A mouse model for ulcerative colitis based on NOD-scid IL2R γnull mice reconstituted with peripheral blood mononuclear cells from affected individuals

Autor: Pia Palamides, Henrika Jodeleit, Michael Föhlinger, Florian Beigel, Nadja Herbach, Thomas Mueller, Eckhard Wolf, Matthias Siebeck, Roswitha Gropp

Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 9, Pp 985-997 (2016)

Animal models reflective of ulcerative colitis (UC) remain a major challenge, and yet are crucial to understand mechanisms underlying the onset of disease and inflammatory characteristics of relapses and remission. Mouse models in which colitis-like

Externí odkaz: https://doaj.org/article/8ffac03335954a1cbd880b3be77d2f5a

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs.

Autor: Andrea Bähr, Tobias Käser, Elisabeth Kemter, Wilhelm Gerner, Mayuko Kurome, Wiebke Baars, Nadja Herbach, Kirsti Witter, Annegret Wünsch, Stephanie C Talker, Barbara Kessler, Hiroshi Nagashima, Armin Saalmüller, Reinhard Schwinzer, Eckhard Wolf, Nikolai Klymiuk

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0155676 (2016)

We have successfully established and characterized a genetically modified pig line with ubiquitous expression of LEA29Y, a human CTLA4-Ig derivate. LEA29Y binds human B7.1/CD80 and B7.2/CD86 with high affinity and is thus a potent inhibitor of T cell

Externí odkaz: https://doaj.org/article/e75f73ab30a64d0e96c7cf098e868895

Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice.

Autor: Nadja Herbach, Martina Bergmayr, Burkhard Göke, Eckhard Wolf, Ruediger Wanke

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22814 (2011)

The aim of this study was to examine postnatal islet and beta-cell expansion in healthy female control mice and its disturbances in diabetic GIPR(dn) transgenic mice, which exhibit an early reduction of beta-cell mass. Pancreata of female control and

Externí odkaz: https://doaj.org/article/38f7dd2c5675474aa524d8415c428459

Targeting mTOR Signaling Can Prevent the Progression of FSGS

Autor: Fabiola Terzi, Simon D. Gerber, Tobias B. Huber, Oliver Kretz, Amandine Viau, Changli Wei, Wei Liang, Nadja Herbach, Gerd Walz, Clemens D. Cohen, Matias Simons, Stefan Munder, Tillmann Bork, Björn Hartleben, Markus Gödel, Kristina Eulenbruch, Maria Pia Rastaldi, Jochen Reiser, Pierre-Louis Tharaux, Martine Burtin, Nicola Wanner, Stefan Zschiedrich

Publikováno v: Journal of the American Society of Nephrology
Journal of the American Society of Nephrology, American Society of Nephrology, 2017, 28 (7), pp.2144-2157. ⟨10.1681/asn.2016050519⟩

International audience; Mammalian target of rapamycin (mTOR) signaling is involved in a variety of kidney diseases. Clinical trials administering mTOR inhibitors to patients with FSGS, a prototypic podocyte disease, led to conflicting results, rangin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733bcebba87b36d94a0b6111f91ee96e
https://doi.org/10.1681/asn.2016050519

Solid Aneurysmal Bone Cyst of the Distal Metatarsus in a Horse

Autor: Nadja Herbach, Peter Lambrecht, Christina Terboven

Publikováno v: Open Journal of Pathology. :88-92

A horse was presented with a slowly growing mass of the distal metatarsal region of the right hind leg. Radiographic examination revealed an eccentric cyst-like lesion with distortion of the lateral margin of the distal metatarsus. The lesion involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::26f3242305c123cac2a969ff5e4d41a9
https://doi.org/10.4236/ojpathology.2016.62011