Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nafisa Ghori"'
Publikováno v:
Hepatology. 47:2026-2035
The proteasomal and lysosomal/autophagy pathways in the liver and other tissues are involved in several biological processes including the degradation of misfolded proteins. Exposure of hepatocyte cell lines to proteasome inhibitors (PIs) results in
Publikováno v:
Molecular Microbiology. 55:954-972
Summary Salmonella enterica serovar Typhimurium (S. typhimurium) infects a wide variety of mammalian hosts and in rodents causes a typhoid-like systemic disease involving replication of bacteria inside macrophages within reticuloendothelial tissues.
Autor:
Philippe Herbomel, Nafisa Ghori, Jessica L. Lewis, Lalita Ramakrishnan, J. Muse Davis, Hilary Clay
Publikováno v:
Immunity. 17(6):693-702
Infection of vertebrate hosts with pathogenic Mycobacteria, the agents of tuberculosis, produces granulomas, highly organized structures containing differentiated macrophages and lymphocytes, that sequester the pathogen. Adult zebrafish are naturally
Bile-induced 'pili' in Campylobacter jejuni are bacteria-independent artifacts of the culture medium
Publikováno v:
Molecular Microbiology. 39:1546-1549
In 1996, it was reported that the enteric pathogen Campylobacter jejuni produces pilus-like appendages in response to bile salts such as deoxycholate (DOC), and that the formation of these appendages requires the putative peptidase PspA. Pili were kn
Autor:
Nafisa Ghori, David S. Hersh, Arturo Zychlinsky, Stanley Falkow, Donna M. Bouley, Denise M. Monack
Publikováno v:
The Journal of Experimental Medicine
Salmonella typhimurium invades host macrophages and induces apoptosis and the release of mature proinflammatory cytokines. SipB, a protein translocated by Salmonella into the cytoplasm of macrophages, is required for activation of Caspase-1 (Casp-1,
Autor:
David S. Hersh, Nafisa Ghori, Stanley Falkow, Arturo Zychlinsky, Denise M. Monack, Mark R. Smith
Publikováno v:
Proceedings of the National Academy of Sciences. 96:2396-2401
Recently,Salmonellaspp. were shown to induce apoptosis in infected macrophages. The mechanism responsible for this process is unknown. In this report, we establish that the Inv-Spa type III secretion apparatus target invasin SipB is necessary and suf
Publikováno v:
Journal of Neuroscience Research. 51:463-472
A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occu
Publikováno v:
Proceedings of the National Academy of Sciences. 94:10385-10390
PathogenicYersiniaspp. carry a large common plasmid that encodes a number of essential virulence determinants. Included in these factors are theYersinia-secreted proteins called Yops. We analyzed the consequences of wild-type and mutant strains ofYer
Publikováno v:
Proceedings of the National Academy of Sciences. 92:9181-9185
The human malaria parasite Plasmodium falciparum contains sphingomyelin synthase in its Golgi apparatus and in a network of tubovesicular membranes in the cytoplasm of the infected erythrocyte. Palmitoyl and decanoyl analogues of 1-phenyl-2-acylamino
Publikováno v:
Journal of Experimental Medicine. 180:15-23
Salmonella species are known to initiate infection of mammalian hosts by penetrating the intestinal epithelium of the small bowel. These bacteria preferentially interact with Peyer's patches which are collections of lymphoid follicles making up the g