Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Nadr M, Jomha"'
Publikováno v:
npj Regenerative Medicine, Vol 6, Iss 1, Pp 1-13 (2021)
Abstract Preserving viable articular cartilage is a promising approach to address the shortage of graft tissue and enable the clinical repair of articular cartilage defects in articulating joints, such as the knee, ankle, and hip. In this study, we d
Externí odkaz:
https://doaj.org/article/39166fa9a73d45809d88af5bddf1cfa2
Autor:
Alexander R. A. Szojka, David Xinzheyang Li, Malou E. J. Sopcak, Zhiyao Ma, Melanie Kunze, Aillette Mulet-Sierra, Samer M. Adeeb, Lindsey Westover, Nadr M. Jomha, Adetola B. Adesida
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Meniscus fibrochondrocytes (MFCs) experience simultaneous hypoxia and mechanical loading in the knee joint. Experimental conditions based on these aspects of the native MFC environment may have promising applications in human meniscus tissue engineer
Externí odkaz:
https://doaj.org/article/8dcb5e4b7e43432d9ac2d4b2df2cf4a2
Autor:
Samia Rahman, Alexander R. A. Szojka, Yan Liang, Melanie Kunze, Victoria Goncalves, Aillette Mulet-Sierra, Nadr M. Jomha, Adetola B. Adesida
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
ObjectiveArticular cartilage of the knee joint is avascular, exists under a low oxygen tension microenvironment, and does not self-heal when injured. Human infrapatellar fat pad-sourced mesenchymal stem cells (IFP-MSC) are an arthroscopically accessi
Externí odkaz:
https://doaj.org/article/f0e4a17213264b52b79ff98593272bce
Autor:
Alexander RA Szojka, Rita de Cássia Marqueti, David Xinzheyang Li, Clayton W Molter, Yan Liang, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
Publikováno v:
Journal of Tissue Engineering, Vol 12 (2021)
This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined trea
Externí odkaz:
https://doaj.org/article/1872f10f7232417fa7d0fc28f4f8525a
Autor:
Alexander R A Szojka, Colleen N Moore, Yan Liang, Stephen H J Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249513 (2021)
[This corrects the article DOI: 10.1371/journal.pone.0248292.].
Externí odkaz:
https://doaj.org/article/f3cb232a82c44b9eb75210acb0f9f538
Autor:
Alexander R A Szojka, Colleen N Moore, Yan Liang, Stephen H J Andrews, Melanie Kunze, Aillette Mulet-Sierra, Nadr M Jomha, Adetola B Adesida
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248292 (2021)
Low oxygen and mechanical loading may play roles in regulating the fibrocartilaginous phenotype of the human inner meniscus, but their combination in engineered tissues remains unstudied. Here, we investigated how continuous low oxygen ("hypoxia") co
Externí odkaz:
https://doaj.org/article/a081f5cedfb645bab934725ca31e1033
Publikováno v:
Cryobiology. 109:53-61
Vitrification can extend the banking life of articular cartilage (AC) and improve osteochondral transplantation success. Current vitrification protocols require optimization to enable them to be implemented in clinical practice. Sucrose as a non-perm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d8f8e9aa07055dbc05e31e8b33a415
https://doi.org/10.1016/j.cryobiol.2022.09.004
https://doi.org/10.1016/j.cryobiol.2022.09.004
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Due to the complexity of articular interconnections and tenuous blood supply to the talus, talus fractures are often associated with complications (e.g., avascular necrosis). Currently, surgically fusing the talus to adjacent bones is widely used as
Externí odkaz:
https://doaj.org/article/cb72a6da2b6d483598c3808c9795143f
Publikováno v:
The Journal of Physical Chemistry B. 126:9566-9579
Cryopreserving articular cartilage by vitrification can increase the availability of tissue for osteochondral allograft transplantation to treat cartilage defects. Developing well-optimized vitrification protocols can be supported by mathematical mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7275aaa7ba627445a210d48887e21524
https://doi.org/10.1021/acs.jpcb.2c05736
https://doi.org/10.1021/acs.jpcb.2c05736
Autor:
Kezhou Wu, Kar Wey Yong, Maha Ead, Mark Sommerfeldt, Tamara D. Skene-Arnold, Lindsey Westover, Kajsa Duke, Leila Laouar, Janet A.W. Elliott, Nadr M. Jomha
Publikováno v:
The American Journal of Sports Medicine. 50:3671-3680
Background: The use of particulated articular cartilage for repairing cartilage defects has been well established, but its use is currently limited by the availability and short shelf life of donor cartilage. Vitrification is an ice-free cryopreserva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e7040371cd63d93768c05c5f66f8456
https://doi.org/10.1177/03635465221123045
https://doi.org/10.1177/03635465221123045