Inactivation of TRPM7 Kinase Targets AKT Signaling and Cyclooxygenase-2 Expression in Human CML Cells.

Autor: Hoeger B; Institute of Pharmacology, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz and Krankenhausstr. 5, 4020 Linz, Austria., Nadolni W; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Hampe S; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Hoelting K; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Fraticelli M; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Zaborsky N; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, 5020 Salzburg, Austria.; Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Müllner Hauptstr. 48, 5020 Salzburg, Austria.; Cancer Cluster Salzburg, 5020 Salzburg, Austria., Madlmayr A; Institute of Pharmacology, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz and Krankenhausstr. 5, 4020 Linz, Austria., Sperrer V; Institute of Pharmacology, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz and Krankenhausstr. 5, 4020 Linz, Austria., Fraticelli L; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Addington L; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Steinritz D; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Chubanov V; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Geisberger R; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, 5020 Salzburg, Austria.; Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Müllner Hauptstr. 48, 5020 Salzburg, Austria.; Cancer Cluster Salzburg, 5020 Salzburg, Austria., Greil R; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Paracelsus Medical University, 5020 Salzburg, Austria.; Salzburg Cancer Research Institute-Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Müllner Hauptstr. 48, 5020 Salzburg, Austria.; Cancer Cluster Salzburg, 5020 Salzburg, Austria., Breit A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Boekhoff I; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Gudermann T; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany., Zierler S; Institute of Pharmacology, Johannes Kepler University Linz, Altenbergerstr. 69, 4040 Linz and Krankenhausstr. 5, 4020 Linz, Austria.; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Goethestr. 33, 80336 Munich, Germany.

Publikováno v: Function (Oxford, England) [Function (Oxf)] 2023 Sep 15; Vol. 4 (6), pp. zqad053. Date of Electronic Publication: 2023 Sep 15 (Print Publication: 2023).

Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.

Autor: Hollenhorst MI; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Nandigama R; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany., Evers SB; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Gamayun I; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany., Abdel Wadood N; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Salah A; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany., Pieper M; Institute of Anatomy, University of Lübeck, and Airway Research Center North (ARCN), Lübeck, Germany.; German Center for Lung Research (DZL), Germany., Wyatt A; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany., Stukalov A; Immunopathology of Virus Infections Laboratory, Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany., Gebhardt A; Immunopathology of Virus Infections Laboratory, Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany., Nadolni W; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany., Burow W; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany., Herr C; Department of Internal Medicine V-Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany., Beisswenger C; Department of Internal Medicine V-Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany., Kusumakshi S; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany., Ectors F; FARAH Mammalian Transgenics Platform, Liège University, Liège, Belgium., Kichko TI; Institute of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Hübner L; Institute of Anatomy and Cell Biology, Julius-Maximilians-University, Würzburg, Germany., Reeh P; Institute of Physiology and Pathophysiology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany., Munder A; German Center for Lung Research (DZL), Germany.; Clinic for Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Hannover, Germany., Wienhold SM; Department of Infectious Diseases and Respiratory Medicine and Division of Pulmonary Inflammation, Charité - University Medicine Berlin, corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany., Witzenrath M; Department of Infectious Diseases and Respiratory Medicine and Division of Pulmonary Inflammation, Charité - University Medicine Berlin, corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany., Bals R; Department of Internal Medicine V-Pulmonology, Allergology, Intensive Care Medicine, Saarland University Hospital, Homburg, Germany., Flockerzi V; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany.; Center for Molecular Signaling., Gudermann T; German Center for Lung Research (DZL), Germany.; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany., Bischoff M; Institute for Medical Microbiology and Hygiene, and., Lipp P; Department of Infectious Diseases and Respiratory Medicine and Division of Pulmonary Inflammation, Charité - University Medicine Berlin, corporate member of Free University Berlin and Humboldt-University Berlin, Berlin, Germany.; Institute for Molecular Cell Biology and Research Center for Molecular Imaging and Screening, Saarland University, Homburg, Germany., Zierler S; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany.; Institute of Pharmacology, Johannes Kepler University Linz, Linz, Austria., Chubanov V; Walther-Straub-Institute for Pharmacology and Toxicology, Ludwig-Maximilians-University, Munich, Germany., Pichlmair A; Immunopathology of Virus Infections Laboratory, Institute of Virology, School of Medicine, Technical University of Munich, German Center for Infection Research (DZIF), Munich, Germany., König P; Institute of Anatomy, University of Lübeck, and Airway Research Center North (ARCN), Lübeck, Germany.; German Center for Lung Research (DZL), Germany., Boehm U; Institute for Experimental and Clinical Pharmacology and Toxicology, Saarland University, School of Medicine, Homburg, Germany.; Center for Molecular Signaling., Krasteva-Christ G; Institute of Anatomy and Cell Biology, Saarland University, School of Medicine, Homburg, Germany.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2022 Jul 01; Vol. 132 (13).

