Výsledky vyhledávání - "Nadja Mößlein"

Akademický článek

Structures in G proteins important for subtype selective receptor binding and subsequent activation

Autor: Volker Jelinek, Nadja Mösslein, Moritz Bünemann

Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)

With chimeric approach and biophysical (FRET) techniques, Jelinek, Mösslein & Bünemann elucidate coupling selectivity determinants of G proteins for two Gq-coupled receptors. They conclude that various regions, especially outside of the C-terminal

Externí odkaz: https://doaj.org/article/1ab50e3107bc4d848ea8d927ed419368

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Residency time of agonists does not affect the stability of GPCR-arrestin complexes

Autor: Nadja Mösslein, Lisa‐Marie Geertje Pohle, Anneke Fuss, Moritz Bünemann, Cornelius Krasel

Publikováno v: British Journal of Pharmacology

Background and purpose: The interaction of arrestins with G-protein coupled receptors (GPCRs) desensitizes agonist-dependent receptor responses and often leads to receptor internalization. GPCRs that internalize without arrestin have been classified

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d5f1ddfde7803cf77bf55e464ce507
https://hdl.handle.net/21.11116/0000-000A-66F5-F21.11116/0000-000A-66F7-D

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Orphan G Protein-Coupled Receptor GPRC5B Controls Smooth Muscle Contractility and Differentiation by Inhibiting Prostacyclin Receptor Signaling

Autor: Sarah Tonack, Wencai Zhao, Stefan Günther, Harmandeep Kaur, Nadja Mößlein, Jorge Carvalho, Ramesh Chennupati, Michael Kurz, Nina Wettschureck, Moritz Bünemann, Rui Li, Stefan Offermanns

Publikováno v: Circulation. 141(14)

Background: G protein–coupled receptors are important regulators of contractility and differentiation in vascular smooth muscle cells (SMCs), but the specific function of SMC-expressed orphan G protein–coupled receptor class C group 5 member B (G

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0219cc3993067f87ef1532029af17509
https://pubmed.ncbi.nlm.nih.gov/31941358

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Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Autor: Meritxell Canals, Martin Göldner, Moritz Bünemann, Cornelius Krasel, Julia G. Ruland, Nadja Mösslein, Elke Miess, Arsalan Yousuf, Ralph Steinborn, Yunshi Yang, Arisbel B. Gondin, MacDonald J. Christie, Stefan Schulz, Michelle L. Halls

Publikováno v: Science signaling. 11(539)

G protein receptor kinases (GRKs) and β-arrestins are key regulators of μ-opioid receptor (MOR) signaling and trafficking. We have previously shown that high-efficacy opioids such as DAMGO stimulate a GRK2/3-mediated multisite phosphorylation of co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354250343a5de84e0ded2e3cbc727a23
https://pubmed.ncbi.nlm.nih.gov/30018083

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