Tert-butylhydroquinone and tert-butylcatechol positivity as warning lights of skin sensitization to tert-butylphenol derivatives in adhesives and diabetes devices.

Autor: Dendooven E; Department of Dermatology, University Hospital Antwerp (UZA) and University of Antwerp (UA), Antwerp, Belgium.; Natural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Naessens T; Natural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Foubert K; Natural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Hermans N; Natural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Aerts O; Department of Dermatology, University Hospital Antwerp (UZA) and University of Antwerp (UA), Antwerp, Belgium.

Publikováno v: Contact dermatitis [Contact Dermatitis] 2024 Nov; Vol. 91 (5), pp. 387-391. Date of Electronic Publication: 2024 Aug 21.

Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation

Autor: Dejager, L, Dendoncker, K, Eggermont, M, Souffriau, J, Van Hauwermeiren, F, Willart, M, Van Wonterghem, E, Naessens, T, Ballegeer, M, Vandevyver, S, Hammad, H, Lambrecht, B, De Bosscher, K, Grooten, J, Libert, C

Publikováno v: In Mucosal Immunology November 2015 8(6):1212-1225

Discovery of the Potent and Selective Inhaled Janus Kinase 1 Inhibitor AZD4604 and Its Preclinical Characterization.

Autor: Nilsson M; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Berggren K; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Berglund S; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Cerboni S; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Collins M; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Dahl G; Structure and Biophysics, Research and Early Development, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Elmqvist D; Early Product Development, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Grimster NP; Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States., Hendrickx R; DMPK, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Johansson JR; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Kettle JG; Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States., Lepistö M; Medicinal Chemistry, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Rhedin M; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Smailagic A; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Su Q; Oncology R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States., Wennberg T; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Wu A; Discovery Sciences, R&D, AstraZeneca R&D, Waltham, Massachusetts 02451, United States., Österlund T; Mechanistic Biology & Profiling, Research and Early Development, Discovery Science, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Naessens T; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden., Mitra S; Bioscience, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg SE-431 83, Sweden.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Oct 12; Vol. 66 (19), pp. 13400-13415. Date of Electronic Publication: 2023 Sep 22.

Non-heme iron overload impairs monocyte to macrophage differentiation via mitochondrial oxidative stress.

Autor: Cui Y; Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Gutierrez S; Bioscience Cardiovascular, Early Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Ariai S; Early Product Development, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Öberg L; Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Thörn K; Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Gehrmann U; Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Cloonan SM; Division of Pulmonary and Critical Care Medicine, Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College, New York, NY, United States.; School of Medicine, Trinity Biomedical Sciences Institute and Tallaght University Hospital, Trinity College Dublin, Dublin, Ireland., Naessens T; Bioscience Cough & In vivo, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Olsson H; Translational Science & Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Oct 21; Vol. 13, pp. 998059. Date of Electronic Publication: 2022 Oct 21 (Print Publication: 2022).

Identification and Quantification of Polymethoxylated Flavonoids in Different Citrus Species Using UPLC-QTOF-MS/MS and HPLC-DAD.

Autor: Brits M; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Naessens T; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Theunis M; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Taktak O; Laboratory of Organic Chemistry (Natural Substances Team) LR17ES08, Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia., Allouche N; Laboratory of Organic Chemistry (Natural Substances Team) LR17ES08, Faculty of Sciences of Sfax, University of Sfax, Sfax, Tunisia., Pieters L; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium., Foubert K; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Antwerp, Belgium.

Publikováno v: Planta medica [Planta Med] 2021 Oct; Vol. 87 (12-13), pp. 1080-1088. Date of Electronic Publication: 2021 Aug 19.