The voltage-gated potassium channel KV1.3 regulates neutrophil recruitment during inflammation.

Autor: Immler R; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Nadolni W; Walther-Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Goethestraße 33, 80336 Munich, Germany., Bertsch A; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Morikis V; Department of Biomedical Engineering, Graduate Group in Immunology, University of California, 451 E. Health Sciences Drive, Davis, CA 95616, USA., Rohwedder I; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Masgrau-Alsina S; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Schroll T; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Yevtushenko A; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Soehnlein O; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-Universität München, Pettenkofer Straße 8a, 80336 Munich, Germany.; Department of Physiology and Pharmacology (FyFa), Karolinska Institutet, Solnavägen 1, 17177 Stockholm, Sweden.; Institute for Experimental Pathology (ExPat), Center for Molecular Biology of Inflammation (ZMBE), Westfälische Wilhelms-Universität Münster, Von-Enmarch-Straße 56, 48149 Münster, Germany., Moser M; Institute of Experimental Hematology, School of Medicine, Technical University Munich, Einsteinstraße 25, 81675 Munich, Germany., Gudermann T; Walther-Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Goethestraße 33, 80336 Munich, Germany., Barnea ER; BioIncept LLC, New York, 140 East 40th Street #11E, NY 10016, USA., Rehberg M; Institute of Lung Biology and Disease, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany., Simon SI; Department of Biomedical Engineering, Graduate Group in Immunology, University of California, 451 E. Health Sciences Drive, Davis, CA 95616, USA., Zierler S; Walther-Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Goethestraße 33, 80336 Munich, Germany., Pruenster M; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany., Sperandio M; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Großhaderner Straße 9, 82152 Planegg-Martinsried, Germany.

Publikováno v: Cardiovascular research [Cardiovasc Res] 2022 Mar 25; Vol. 118 (5), pp. 1289-1302.

TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling.

Autor: Nadolni W; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Immler R; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Munich, Germany., Hoelting K; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Fraticelli M; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Ripphahn M; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Munich, Germany., Rothmiller S; Bundeswehr Institute of Pharmacology and Toxicology, Munich, Germany., Matsushita M; Department of Molecular and Cellular Physiology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan., Boekhoff I; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Gudermann T; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany., Sperandio M; Walter Brendel Centre of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-Universität München, Munich, Germany., Zierler S; Walther Straub Institute of Pharmacology and Toxicology, Ludwig-Maximilians-Universität München, Munich, Germany.; Institute of Pharmacology, Johannes Kepler University Linz, Linz, Austria.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Feb 15; Vol. 11, pp. 606893. Date of Electronic Publication: 2021 Feb 15 (Print Publication: 2020).

miR-125b 通过 Wnt/β-catenin 信号通路促进胃癌细胞上皮间质转化和转移.

Autor: 常 帅¹, 赵 耀¹, 李顺乐¹, 张 迪¹, 张 立¹, 翟宏军¹, 吉 鸿¹ jehoung@163.com

Publikováno v: Journal of Xi'an Jiaotong University (Medical Sciences). Sep2024, Vol. 45 Issue 5, p718-725. 8p.