Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Nadja Engel"'
Autor:
Thomas Freitag, Philipp Kaps, Justus Ramtke, Sarah Bertels, Emily Zunke, Björn Schneider, Anne-Sophie Becker, Dirk Koczan, Daniel Dubinski, Thomas M. Freiman, Felix Wittig, Burkhard Hinz, Mike-Andrew Westhoff, Hannah Strobel, Franziska Meiners, Daniel Wolter, Nadja Engel, Sascha Troschke-Meurer, Wendy Bergmann-Ewert, Susanne Staehlke, Annabell Wolff, Florian Gessler, Christian Junghanss, Claudia Maletzki
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-17 (2024)
Abstract Here, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual blockade led to HIF1α upregulation and CalR translocation, accomp
Externí odkaz:
https://doaj.org/article/48c31a82a0d54c5ea79c6f99d70e3d61
Autor:
Said Kdimati, Clemens Christoph, Änne Glass, Nadja Engel, Desiree-Louise Dräger, Claudia Maletzki, Anne-Sophie Becker, Annette Zimpfer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3492 (2024)
Upper tract urothelial carcinoma (UTUC) accounts for 5–10% of all UCs. Immune checkpoint inhibitors (ICIs) have been established for UCs. The prognostic and predictive potential of programmed cell death ligand 1 (PD-L1) expression to stratify patie
Externí odkaz:
https://doaj.org/article/d779168de4b94a03a011ac95611f7b60
Autor:
Christin Riess, Katharina del Moral, Adina Fiebig, Philipp Kaps, Charlotte Linke, Burkhard Hinz, Anne Rupprecht, Marcus Frank, Tomas Fiedler, Dirk Koczan, Sascha Troschke-Meurer, Holger N. Lode, Nadja Engel, Thomas Freitag, Carl Friedrich Classen, Claudia Maletzki
Publikováno v:
Cell Death and Disease, Vol 13, Iss 6, Pp 1-14 (2022)
The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole fo
Externí odkaz:
https://doaj.org/article/e4a237d57e9d4704bd9c0f69a431ba27
Autor:
Denise Franz, Marco Heerdegen, Nadja Engel, Fabiana Santana Kragelund, Anika Lüttig, Stefanie Perl, Angelika Richter, Rüdiger Köhling
Publikováno v:
Brain Stimulation, Vol 16, Iss 1, Pp 265- (2023)
Externí odkaz:
https://doaj.org/article/5a761feea3664d4f9dc86d671b221bcf
Autor:
Akachukwu Ibezim, Mbanefo S. Madukaife, Sochi C. Osigwe, Nadja Engel, Ramanathan Karuppasamy, Fidele Ntie-Kang
Publikováno v:
BMC Chemistry, Vol 16, Iss 1, Pp 1-9 (2022)
Abstract Type III beta phosphatidylinositol 4-kinase (PI4KIIIβ) is the only clinically validated drug target in Plasmodium kinases and therefore a critical target in developing novel drugs for malaria. Current PI4KIIIβ inhibitors have solubility an
Externí odkaz:
https://doaj.org/article/6a6ea292690840adaf99867b801cc5f7
Autor:
Nadja Engel, Carsten Fechner, Annika Voges, Robert Ott, Jan Stenzel, Stefan Siewert, Carina Bergner, Valeria Khaimov, Jan Liese, Klaus-Peter Schmitz, Bernd Joachim Krause, Bernhard Frerich
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract A clinical implementation of cell-based bone regeneration in combination with scaffold materials requires the development of efficient, controlled and reproducible seeding procedures and a tailor-made bioreactor design. A perfusion system fo
Externí odkaz:
https://doaj.org/article/035a8910773f4f7a95dcd461eca70e5a
Autor:
Anna Adamus, Iftikhar Ali, Vasileios Vasileiadis, Luai Al-Hileh, Jan Lisec, Marcus Frank, Guido Seitz, Nadja Engel
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Prevention of metastatic invasion is one of the main challenges in the treatment of alveolar rhabdomyosarcoma. Still the therapeutic options are limited. Therefore, an anti-tumor screening was initiated focusing on the anti-metast
Externí odkaz:
https://doaj.org/article/708a18ee1ade4a02bd1a3d8d8da49da2
Autor:
Nadja Engel, Michael Dau, Vivien Engel, Denise Franz, Fabian Klemmstein, Christiane Thanisch, Jürgen F. Kolb, Marcus Frank, Armin Springer, Rüdiger Köhling, Rainer Bader, Bernhard Frerich, Nadine Wiesmann, Diana Heimes, Peer W. Kämmerer
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 697 (2023)
(1) Background: Electrical stimulation is a promising alternative to promote bone fracture healing but with the limitation of tracking the osteogenesis progress in vivo. To overcome this issue, we present an opportunity to combine the electrical stim
Externí odkaz:
https://doaj.org/article/7c065665739244de8314beaeec9664d1
Autor:
Janine Waletzko-Hellwig, Christopher Pohl, Janik Riese, Michael Schlosser, Michael Dau, Nadja Engel, Armin Springer, Rainer Bader
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
The reconstruction of critical size bone defects is still clinically challenging. Even though the transplantation of autologous bone is used as gold standard, this therapy is accompanied by donor site morbidities as well as tissue limitations. The al
Externí odkaz:
https://doaj.org/article/bdf082650f924e20a205535776c050d9
Publikováno v:
Journal of Cancer Research and Practice, Vol 5, Iss 2, Pp 53-66 (2018)
Annona muricata has been attributed with numerous health benefits – including anticancer properties. The aim of this study was to carry out anticancer investigations of fractions of Annona muricata, by isolating a key compound and assessing antioxi
Externí odkaz:
https://doaj.org/article/29f82e9d0d8545a29909af698ed8ce12