Výsledky vyhledávání - "Naeem B. Hanna"

Synthesis of Some 6-Substituted 5-Azacytidines

Autor: Naeem B. Hanna, Alois Piskala, Milena Masojidkova, Pavel Fiedler

Publikováno v: Collection of Czechoslovak Chemical Communications. 63:222-230

Protected 6-substituted benzyl, phenyl and chloromethyl derivatives of 5-azacytidine 8-10 have been prepared by addition of phenylacetyl- (2), benzoyl- (3) or (chloroacetyl)guanidine (4) to 2,3,5-tri-O-benzoyl-β-D-ribosyl isocyanate (1) and subseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8de139a37a9d10c2b939bf597134488f
https://doi.org/10.1135/cccc19980222

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Ultrafast Cleavage and Deprotection of Oligonucleotides Synthesis and Use of CAcDerivatives

Autor: Naeem B. Hanna, Firdous Farooqui, M. P. Reddy

Publikováno v: Nucleosides and Nucleotides. 16:1589-1598

We have investigated the use of alkylamines as fast cleavage and deprotection reagents for the solid phase synthesis of oligonucleotides and found methylamine/ammonium hydroxide (or methylamine) as an efficient reagent. The transamination side produc

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https://doi.org/10.1080/07328319708006236

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6-Methyl-5-Azacytidine-Synthesis, Conformational Properties and Biological Activity. A Comparison of Molecular Conformation with 5-Azacytidine

Autor: Alois Piskala, Naeem B. Hanna, Jaroslav Zajíček

Publikováno v: Nucleosides and Nucleotides. 16:129-144

The title compound was prepared by the isocyanate procedure and the tri-methylsilyl method. The measurement of 1H NMR spectrum of 6-methyl-5-azacytidine (1) revealed a preference of γt (46%) rotamer around C(5′)-C(4′) bond, a predominance of N c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc2bdf4e70a9e7abe66a88b30bdf09e0
https://doi.org/10.1080/07328319708002528

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Elimination of transamination side product by the use of dCAc methylphosphonamidite in the synthesis of oligonucleoside methylphosphonates

Autor: Naeem B. Hanna, Firdous Farooqui, Meda Parameswara Reddy

Publikováno v: Tetrahedron Letters. 37:8691-8694

The transamination side product formed by the use of dC bz or dC ibu methylphosphonamidite upon treatment with ethylenediamine has been eliminated by the use of dC Ac methylphosphonamidite. The synthesis and characterization of DMT dC Ac methylphosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::acfc0099c97e4d1a1edaaac9e11179e2
https://doi.org/10.1016/s0040-4039(96)02011-4

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Methylamine deprotection provides increased yield of oligoribonucleotides

Autor: Naeem B. Hanna, M.P. Reddy, Firdous Farooqui

Publikováno v: Tetrahedron Letters. 36:8929-8932

Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of Oligoribonucleotides has significantly increased the yield of the full length Oligoribonucleotides as compared to the use of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::251a8894c20bf37fca4edd3bd93da745
https://doi.org/10.1016/0040-4039(95)01953-f

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Fast cleavage and deprotection of oligonucleotides

Autor: Naeem B. Hanna, M. P. Reddy, Firdous Farooqui

Publikováno v: Tetrahedron Letters. 35:4311-4314

We have developed methylamine/ammonia as a fast cleavage and deprotection reagent which effects complete cleavage of oligonucleotides from the solid support in 5 min at room temperature and complete deprotection in 5 min at 65°C. The problem of tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7d6e594091aee8b4af7f34605121e36
https://doi.org/10.1016/s0040-4039(00)73341-7

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Sulfinosine congeners: synthesis and antitumor activity in mice of certain N9-alkylpurines and purine ribonucleosides

Autor: Naeem B. Hanna, Thomas L. Avery, Ganapathi R. Revankar, B. K. Bhattacharya, Roland K. Robins

Publikováno v: Journal of Medicinal Chemistry. 37:177-183

A number of N9-alkyl-substituted purines and purine ribonucleosides have been synthesized as congeners of sulfinosine and evaluated for their antileukemic activity in mice. NaH-mediated alkylation of 6-chloropurine (4) and 2-amino-6-chloropurine (5)

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https://doi.org/10.1021/jm00027a022

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ChemInform Abstract: Synthesis and Single-Crystal X-Ray Diffraction Analysis of 2- Sulfamoyladenosine (6-Amino-9-β-D-ribofuranosylpurine-2- sulfonamide)

Autor: Ganapathi R. Revankar, Roland K. Robins, Steven B. Larson, Naeem B. Hanna

Publikováno v: ChemInform. 22

2-Amino-9-β-D-ribofuranosylpurine-2-sulfonamide (2-sulfamoyladenosine, 4), a congener of sulfonosine (3), was synthesized by four different routes. Acid catalyzed fusion of 6-chloropurine-2-sulfonyl fluoride (5) with 1,2,3,5-tetra-O-acetyl-β-D-ribo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::622d97f5eaf61745b1dcc6103e00847c
https://doi.org/10.1002/chin.199111326

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