Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Nadja Krez"'
Autor:
Zheng Liu, Pyung-Gang Lee, Nadja Krez, Kwok-ho Lam, Hao Liu, Adina Przykopanski, Peng Chen, Guorui Yao, Sicai Zhang, Jacqueline M. Tremblay, Kay Perry, Charles B. Shoemaker, Andreas Rummel, Min Dong, Rongsheng Jin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Botulinum neurotoxin E (BoNT/E) is one of the major causes of human botulism and paradoxically also a promising therapeutic agent. Here we determined the co-crystal structures of the receptor-binding domain of BoNT/E (HCE) in complex with it
Externí odkaz:
https://doaj.org/article/689e4b646d7b448d89b2317de1ca4c69
Autor:
Maria B. Nowakowska, Katja Selby, Adina Przykopanski, Maren Krüger, Nadja Krez, Brigitte G. Dorner, Martin B. Dorner, Rongsheng Jin, Nigel P. Minton, Andreas Rummel, Miia Lindström
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeut
Externí odkaz:
https://doaj.org/article/be0f4d591b8f4c348fccdcb1b12a3fa8
Autor:
Kwok-ho Lam, Zhuojun Guo, Nadja Krez, Tsutomu Matsui, Kay Perry, Jasmin Weisemann, Andreas Rummel, Mark E. Bowen, Rongsheng Jin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
The translocation domain (HN) of Botulinum neurotoxins (BoNTs) mediates the delivery of the BoNT light chain (LC) into neuronal cytosol. Here the authors provide insights into HN membrane insertion by determining the crystal structure of BoNT/A1 HN a
Externí odkaz:
https://doaj.org/article/254881e40fb84f0690898f9dda9538c2
Autor:
Guorui Yao, Kwok-ho Lam, Jasmin Weisemann, Lisheng Peng, Nadja Krez, Kay Perry, Charles B. Shoemaker, Min Dong, Andreas Rummel, Rongsheng Jin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Antibody treatment is currently the only available countermeasure for botulism, a fatal illness caused by flaccid paralysis of muscles due to botulinum neurotoxin (BoNT) intoxication. Among the seven major serotypes of BoNT/A-G, BoNT/A poses
Externí odkaz:
https://doaj.org/article/28d488b3904246b2b17c6304fa26a9f6
Autor:
Jasmin Weisemann, Nadja Krez, Uwe Fiebig, Sylvia Worbs, Martin Skiba, Tanja Endermann, Martin B. Dorner, Tomas Bergström, Amalia Muñoz, Ingrid Zegers, Christian Müller, Stephen P. Jenkinson, Marc-Andre Avondet, Laurence Delbrassinne, Sarah Denayer, Reinhard Zeleny, Heinz Schimmel, Crister Åstot, Brigitte G. Dorner, Andreas Rummel
Publikováno v:
Toxins, Vol 7, Iss 12, Pp 5035-5054 (2015)
The detection and identification of botulinum neurotoxins (BoNT) is complex due to the existence of seven serotypes, derived mosaic toxins and more than 40 subtypes. Expert laboratories currently use different technical approaches to detect, identify
Externí odkaz:
https://doaj.org/article/cd0569736e8245beb5d14556569d6032
Autor:
Giulia Zanetti, Stefan Sikorra, Andreas Rummel, Nadja Krez, Elisa Duregotti, Samuele Negro, Tina Henke, Ornella Rossetto, Thomas Binz, Marco Pirazzini
Publikováno v:
PLoS Pathogens, Vol 13, Iss 8, p e1006567 (2017)
Botulinum neurotoxin serotype C (BoNT/C) is a neuroparalytic toxin associated with outbreaks of animal botulism, particularly in birds, and is the only BoNT known to cleave two different SNARE proteins, SNAP-25 and syntaxin. BoNT/C was shown to be a
Externí odkaz:
https://doaj.org/article/709a8fb2f91a4d94a1032d899d60280d
Autor:
