Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Nadja Karl"'
Autor:
Mohammed Samer Shaban, Christin Müller, Christin Mayr-Buro, Hendrik Weiser, Johanna Meier-Soelch, Benadict Vincent Albert, Axel Weber, Uwe Linne, Torsten Hain, Ilya Babayev, Nadja Karl, Nina Hofmann, Stephan Becker, Susanne Herold, M. Lienhard Schmitz, John Ziebuhr, Michael Kracht
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Here, Shaban et al. show that coronaviruses modulate ER stress and the unfolded protein response. The ER stress inducer thapsigargin exerts potent antiviral effects, partially reverses the virus-induced translational shut-down, reprograms the host pr
Externí odkaz:
https://doaj.org/article/a6f9af13b42d437eab2e9eaf4c3fe912
Autor:
Michael Poppe, Sascha Wittig, Liane Jurida, Marek Bartkuhn, Jochen Wilhelm, Helmut Müller, Knut Beuerlein, Nadja Karl, Sabin Bhuju, John Ziebuhr, M Lienhard Schmitz, Michael Kracht
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006286 (2017)
Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nuc
Externí odkaz:
https://doaj.org/article/5360acc7ff904d7fbc39af9d12d4e187
Autor:
Eveline Kindler, Cristina Gil-Cruz, Julia Spanier, Yize Li, Jochen Wilhelm, Huib H Rabouw, Roland Züst, Mihyun Hwang, Philip V'kovski, Hanspeter Stalder, Sabrina Marti, Matthias Habjan, Luisa Cervantes-Barragan, Ruth Elliot, Nadja Karl, Christina Gaughan, Frank J M van Kuppeveld, Robert H Silverman, Markus Keller, Burkhard Ludewig, Cornelia C Bergmann, John Ziebuhr, Susan R Weiss, Ulrich Kalinke, Volker Thiel
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006195 (2017)
Coronaviruses are of veterinary and medical importance and include highly pathogenic zoonotic viruses, such as SARS-CoV and MERS-CoV. They are known to efficiently evade early innate immune responses, manifesting in almost negligible expression of ty
Externí odkaz:
https://doaj.org/article/2a3c2f89056640d2ba120a052b6db146
Autor:
Heiko Slanina, Ramakanth Madhugiri, Kai Wenk, Tess Reinke, Karin Schultheiß, Julia Schultheis, Nadja Karl, Uwe Linne, John Ziebuhr
Publikováno v:
Journal of Virology.
There is strong evidence that coronaviruses and other large nidoviruses evolved a number of unique enzymatic activities, including an additional RdRp-associated NiRAN domain, that are conserved in nidoviruses but not in most other RNA viruses. Previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8622f48fbbe5f39fe653d22ec024894
https://doi.org/10.1128/jvi.00465-23
https://doi.org/10.1128/jvi.00465-23
Autor:
Ilya Babayev, Susanne Herold, M. Lienhard Schmitz, Stephan Becker, Nadja Karl, Christin Müller, Uwe Linne, Benadict Vincent Albert, Michael Kracht, Axel Weber, Mohammed Samer Shaban, Nina Hofmann, John Ziebuhr, Torsten Hain, Christin Mayr-Buro, Hendrik Weiser
Coronaviruses (CoVs) are important human pathogens for which no specific treatment is available. Here, we provide evidence that pharmacological reprogramming of ER stress pathways can be exploited to suppress CoV replication. We found that the ER str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7834504f51a2417b7fef99dba876cc3c
https://doi.org/10.1101/2020.08.26.266304
https://doi.org/10.1101/2020.08.26.266304
Publikováno v:
Journal of General Virology. 99:1253-1260
White bream virus (WBV), a poorly characterized plus-strand RNA virus infecting freshwater fish of the Cyprinidae family, is the prototype species of the genus Bafinivirus in the subfamily Torovirinae (family Coronaviridae, order Nidovirales). In com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7dd8af4f7b5d84ee36fa2b30bd800cd
https://doi.org/10.1099/jgv.0.001120
https://doi.org/10.1099/jgv.0.001120
Autor:
Markus Fricke, Nadja Karl, Manja Marz, Kevin Lamkiewicz, Daniel Petersen, John Ziebuhr, Ramakanth Madhugiri, Ulrike C. Wend, Robina Scheuer
