Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Naeem Mahmood"'
Autor:
Fatima Muccee, Naeem Mahmood Ashraf, Suhail Razak, Tayyaba Afsar, Nadia Hussain, Fohad Mabood Husain, Huma Shafique
Publikováno v:
Journal of Ovarian Research, Vol 17, Iss 1, Pp 1-14 (2024)
Abstract Background Polycystic Ovary Syndrome (PCOS) affects a significant proportion of human females worldwide and is characterized by hormonal, metabolic, and reproductive dysfunctions, including infertility, irregular menstrual cycles, acanthosis
Externí odkaz:
https://doaj.org/article/4a2e880d29614fc8a80ce6ff2c2781db
Autor:
Amna Hafeez, Maria Shabbir, Khushbukhat Khan, Janeen H. Trembley, Yasmin Badshah, Sameen Zafar, Kanza Shahid, Hania Shah, Naeem Mahmood Ashraf, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Afifa Marium, Suhail Razak
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-12 (2024)
Abstract Background Single nucleotide polymorphisms (SNPs) have been linked with prostate cancer (PCa) and have shown potential as prognostic markers for advanced stages. Loss of function mutations in PKCι have been linked with increased risk of mal
Externí odkaz:
https://doaj.org/article/7bdd5663135e429f9ba26e50ca32aa0e
Autor:
Khushbukhat Khan, Sameen Zafar, Yasmin Badshah, Naeem Mahmood Ashraf, Mehak Rafiq, Lubna Danish, Maria Shabbir, Janeen H. Trembley, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background Gynecologic cancers comprise malignancies in the female reproductive organs. Ovarian cancer ranks sixth in terms of incidence rates while seventh in terms of mortality rates. The stage at which ovarian cancer is diagnosed mainly d
Externí odkaz:
https://doaj.org/article/fa654053675642f1a0b52271742e231e
Autor:
Sameen Zafar, Khushbukhat Khan, Yasmin Badshah, Kanza Shahid, Janeen H. Trembley, Amna Hafeez, Naeem Mahmood Ashraf, Hamid Arslan, Maria Shabbir, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-15 (2023)
Abstract Background Protein Kinase C-epsilon (PKCε) is a member of the novel subfamily of PKCs (nPKCs) that plays a role in cancer development. Studies have revealed that its elevated expression levels are associated with cervical cancer. Previously
Externí odkaz:
https://doaj.org/article/209bc828e2ab4024aa791f64fbdfcef4
Autor:
Naila Khan, Khushbukhat Khan, Yasmin Badshah, Janeen H. Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Lubna Danish, Tayyaba Afsar, Ali Almajwal, Saira Justin, Zafarul Hasan, Suhail Razak
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-6 (2023)
Abstract Hepatocellular carcinoma is a leading cause of cancer-related deaths due to its complexity in diagnosis, chemo-resistance, and aggressive nature. Identifying pathogenic single nucleotide polymorphism (SNP) in protein kinase C iota (PKCι) ca
Externí odkaz:
https://doaj.org/article/9f6f7f17344743f188086ee83463e55b
Autor:
Fizzah Abid, Khushbukhat Khan, Yasmin Badshah, Naeem Mahmood Ashraf, Maria Shabbir, Arslan Hamid, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-24 (2023)
Abstract Background PRKCG encodes PKC γ, which is categorized under the classical protein kinase C family. No studies have specifically established the relationship between PRKCG nsSNPs with structural and functional variations in PKC γ in the cont
Externí odkaz:
https://doaj.org/article/eca0b66a0ed24e0aac0fd4ff7b6278e2
Autor:
Areeba Rehman, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Ali Alshamari, Tariq Nahar Alanezi, Suhail Razak
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-7 (2023)
Abstract Background The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis. The PKCε isozyme is an oncogene k
Externí odkaz:
https://doaj.org/article/ca83bf0fa5f942b895d5fb2d3508a580
Autor:
Khushbukhat Khan, Sameen Zafar, Amna Hafeez, Yasmin Badshah, Kanza Shahid, Naeem Mahmood Ashraf, Maria Shabbir
Publikováno v:
RNA Biology, Vol 19, Iss 1, Pp 1115-1129 (2022)
Untranslated regions of the gene play a crucial role in gene expression regulation at mRNA and protein levels. Mutations at UTRs impact expression by altering transcription factor binding, transcriptional/translational efficacy, miRNA-mediated gene r
Externí odkaz:
https://doaj.org/article/e286b97ea0b249b586c3712d42e1d333
Autor:
Fizzah Abid, Talha Iqbal, Khushbukhat Khan, Yasmin Badshah, Janeen H Trembley, Naeem Mahmood Ashraf, Maria Shabbir, Tayyaba Afsar, Ali Almajwal, Suhail Razak
Publikováno v:
Biomarker Research, Vol 10, Iss 1, Pp 1-11 (2022)
Abstract Background HCC is a major health concern worldwide. PKC gamma, a member of the conventional PKC subclass, is involved in many cancer types, but the protein has received little attention in the context of single nucleotide polymorphisms and H
Externí odkaz:
https://doaj.org/article/c418dbd2e877404c8689f13b24aa6ca2
Autor:
Sarah Sadiq, Mohammad Zeeshan Anwar, Huma Shafique, Syed Mohsin Manzoor, Shaiza Shoaib, Rabia Hamid, Shoaib Naiyer Hashmi, Naeem Mahmood Ashraf, Tayyaba Afsar, Mashooq Ahmad Bhat, Suhail Razak
Publikováno v:
Medicina, Vol 60, Iss 3, p 368 (2024)
Background and Objectives: A polymorphism in the promoter region of the IL-6 gene would influence the level of IL-6 expression in patients with HCV, resulting in a pro-inflammatory response. Few studies have shown the association between −174G>C (r
Externí odkaz:
https://doaj.org/article/f41042139ea14ae7991ed4ecd9a3c853