Výsledky vyhledávání - "Nadja Dunger"

Galectin-3 Modulates Experimental Colitis

Autor: Claudia Kunst, Manuela Stieber-Gunckel, Florian Obermeier, Werner Falk, Elisabeth Lippert, Nadja Dunger

Publikováno v: Digestion. 92:45-53

Background: We recently identified galectin-3 (gal-3) as a new and strong fibroblast activator produced by colonic epithelial cells. Very little is known about the influence of gal-3 in inflammatory bowel disease. We, therefore, investigated the impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2597ef26fe2b08839cb3a0f8124d5aef
https://doi.org/10.1159/000431312

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Anthocyanins Prevent Colorectal Cancer Development in a Mouse Model

Autor: Gerhard Rogler, Petra Ruemmele, Nadja Dunger, Claudia Kunst, Arndt Hartmann, Helmut Messmann, Esther Endlicher, Stefan Goelder, Elisabeth Lippert, Florian Obermeier

Background: Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5679d56b8bb72da11b722aacf9c9ad8c
https://opus4.kobv.de/opus4-fau/files/10795/DIG475524.pdf

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Physiologic TLR9-CpG-DNA Interaction Is Essential for the Homeostasis of the Intestinal Immune System

Autor: Matthias Edinger, Claudia Hofmann, Elisabeth Lippert, Kristina Doser, Werner Falk, Florian Obermeier, Nadja Dunger, Sebastian Siller

Publikováno v: Inflammatory Bowel Diseases. 20:136-143

Background Cytosine-guanosine dinucleotide (CpG) motifs are immunostimulatory components of bacterial DNA and activators of innate immunity through Toll-like receptor 9 (TLR9). Administration of CpG oligodeoxynucleotides before the onset of experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd41ecaf111272f3059fb128d0790dd
https://doi.org/10.1097/01.mib.0000436276.19755.c1

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T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells

Autor: Werner Falk, Florian Obermeier, Nicole Grunwald, Jürgen Schölmerich, Nadja Dunger, Claudia Hofmann, Günter J Hämmerling, Petra Hoffmann

Publikováno v: Gut. 59:1347-1354

Background Oligodeoxynucleotides (ODNs) containing unmethylated cytosine–guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the ons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6e19a4c6a73aa40b4531d95198fcd9
https://doi.org/10.1136/gut.2009.193177

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In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis

Autor: D. H. Paper, Juergen Schoelmerich, Florian Obermeier, Nadja Dunger, K. Menzel, Werner Falk, Gerhard Rogler, Martin Hausmann, K. Balan, Hans H Herfarth

Publikováno v: Clinical and Experimental Immunology. 148:373-381

Summary Recently we demonstrated that in inflammatory bowel disease (IBD) macrophage-oxidative burst activity is increased and NADPH oxidase mRNA is induced. The herbal phenylethanoid acteoside isolated from Plantago lanceolata L. was shown to exhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1536db96dc34e913a19a3208ce57fc0
https://doi.org/10.1111/j.1365-2249.2007.03350.x

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Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo

Autor: K. Schreiter, J. Schölmerich, Nadja Dunger, Martin Hausmann, Hans H Herfarth, Gerhard Rogler, Frauke Bataille, Florian Obermeier, Werner Falk, K. Menzel

Publikováno v: Clinical and Experimental Immunology. 146:169-180

Summary The cathepsins D (CTSD), B (CTSB) and L (CTSL) are important for the intracellular degradation of proteins. Increased cathepsin expression is associated with inflammatory diseases. We have shown previously an induction of CTSD expression in i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a8be9c3c0b12ce27685de9430f61452
https://doi.org/10.1111/j.1365-2249.2006.03188.x

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Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitis

Autor: Heiko C. Rath, Nicole Grunwald, D P Griese, Ulrike Strauch, J. Schölmerich, Michael Schultz, Nadja Dunger, S Gürster, M Mähler, Florian Obermeier

Publikováno v: Gut. 54:1546-1552

Background: The resident flora plays a critical role in initiation and perpetuation of intestinal inflammation, as demonstrated in experimental models of colitis where animals fail to develop disease under germ free conditions. However, the importanc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14aba163f82d306e83d209a02bed08a
https://doi.org/10.1136/gut.2004.059451

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CpG Motifs of Bacterial DNA Essentially Contribute to the Perpetuation of Chronic Intestinal Inflammation

Autor: Claudia Hofmann, Nicole Grunwald, Brigitte Schlegelberger, Hans J. Hedrich, Jürgen Schölmerich, Nadja Dunger, Werner Falk, André Bleich, E. Aschenbrenner, Ulrike Strauch, Florian Obermeier, Gerhard Rogler

Publikováno v: Gastroenterology. 129:913-927

Background & Aims: Recently, we demonstrated a proinflammatory effect of cytosin-guanosin dinucleotide (CpG)-oligodeoxynucleotide (ODN) treatment in established dextran sulphate sodium (DSS)-induced colitis. Here, we investigated whether DNA derived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd3b7744d885d7c76e6ea3c4bf7a3f0
https://doi.org/10.1053/j.gastro.2005.06.061

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