Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Nady Roodi"'
Publikováno v:
Annals of the New York Academy of Sciences. 1155:68-75
Oxidative metabolites of estrogens have been implicated in the development of breast cancer, yet relatively little is known about the metabolism of estrogens in the normal breast. We developed an experimental in vitro model of mammary estrogen metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15370f68640cfb67a3df33656140a509
https://doi.org/10.1111/j.1749-6632.2008.03676.x
https://doi.org/10.1111/j.1749-6632.2008.03676.x
Publikováno v:
Cancer Research. 67:812-817
The oxidative metabolism of estrogens has been implicated in the development of breast cancer; yet, relatively little is known about the mechanism by which estrogens cause DNA damage and thereby initiate mammary carcinogenesis. To determine how the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272d8b123a1003c0b8d5c50f676484d2
https://doi.org/10.1158/0008-5472.can-06-2133
https://doi.org/10.1158/0008-5472.can-06-2133
Publikováno v:
Chemical Research in Toxicology. 17:1258-1264
Estrogens and their oxidative metabolites, the catechol estrogens, have been implicated in the development of breast cancer; yet, relatively little is known about estrogen metabolism in the breast. To determine how the parent hormone, 17 beta-estradi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5debda73842384ce15da0435aaec5864
https://doi.org/10.1021/tx0498657
https://doi.org/10.1021/tx0498657
Autor:
William D. Dupont, Fritz F. Parl, Nady Roodi, L. Renee Bailey, Marylyn D. Ritchie, Jason H. Moore, Lance W. Hahn
Publikováno v:
The American Journal of Human Genetics. 69:138-147
One of the greatest challenges facing human geneticists is the identification and characterization of susceptibility genes for common complex multifactorial human diseases. This challenge is partly due to the limitations of parametric-statistical met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44218091aa456ccc7d077ac1aba7314
https://doi.org/10.1086/321276
https://doi.org/10.1086/321276
Publikováno v:
Endocrine Related Cancer. 2:293-309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242d30ffb1681208481b0f11ecab555d
https://doi.org/10.1677/erc.0.0020293
https://doi.org/10.1677/erc.0.0020293
Autor:
Melinda E. Sanders, Sheila Dawling, Fritz F. Parl, Peggy A. Schuyler, Hiltrud Brauch, Philip S. Crooke, W. Dale Plummer, Jeffrey R. Smith, Kathryn S. P. Higginbotham, Nady Roodi, David L. Page, Christina Justenhoven, William D. Dupont
Background: Current models of breast cancer risk prediction do not directly reflect mammary estrogen metabolism or genetic variability in exposure to carcinogenic estrogen metabolites. Methods: We developed a model that simulates the kinetic effect o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067190baa387a15af107b49e0388ae4b
https://europepmc.org/articles/PMC3472969/
https://europepmc.org/articles/PMC3472969/
Autor:
Chastity Bradley, Raymond L. Mernaugh, Zu-Wen Sun, Riet van der Meer, Mahesh B. Chandrasekharan, Fritz F. Parl, Nady Roodi, Heping Yan
Publikováno v:
Carcinogenesis. 28(10)
Little is known about early carcinogen-induced protein alterations in mammary epithelium. Detection of early alterations would enhance our understanding of early-stage carcinogenesis. Here, normal human mammary epithelial cells (HMECs) were exposed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71566024a7c93496839a62f2d18827b
https://pubmed.ncbi.nlm.nih.gov/17468514
https://pubmed.ncbi.nlm.nih.gov/17468514
Autor:
Nady Roodi, Philip S. Crooke, Sheila Dawling, Marylyn D. Ritchie, Fritz F. Parl, David L. Hachey
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15(9)
Oxidative metabolites of estrogens have been implicated in the development of breast cancer, yet relatively little is known about the metabolism of estrogens in the normal breast. We developed a mathematical model of mammary estrogen metabolism based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657d3ce4c780c1fd5d043adb1a421834
https://pubmed.ncbi.nlm.nih.gov/16985022
https://pubmed.ncbi.nlm.nih.gov/16985022
Publikováno v:
Cancer research. 64(4)
More than 500 studies have examined the association of the glutathione S-transferase M1 (GSTM1) genotype with various malignancies yielding inconsistent results. The genotyping was based on a PCR assay that identified the GSTM1 null (−/−) genotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b00f32d47ba5cf5c72bc05f2dd1bc45
https://pubmed.ncbi.nlm.nih.gov/14973116
https://pubmed.ncbi.nlm.nih.gov/14973116
Publikováno v:
Cancer research. 63(23)
The Phase I enzyme cytochrome p450 1B1 (CYP1B1) has been postulated to play a key role in estrogen-induced mammary carcinogenesis by catalyzing the oxidative metabolism of 17beta-estradiol (E(2)) to catechol estrogens (2-OHE(2) and 4-OHE(2)) and high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::44a0cc52148ee6fdf1afb453570396a9
https://pubmed.ncbi.nlm.nih.gov/14679015
https://pubmed.ncbi.nlm.nih.gov/14679015