Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Nafsika H. Georgopapadakou"'
Publikováno v:
Drug Resistance Updates. 10:182-193
The Annual Meeting of the American Association for Cancer Research (AACR) brings together research in fundamental biology, translational science, drug development and clinical testing of emerging anticancer therapies. Among the highlights of the 2007
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90a6689c83a24c71ed3d0e90759e1d17
https://doi.org/10.1016/j.drup.2007.07.001
https://doi.org/10.1016/j.drup.2007.07.001
Autor:
Nafsika H. Georgopapadakou
Publikováno v:
Expert Opinion on Investigational Drugs. 16:1-10
This perspective is the fifth in a series discussing drugs dropped from development in 2005, of which 11 were being developed for infectious diseases. Of these, eight were antivirals and were dropped in Phase II or III: Medivir's alovudine, Ono Pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a98ce4dfdf4b4a9a02ee2d23f172376
https://doi.org/10.1517/13543784.16.1.1
https://doi.org/10.1517/13543784.16.1.1
Publikováno v:
European Journal of Biochemistry. 124:507-512
The monobactams are a novel family of monocyclic beta-lactam antibiotics characterized by the 2-oxoazetidine-1-sulfonic acid moiety. A series of monobactams bind covalently to the Streptomyces R61 DD-carboxypeptidase in a manner similar to that for b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe390f8682354128fc442cc230ef393
https://doi.org/10.1111/j.1432-1033.1982.tb06622.x
https://doi.org/10.1111/j.1432-1033.1982.tb06622.x
Publikováno v:
Drug Resistance Updates, 8(4), 183-197. Churchill Livingstone
Broxterman, H J & Georgopapadakou, NH 2005, ' Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations ', Drug Resistance Updates, vol. 8, no. 4, pp. 183-197 . https://doi.org/10.1016/j.drup.2005.07.002
Broxterman, H J & Georgopapadakou, NH 2005, ' Anticancer therapeutics: "Addictive" targets, multi-targeted drugs, new drug combinations ', Drug Resistance Updates, vol. 8, no. 4, pp. 183-197 . https://doi.org/10.1016/j.drup.2005.07.002
The annual meeting of the American Association for Cancer Research (AACR) provided a panoramic view of new developments and trends in cancer research. In the area of new drug development, a recurrent theme was receptor tyrosine kinase (TK) inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeaf93549b860f5c1f6e79a1229facd3
https://hdl.handle.net/1871/44469
https://hdl.handle.net/1871/44469
Publikováno v:
Drug Resistance Updates. 7:79-87
The International Conference on Molecular Targets and Therapeutics, jointly sponsored by the American Association for Cancer Research (AACR), National Cancer Institute (NCI) and European Organization for Research and Treatment of Cancer (EORTC), was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c89384ea23ac2a66da715f19b29a0c7
https://doi.org/10.1016/j.drup.2004.02.004
https://doi.org/10.1016/j.drup.2004.02.004
Autor:
Nafsika H. Georgopapadakou
Publikováno v:
Drug Resistance Updates. 5:181-191
The 41st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) was held in Chicago on 16-19 December 2001, rescheduled following the tragic events of 11th September. Nonetheless, it attracted thousands of delegates from industry an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf28c148f96bf22488daaba0a70e17f7
https://doi.org/10.1016/s1368-7646(02)00088-2
https://doi.org/10.1016/s1368-7646(02)00088-2
Autor:
Nafsika H. Georgopapadakou
Publikováno v:
Expert Opinion on Investigational Drugs. 11:1117-1125
Invasive fungal infections have increased dramatically in recent years to become important causes of morbidity and mortality in hospitalised patients. Currently available antifungal drugs for such infections essentially have three molecular targets:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e45765f9dc8e818e32b768ca398bfab
https://doi.org/10.1517/13543784.11.8.1117
https://doi.org/10.1517/13543784.11.8.1117
Autor:
Nafsika H. Georgopapadakou
Publikováno v:
Drug Resistance Updates. 3:265-269
40th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) was held in Toronto on 17-20 September 2000. It attracted thousands of delegates from industry and academia and covered, in over 2300 oral and poster presentations, topics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711eb45d93257b1d9cfe9d5f8b4aa56e
https://doi.org/10.1054/drup.2000.0168
https://doi.org/10.1054/drup.2000.0168
Autor:
Nafsika H. Georgopapadakou
Publikováno v:
Expert Opinion on Investigational Drugs. 9:1787-1796
Currently available antifungal drugs for serious infections have essentially two molecular targets, 14alpha demethylase (azoles) and ergosterol (polyenes). The former is a fungistatic target, vulnerable to resistance development; the latter, while a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461c3e4cb11872c52911e5da9975d9b6
https://doi.org/10.1517/13543784.9.8.1787
https://doi.org/10.1517/13543784.9.8.1787
Publikováno v:
FEBS Letters. 463:241-244
Inositol phosphorylceramide synthase (IPC synthase) is an essential and unique enzyme in fungal sphingolipid biosynthesis and is the target of the cyclic nonadepsipeptide antibiotic aureobasidin A. As a first step towards understanding the mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc127af25ffe48173b352b03643af560
https://doi.org/10.1016/s0014-5793(99)01633-6
https://doi.org/10.1016/s0014-5793(99)01633-6