Merja Joensuu, Parnayan Syed, Saber H Saber, Vanessa Lanoue, Tristan P Wallis, James Rae, Ailisa Blum, Rachel S Gormal, Christopher Small, Shanley Sanders, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael A Cousin, Ruby Cooper‐White, Justin J Cooper‐White, Brett M Collins, Robert G Parton, Giuseppe Balistreri, Andreas Rummel, Frédéric A Meunier
Publikováno v:
Joensuu, M, Syed, P, Saber, S H, Lanoue, V, Wallis, T P, Rae, J, Blum, A, Gormal, R S, Small, C, Sanders, S, Jiang, A, Mahrhold, S, Krez, N, Cousin, M A, Cooper-White, R, Cooper-White, J J, Collins, B M, Parton, R G, Balistreri, G, Rummel, A & Meunier, F A 2023, ' Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry ', EMBO Journal . https://doi.org/10.15252/embj.2022112095
The unique nerve terminal targeting of botulinum neurotoxin type A (BoNT/A) is due to its capacity to bind two receptors on the neuronal plasma membrane: polysialoganglioside (PSG) and synaptic vesicle glycoprotein 2 (SV2). Whether and how PSGs and S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bce58369df1764dd9ade86c6d436254
https://hdl.handle.net/20.500.11820/ba1259b2-1e41-40ca-b588-79326111cfdd
https://hdl.handle.net/20.500.11820/ba1259b2-1e41-40ca-b588-79326111cfdd
Autor:
Merja Joensuu, Vanessa Lanoue, Parnayan Syed, Tristan P. Wallis, James Rae, Ailisa Blum, Rachel Gormal, Christopher Small, Shanley Sanders, Anmin Jiang, Stefan Mahrhold, Nadja Krez, Michael Cousin, Ruby Cooper-White, Justin J. Cooper-White, Brett M. Collins, Robert G. Parton, Giuseppe Balistreri, Andreas Rummel, Frédéric A. Meunier
The extreme neurotoxicity of botulinum neurotoxins (BoNTs), broadly used as a therapeutics, is mediated by their direct binding to two plasma membrane receptors: polysialogangliosides (PSGs) and serotype-dependently either synaptotagmin 1/2 (Syt1/2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b8a1b334c23e1f2878ae367fcf15319
https://doi.org/10.1101/2022.02.28.482398
https://doi.org/10.1101/2022.02.28.482398
Autor:
Maria B. Nowakowska, Katja Selby, Adina Przykopanski, Maren Krüger, Nadja Krez, Brigitte G. Dorner, Martin B. Dorner, Rongsheng Jin, Nigel P. Minton, Andreas Rummel, Miia Lindström
Publikováno v:
Scientific Reports
Scientific reports, vol 12, iss 1
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Scientific reports, vol 12, iss 1
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Never
Autor:
Mark E. Bowen, Tsutomu Matsui, Jasmin Weisemann, Andreas Rummel, Rongsheng Jin, Kwok-Ho Lam, Kay Perry, Zhuojun Guo, Nadja Krez
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Lam, Kwok-Ho; Guo, Zhuojun; Krez, Nadja; Matsui, Tsutomu; Perry, Kay; Weisemann, Jasmin; et al.(2018). A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.. Nature communications, 9(1), 5367. doi: 10.1038/s41467-018-07789-4. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/99m85024
Nature Communications
Lam, Kwok-Ho; Guo, Zhuojun; Krez, Nadja; Matsui, Tsutomu; Perry, Kay; Weisemann, Jasmin; et al.(2018). A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1.. Nature communications, 9(1), 5367. doi: 10.1038/s41467-018-07789-4. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/99m85024
Nature Communications
Botulinum neurotoxin (BoNT) delivers its protease domain across the vesicle membrane to enter the neuronal cytosol upon vesicle acidification. This process is mediated by its translocation domain (HN), but the molecular mechanism underlying membrane