b00628
https://doi.org/10.1021/acs.cgd.5b00628
Autor:
Amber Vyas, Raj Suryanarayanan, Joseph F. Krzyzaniak, Naga Kiran Duggirala, Kapildev K. Arora
Publikováno v:
Molecular pharmaceutics. 14(11)
Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated in the presence of numerous pharmaceutical excipients. In cocrystal–excipient binary systems, the water mediated dissociation reaction occurred under ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ba2a30365b217f9e3c1daf7e6e5791e
https://pubmed.ncbi.nlm.nih.gov/28990387
https://pubmed.ncbi.nlm.nih.gov/28990387
Publikováno v:
Crystal Growth & Design. 14:6135-6142
Current lithium drugs are plagued with a narrow therapeutic window and tend to be hygroscopic. However, they remain the gold standard for treating manic episodes in bipolar disorder. In this contribution, we report a crystal engineering study aimed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01df9ef647541588c3e8d31dde5df275
https://doi.org/10.1021/cg501310d
https://doi.org/10.1021/cg501310d
Autor:
Brian Giunta, Lukasz Wojtas, Naga Kiran Duggirala, R. Douglas Shytle, Jared Ehrhart, Michael J. Zaworotko, Seol-Hee Kim, Adam J. Smith, Jingji Jin, Jun Tan
Publikováno v:
Molecular Pharmaceutics
Current United States Food and Drug Administration (FDA)-approved lithium salts are plagued with a narrow therapeutic window. Recent attempts to find alternative drugs have identified new chemical entities, but lithium's polypharmacological mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e76b76de9239cefb25bc1ddf7586729
https://doi.org/10.1021/mp400571a
https://doi.org/10.1021/mp400571a