Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Nadja I Lorenz"'
Autor:
Benedikt Sauer, Nadja I. Lorenz, Iris Divé, Kevin Klann, Anna-Luisa Luger, Hans Urban, Jan-Hendrik Schröder, Joachim P. Steinbach, Christian Münch, Michael W. Ronellenfitsch
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-10 (2024)
Abstract Glioblastoma is an incurable brain tumor with a median survival below two years. Trials investigating targeted therapy with inhibitors of the kinase mTOR have produced ambiguous results. Especially combination of mTOR inhibition with standar
Externí odkaz:
https://doaj.org/article/9ab4a9c77f214ad88451e3c0fada1f73
Autor:
Catherine Delbrouck, Nicole Kiweler, Oleg Chen, Vitaly I. Pozdeev, Lara Haase, Laura Neises, Anaïs Oudin, Aymeric Fouquier d’Hérouël, Ruolin Shen, Lisa Schlicker, Rashi Halder, Antoine Lesur, Anne Schuster, Nadja I. Lorenz, Christian Jaeger, Maureen Feucherolles, Gilles Frache, Martyna Szpakowska, Andy Chevigne, Michael W. Ronellenfitsch, Etienne Moussay, Marie Piraud, Alexander Skupin, Almut Schulze, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113034- (2023)
Summary: Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we
Externí odkaz:
https://doaj.org/article/d667e6854d774c98bcdedc3d5a151980
Autor:
Nadja I. Lorenz, Alina C. M. Sittig, Hans Urban, Anna-Luisa Luger, Anna L. Engel, Christian Münch, Joachim P. Steinbach, Michael W. Ronellenfitsch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4). W
Externí odkaz:
https://doaj.org/article/0736b208a57543ffb304b79c8033e560
Autor:
Dennis Heinzen, Iris Divé, Nadja I. Lorenz, Anna-Luisa Luger, Joachim P. Steinbach, Michael W. Ronellenfitsch
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 18, p 4474 (2019)
Glioblastomas (GBs) frequently display activation of the epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR). mTOR exists as part of two multiprotein complexes, mTOR complex 1 (mTORC1) and 2 (mTORC2). In GBs, mTORC1 inhib
Externí odkaz:
https://doaj.org/article/dad3e049e1194fbe8e9c21d31380f674
Autor:
Nadja I. Lorenz, Benedikt Sauer, Pia S. Zeiner, Maja I. Strecker, Anna-Luisa Luger, Dorothea Schulte, Michel Mittelbronn, Tijna Alekseeva, Lisa Sevenich, Patrick N. Harter, Christian Münch, Joachim P. Steinbach, Michael W. Ronellenfitsch
AMP-activated protein kinase (AMPK) is a central cellular energy sensor that regulates metabolic activity. We hypothesised that in glioblastoma (GB), AMPK plays a pivotal role in balancing metabolism under conditions of the tumour microenvironment, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::193b92bc1d62a935813004ce499f29aa
https://doi.org/10.1101/2022.03.25.485624
https://doi.org/10.1101/2022.03.25.485624
Autor:
Kevin Klann, Christian Münch, Joachim P. Steinbach, Anna L Engel, Cornelia Depner, Nadja I Lorenz, Michael W. Ronellenfitsch, Anna-Luisa Luger
Publikováno v:
British Journal of Cancer
BackgroundThe amino acid serine is an important substrate for biosynthesis and redox homeostasis. We investigated whether glioblastoma (GBM) cells are dependent on serine for survival under conditions of the tumour microenvironment.MethodsSerine avai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937d2713c5f8778884bbbc4a622bb1aa
https://doi.org/10.1038/s41416-020-0794-x
https://doi.org/10.1038/s41416-020-0794-x
Autor:
Benedikt Sauer, Nadja I. Lorenz, Christian Munch, Joachim P. Steinbach, Michael W. Ronellenfitsch
Publikováno v:
WFNOS 2022 Abstract Book.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4898024bf9e4a602600aa6aed896e584
https://doi.org/10.14791/btrt.2022.10.f-1288
https://doi.org/10.14791/btrt.2022.10.f-1288
Autor:
Martin Voss, Nadja I. Lorenz, Anna-Luisa Luger, Joachim P. Steinbach, Johannes Rieger, Michael W. Ronellenfitsch
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2462 (2018)
Cancer metabolism is characterized by extensive glucose consumption through aerobic glycolysis. No effective therapy exploiting this cancer trait has emerged so far, in part, due to the substantial side effects of the investigated drugs. In this stud
Externí odkaz:
https://doaj.org/article/c57636def0e84cf7b4e6958d9d6b89b3
Autor:
Benedikt Sauer, Anna-Luisa Luger, M. Foltyn, Nadja I Lorenz, Patrick N. Harter, Joachim P. Steinbach, Michael W. Ronellenfitsch, Michel Mittelbronn
Publikováno v:
British Journal of Cancer
Background Despite significant advances in the understanding of glioblastoma genetics and biology, survival is still poor. Hypoxia and nutrient depletion in the tumour microenvironment induce adaptive signalling and metabolic responses, which can inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50be968c5cdca53b1cd35319eb4dca4c
https://doi.org/10.1038/s41416-018-0368-3
https://doi.org/10.1038/s41416-018-0368-3
Autor:
Gabriele D. Maurer, Benedikt Sauer, Jörg Trojan, Joachim P. Steinbach, Anna-Luisa Luger, Nadja I Lorenz, Patrick N. Harter, Hans Urban, Michael W. Ronellenfitsch, Michel Mittelbronn, C. Stroh
Publikováno v:
Cancers, Vol 12, Iss 3050, p 3050 (2020)
Cancers
Volume 12
Issue 10
Cancers
Volume 12
Issue 10
Monoclonal antibodies like cetuximab, targeting the epidermal growth factor receptor (EGFR), and bevacizumab, targeting the vascular endothelial growth factor (VEGF), are an integral part of treatment regimens for metastasized colorectal cancer. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6e1cb84dcbaa5d3515a2639346712c
https://www.mdpi.com/2072-6694/12/10/3050
https://www.mdpi.com/2072-6694/12/10/3050