Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nadya Al-Yacoub"'
Autor:
Raed Abu-Dawud, Bhavesh V. Mistry, Mohamed Rajab, Maha Alanazi, Nadya Al-Yacoub, Junaid Kashir, Falah Almohanna, Dilek Colak, Abdullah M. Assiri
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract During mammalian spermatogenesis, the ubiquitin proteasome system maintains protein homoeostasis (proteastasis) and spermatogenic cellular functions. DCAF17 is a substrate receptor in the ubiquitin CRL4 E3 Ligase complex, absence of which ca
Externí odkaz:
https://doaj.org/article/594792049e564ec1950eaa5c3ef77cf5
Autor:
Nadya Al-Yacoub, Dilek Colak, Salma Awad Mahmoud, Maya Hammonds, Kunhi Muhammed, Olfat Al-Harazi, Abdullah M. Assiri, Jehad Al-Buraiki, Waleed Al-Habeeb, Coralie Poizat
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Al-Yacoub et al. investigate the consequences of FBXO32 mutation on dilated cardiomyopathy. ER stress, abnormal CHOP activation and CHOP-induced apoptosis with no UPR effector activation are found to underlie the FBXO32 mutation induced cardiomyopath
Externí odkaz:
https://doaj.org/article/9414570eeefe4652ac8f265170617ea4
Autor:
Junaid Kashir, Bhavesh V Mistry, Maha Adel Gumssani, Muhammad Rajab, Reema Abu-Dawas, Falah AlMohanna, Michail Nomikos, Celine Jones, Raed Abu-Dawud, Nadya Al-Yacoub, Kevin Coward, F Anthony Lai, Abdullah M Assiri
Publikováno v:
Asian Journal of Andrology, Vol 23, Iss 2, Pp 178-187 (2021)
Sperm-specific phospholipase C zeta (PLCζ) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation and absence/reduction of PLC
Externí odkaz:
https://doaj.org/article/1cc4546088f94a80ad9b06c67b3737c6
Autor:
Kunhi Muhammed, Abdullah M. Assiri, Dilek Colak, Salma Awad Mahmoud, Maya Hammonds, Jehad Al-Buraiki, Waleed AlHabeeb, Olfat Al-Harazi, Coralie Poizat, Nadya Al-Yacoub
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology
Endoplasmic reticulum (ER) stress induction of cell death is implicated in cardiovascular diseases. Sustained activation of ER-stress induces the unfolded protein response (UPR) pathways, which in turn activate three major effector proteins. We previ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2708622af25f21bc1bd7eea17d5d22af
https://doaj.org/article/9414570eeefe4652ac8f265170617ea4
https://doaj.org/article/9414570eeefe4652ac8f265170617ea4
Autor:
Raed Abu-Dawud, MahaAdel Gumssani, BhaveshV Mistry, Reema B. Abu-Dawas, Kevin Coward, AbdullahM Assiri, FAnthony Lai, Muhammad Rajab, Celine Jones, Nadya Al-Yacoub, Junaid Kashir, Falah Al-Mohanna, Michail Nomikos
Publikováno v:
Asian Journal of Andrology
Asian Journal of Andrology, Vol 23, Iss 2, Pp 178-187 (2021)
Asian Journal of Andrology, Vol 23, Iss 2, Pp 178-187 (2021)
Sperm-specific phospholipase C zeta (PLCζ) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation and absence/reduction of PLC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef649c214b3c699e6dceeb0f6075aa30
http://europepmc.org/articles/PMC7991809
http://europepmc.org/articles/PMC7991809
Autor:
Raed Abu-Dawud, Bhavesh V. Mistry, Renad Almahdali, Maryam M. Matin, Ayodele Alaiya, Fatimah Alghamdi, Hala Alamari, Nadya Al-Yacoub, Junaid Kashir, Marwa Houssein, Abdullah Alawad, Peter W. Andrews, Abdullah M. Assiri
Publikováno v:
Tissue and Cell. 78:101893
DPPA4 is essential for the pluripotent stem cell state, yet its function is poorly understood. DPPA4 is localized in the nucleus, where it is associated with active chromatin. We now report that it is also present in the cytosol, where it appears as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d804a404d21352221ae62587e46933
https://doi.org/10.1016/j.tice.2022.101893
https://doi.org/10.1016/j.tice.2022.101893
Autor:
Michail Nomikos, Reema B. Abu-Dawas, Nadya Al-Yacoub, Junaid Kashir, Serdar Coskun, Bhavesh V. Mistry, Abdullah M. Assiri, Saad Al-Hassan, F. Anthony Lai, Raed Abu-Dawud, Ahmed Ajlan, Lujain BuSaleh
Publikováno v:
AndrologyREFERENCES. 8(5)
Oocyte activation is driven by intracellular calcium (Ca ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc527e7e3f20fdce6eb3cd8d71a60d2
https://pubmed.ncbi.nlm.nih.gov/32298520
https://pubmed.ncbi.nlm.nih.gov/32298520
Autor:
Muhammad Kunhi, Naglaa F. El-Orabi, Nadya Al Yacoub, Lama Fawaz Pharaon, Salma Awad, Coralie Poizat
Publikováno v:
Toxicology letters. 280
Rosiglitazone is an anti-diabetic agent that raised a major controversy over its cardiovascular adverse effects. There is in vivo evidence that Rosiglitazone promotes cardiac hypertrophy by PPAR-γ-independent mechanisms. However, whether Rosiglitazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce3a5485b9aa32574cfa76e352f2aa9
https://pubmed.ncbi.nlm.nih.gov/28822817
https://pubmed.ncbi.nlm.nih.gov/28822817
Autor:
Mustafa A. Salih, Fowzan S. Alkuraya, Salma Awad, Mohammed S. Al-Dosari, Nadya Al-Yacoub, Coralie Poizat, Dilek Colak
Publikováno v:
Human Molecular Genetics. 22:2200-2213
Primary microcephaly (PM) is a developmental disorder of early neuroprogenitors that results in reduction of the brain mass, particularly the cortex. To gain fresh insight into the pathogenesis of PM, we describe a consanguineous family with a novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2d75ca6f1322e650cc8c9f1909c0fa
https://doi.org/10.1093/hmg/ddt072
https://doi.org/10.1093/hmg/ddt072
Publikováno v:
Circulation Research. 119
Background: Dilated cardiomyopathy (DCM) is a common form of cardiomyopathy causing systolic dysfunction and heart failure. Rare variants in more than 30 genes mostly encoding sarcomeric proteins and proteins of the extracellular matrix have been imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2a5c3a686f1782214d49aaa2cff77e0
https://doi.org/10.1161/res.119.suppl_1.390
https://doi.org/10.1161/res.119.suppl_1.390