Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Autor: Jerry H. Houl, Zu Ye, Chris A. Brosey, Lakshitha P. F. Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L. Walker, Yasin Pourfarjam, Leslie S. Warden, Naga Babu Chinnam, Davide Moiani, Roderick A. Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D. Nagel, Tom Ellenberger, In-Kwon Kim, Darin E. Jones, Zamal Ahmed, John A. Tainer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG in

Externí odkaz: https://doaj.org/article/b8239efdcde244de83ae43188c91b2d3

Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights

Autor: Naga Babu Chinnam, Aleem Syed, Kathryn H. Burnett, Greg L. Hura, John A. Tainer, Susan E. Tsutakawa

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071620625

Structures provide a critical breakthrough step for biological analyses, and Small Angle X-ray Scattering (SAXS) is a powerful structural technique to study dynamic DNA repair proteins. As toxic and mutagenic repair intermediates need to be prevented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531030f8007ef9c4fb891b0db32947c6
https://pubmed.ncbi.nlm.nih.gov/35290631

Target highlights in CASP14 : Analysis of models by structure providers

Autor: John A. Tainer, Youngchang Kim, Andrei N. Lupas, Athanassios Adamopoulos, Karolina Michalska, Rhys Grinter, Rosalba Lepore, Andrea Ilari, Anastassis Perrakis, Christopher S. Hayes, Leila Tamara Alexander, Torsten Schwede, Cécile Breyton, Prasun K. Mukherjee, Wah Chiu, Mauricio Valdivia-Delgado, Maya Topf, Markus Alahuhta, Susan E. Tsutakawa, Marcus D. Hartmann, Yannick J. Bomble, Valerio Chiarini, Cihan Makbul, Tatjana Heidebrecht, Andrew L. Lovering, William Sam Nutt, Gagan D. Gupta, Bettina Böttcher, John Moult, Andriy Kryshtafovych, Andrzej Joachimiak, Lucy Stols, Ann M. Arvin, Naga Babu Chinnam, Vladimir V. Lunin, Stefan L. Oliver, Romain Linares, Krzysztof Fidelis

Publikováno v: Proteins-Structure, Function and Bioinformatics
Proteins-Structure, Function and Bioinformatics, Wiley, In press, ⟨10.1002/prot.26247⟩
Proteins, vol 89, iss 12
Proteins-Structure, Function and Bioinformatics, In press, ⟨10.1002/prot.26247⟩

International audience; The biological and functional significance of selected Critical Assessment of Techniques for Protein Structure Prediction 14 (CASP14) targets are described by the authors of the structures. The authors highlight the most relev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7557d9b2df136d9d1571decbe5cebcd
https://hal.univ-grenoble-alpes.fr/hal-03384556

Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages

Autor: Irene W. Ng, Porsha L. R. Shaw, Maria A. Schumacher, Naga Babu Chinnam, Nam K. Tonthat, Anne K. Kalliomaa-Sanford, J. E. Lee, Fernando A. Rodriguez-Castañeda, Madhuri T. Barge, Daniela Barillà

Publikováno v: Science. 349:1120-1124

Plasmid partitioning superstructure system Partitioning and sharing DNA between dividing cells is critical for all domains of life. Prokaryotes must share certain plasmids as well as their genomic DNA to survive. Schumacher et al. studied the partiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9136227f46843c71b4bbd1c3fd1a4520
https://doi.org/10.1126/science.aaa9046

Tetrameric c-di-GMP Mediates Effective Transcription Factor Dimerization to Control Streptomyces Development

Autor: Natalia Tschowri, Mark J. Buttner, Kim Findlay, Richard G. Brennan, Maria A. Schumacher, Naga Babu Chinnam, Susan Schlimpert

Publikováno v: Cell. 158:1136-1147

SummaryThe cyclic dinucleotide c-di-GMP is a signaling molecule with diverse functions in cellular physiology. Here, we report that c-di-GMP can assemble into a tetramer that mediates the effective dimerization of a transcription factor, BldD, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a06fc3c44923197503dcaf2ae2fa1ae
https://doi.org/10.1016/j.cell.2014.07.022