Publikováno v:
Virology
Structure predictions suggest a partial conservation of RNA structure elements in coronavirus terminal genome regions. Here, we determined the structures of stem-loops (SL) 1 and 2 of two alphacoronaviruses, human coronavirus (HCoV) 229E and NL63, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abb427839c2a463767634cd999975c3
https://doi.org/10.1016/j.virol.2017.11.025
https://doi.org/10.1016/j.virol.2017.11.025
Autor:
Ganesh Bylapudi, John Ziebuhr, Nadja Karl, Ramakanth Madhugiri, Lyndsey J. Ferguson, Jana Tvarogová
Publikováno v:
Journal of Virology
Coronavirus nonstructural protein 8 (nsp8) has been suggested to have diverse activities, including noncanonical template-dependent polymerase activities. Here, we characterized a recombinant form of the human coronavirus 229E (HCoV-229E) nsp8 and fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a48ab672e46cb4d9c90805d00b9d008
Autor:
Marek Bartkuhn, Michael Kracht, Sabin Bhuju, Nadja Karl, Knut Beuerlein, John Ziebuhr, Michael Poppe, Helmut Müller, Liane Jurida, M. Lienhard Schmitz, Sascha Wittig, Jochen Wilhelm
Publikováno v:
PLoS Pathogens, Vol 13, Iss 3, p e1006286 (2017)
PLOS Pathogens
PLoS Pathogens
PLOS Pathogens
PLoS Pathogens
Coronavirus replication takes place in the host cell cytoplasm and triggers inflammatory gene expression by poorly characterized mechanisms. To obtain more insight into the signals and molecular events that coordinate global host responses in the nuc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b9e241c3a888a88fd684c8bddaca1d
https://doaj.org/article/5360acc7ff904d7fbc39af9d12d4e187
https://doaj.org/article/5360acc7ff904d7fbc39af9d12d4e187
Autor:
Nadja Karl, Hanspeter Stalder, Mihyun Hwang, Luisa Cervantes-Barragan, Yize Li, Volker Thiel, Sabrina Marti, Philip V'kovski, Julia Spanier, Christina Gaughan, Markus Keller, Susan R. Weiss, Cornelia C. Bergmann, Robert H. Silverman, Cristina Gil-Cruz, Jochen Wilhelm, Matthias Habjan, Ulrich Kalinke, Frank J. M. van Kuppeveld, Burkhard Ludewig, Roland Züst, Huib H. Rabouw, Eveline Kindler, Ruth Elliot, John Ziebuhr
Publikováno v:
PLOS Pathogens
Kindler, Eveline Patricia; Gil-Cruz, Cristina; Spanier, Julia; Li, Yize; Wilhelm, Jochen; Rabouw, Huib H; Züst, Roland; Hwang, Mihyun; V'Kovski, Philip; Stalder, Hanspeter; Marti, Sabrina; Habjan, Matthias; Cervantes-Barragan, Luisa; Elliot, Ruth; Karl, Nadja; Gaughan, Christina; van Kuppeveld, Frank J M; Silverman, Robert H; Keller, Markus; Ludewig, Burkhard; ... (2017). Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS pathogens, 13(2), e1006195. Public Library of Science 10.1371/journal.ppat.1006195
PLoS Pathogens, 13(2). Public Library of Science
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006195 (2017)
Kindler, Eveline Patricia; Gil-Cruz, Cristina; Spanier, Julia; Li, Yize; Wilhelm, Jochen; Rabouw, Huib H; Züst, Roland; Hwang, Mihyun; V'Kovski, Philip; Stalder, Hanspeter; Marti, Sabrina; Habjan, Matthias; Cervantes-Barragan, Luisa; Elliot, Ruth; Karl, Nadja; Gaughan, Christina; van Kuppeveld, Frank J M; Silverman, Robert H; Keller, Markus; Ludewig, Burkhard; ... (2017). Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication. PLoS pathogens, 13(2), e1006195. Public Library of Science 10.1371/journal.ppat.1006195
PLoS Pathogens, 13(2). Public Library of Science
PLoS Pathogens
PLoS Pathogens, Vol 13, Iss 2, p e1006195 (2017)
Coronaviruses are of veterinary and medical importance and include highly pathogenic zoonotic viruses, such as SARS-CoV and MERS-CoV. They are known to efficiently evade early innate immune responses, manifesting in almost negligible expression of ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5362c6e7567d79f689524cac2db3bcc2